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Mashup Score: 21The enchanting canvas of CAR technology: Unveiling its wonders in non-neoplastic diseases - 11 hour(s) ago
Shu et al. summarize the diverse applications of chimeric antigen receptor (CAR)-based cellular platforms beyond cancer, focusing on autoimmune, infectious, fibrotic, and senescence-related diseases. In addition, they offer insights into CAR applications in non-T cell populations such as NK cells and macrophages, underscoring their potential for personalized therapies.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 9Targeting METTL3 reprograms the tumor microenvironment to improve cancer immunotherapy - 12 hour(s) ago
Yu et al. report inhibiting METTL3 reprograms an inflamed tumor microenvironment that renders anti-PD-1 therapy more effective in several preclinical mouse NSCLC tumor models, highlighting the combination of METTL3 inhibitor with PD-1/PD-L1 immune-checkpoint blockade as a promising therapeutic strategy for NSCLC patients.
Source: www.cell.comCategories: General Medicine News, General NewsTweet
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Mashup Score: 28Dopamine-sensitive neurons in the mesencephalic locomotor region control locomotion initiation, stop, and turns - 12 hour(s) ago
Juárez Tello et al. show that dopamine-sensitive neurons in the mesencephalic locomotor region control movement. D1 receptor-positive neurons in the cuneiform and pedunculopontine nuclei promote locomotion. D2 receptor-positive neurons in the cuneiform nucleus stop locomotion, while D2 receptor-positive neurons in the pedunculopontine nucleus induce ipsilateral turning.
Source: www.cell.comCategories: General Medicine News, General Journals & SocietTweet
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Mashup Score: 48Astroglial gap junctions strengthen hippocampal network activity by sustaining afterhyperpolarization via KCNQ channels - 14 hour(s) ago
Dossi et al. investigate the mechanisms underlying neuronal network activity modulation by gap-junction-mediated astroglial networks. Combining modeling and experimental approaches, they show that astroglial networks strengthen hippocampal bursting patterns by sustaining neuronal afterhyperpolarization via extracellular potassium modulation of KCNQ potassium channels. This pathway controls in vivo physiological oscillatory activity.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 156
Cancer-associated fibroblasts (CAFs) exhibit spatial and functional diversity. Here, Niu et al. unveil SETD2’s function in lipid metabolism and CAF heterogeneity in pancreatic ductal adenocarcinoma. SETD2 deficiency boosts oxidative phosphorylation activity, prompting lipid-laden CAF formation through BMP2 signaling, offering promising therapeutic avenues in personalized cancer treatment.
Source: www.cell.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 212
Tumor-associated macrophages (TAMs) are well known to fuel tumor evolution. Blériot et al. advocate for integrating the time dimension when conceptualizing macrophage diversity in pre-malignancy and cancer and propose the term “PreTAMs” to emphasize their early roles in orchestrating inflammatory responses that often precede, and not just result from, tumor onset.
Source: www.cell.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 10Five decades of genetics and genomics - 16 hour(s) ago
Some of the most significant discoveries in the life sciences over the last 50 years stem from genetics and genomics. This field has also seen large-scale collaborative efforts yield fundamental milestones and results, such as the Human Genome Project. Despite a long road ahead, progress in both basic and clinical genetics now drives sweeping efforts to cure complex human ailments such as blood and psychiatric disorders, metabolic diseases, cancer, and neurodegeneration. While these large tent-pole endeavors receive the most attention, cutting-edge modern genetics techniques are foundational to the science that happens daily across the biomedical life sciences.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 118Circadian tumor infiltration and function of CD8+ T cells dictate immunotherapy efficacy - 1 day(s) ago
Efficacy of CAR T cell therapy and immune checkpoint blockade in cancer can be improved by adjusting the time of treatment during the day due to rhythmic infiltration and function of T cells regulated by the circadian clock in T cells and endothelial cells in the tumor microenvironment.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 18Parvalbumin interneuron activity in autism underlies susceptibility to PTSD-like memory formation - 1 day(s) ago
Behavioral neuroscience; Molecular neuroscience; Cellular neuroscience
Source: www.cell.comCategories: General Medicine News, NeurologyTweet
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Mashup Score: 6
Blue et al. characterize the genetic basis of isolated hypoplastic left heart syndrome (iHLHS), implicating hypomorphic CAPN2 variants through association testing and functional validation in a Xenopus laevis model. Their results suggest that iHLHS is not typically a Mendelian condition and identify a novel pathway involved in HLHS pathogenesis.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
Online now in @MedCellPress! The enchanting canvas of CAR technology: Unveiling its wonders in non-neoplastic diseases. Read the full reivew by researchers at Huazhong University of Science and Technology #ASGCT2024 https://t.co/QBp6f5CSnm