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Mashup Score: 2iPSC-derived hypoimmunogenic tissue resident memory T cells mediate robust anti-tumor activity against cervical cancer - 1 hour(s) ago
Furukawa and Ishii et al. demonstrate that induced pluripotent stem cell-derived HLA class I-edited human papilloma virus-specific cytotoxic T lymphocytes are not rejected by recipient CD8+ T cells and can evade attack by natural killer cells. These T cells enriched with tissue resident memory T cells exhibit robust cytotoxicity against cervical cancer, providing “off-the-shelf” T cell therapy.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 4
Rao and colleagues summarize the recent efforts to improve both efficiency and specificity of genome insertion technologies, highlight their capabilities and limitations, discuss their applications in biological research and translational medicine, and conclude with future directions to overcome existing bottlenecks.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 9
Jin et al. developed an in situ vaccination approach that combines radiation and intratumoral injection of a tumor-specific antibody and IL-2 (3xTx). This targeted 3xTx regimen elicits CD8+ T cell immunity supported by NK cell-mediated regulatory T cell antagonism in non-targeted tumors.
Source: www.cell.comCategories: General Medicine News, General NewsTweet
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Mashup Score: 2Metabolic priming of GD2 TRAC-CAR T cells during manufacturing promotes memory phenotypes while enhancing persistence - 3 hour(s) ago
Cappabianca and colleagues manufactured virus-free CAR T cells at scale with CRISPR-Cas9 and “metabolically primed” them by attenuating activation in low-glucose/glutamine medium with expansion in high-glucose/glutamine medium. Priming made CAR T cells with increased stem cell memory properties, including enriched central memory phenotypes in vivo while lysing solid tumors.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 2
Jackson and colleagues show that the introduction of ApoE2 using an AAV that transduces the ependymal cells of the ventricle causes a reduction in amyloid load and plaque associated synapse loss and reduces neuroinflammation by modulating microglial responsiveness to plaques.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 1
Human immunodeficiency virus (HIV)-1 infection is an important public health problem worldwide. After primary HIV-1 infection, transcribed HIV-1 DNA is integrated into the host genome, serving as a reservoir of the virus and hindering a definite cure. Although highly active antiretroviral therapy suppresses active viral replication, resulting in undetectable levels of HIV RNA in the blood, a viral rebound can be detected after a few weeks of treatment interruption. This supports the concept that there is a stable HIV-1 reservoir in people living with HIV-1.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 2A structure-function analysis shows SARS-CoV-2 BA.2.86 balances antibody escape and ACE2 affinity - 7 hour(s) ago
BA.2.86 spike has evolved extensively from the early Omicron variant BA.2, allowing it to escape the vast majority of anti-BA.2 monoclonal antibodies. While it is not quite as evasive as some other recent variants such as XBB.1.5, it has high affinity for the virus receptor ACE2 and is primed for further antigenic escape by mutation at residues 455 and/or 456 of the spike.
Source: www.cell.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 10
p53 plays a central role in suppressing tumorigenesis. In this issue, Liu et al. review the complexity of different layers of p53 regulation, and the recent advance of the p53 pathway in metabolism, ferroptosis, immunity, and others that largely expand the scope of its anti-tumor activity.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 11
Novel tissue-agnostic therapeutics targeting driver mutations in tumor cells have been recently approved by FDA, driven by basket trials that have demonstrated their efficacy and safety across diverse tumor histology. However, the relative rarity of primary brain tumors (PBTs) has limited their representation in early trials of tissue-agnostic medications. Thus, consensus continues to evolve regarding utility of tissue-agnostic medications in routine practice for PBTs, a diverse group of neoplasms characterized by limited treatment options and unfavorable prognoses. We describe current and potential impact of tissue-agnostic approvals on management of PBTs. We discuss data from clinical trials for PBTs regarding tissue-agnostic targets, including BRAFV600E, neurotrophic tyrosine receptor kinase (NTRK) fusions, microsatellite instability (MSI), mismatch repair deficiency (dMMR), and high tumor mutational burden (TMB-H), in context of challenges in managing PBTs. Described are additional
Source: www.cell.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 7Gastruloids generated without exogenous Wnt activation develop anterior neural tissues - 19 hour(s) ago
In this article, Lutolf and colleagues propose a new method to study post-implantation embryonic development in vitro. Aggregates of mouse embryonic stem cells were shown to differentiate into structures with embryo-like patterning and morphogenesis. Furthermore, initial aggregate size and inhibition of Wnt signaling has been shown to be crucial for the axial morphogenesis and emergence of anterior neural progenitors.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
iPSC-derived hypoimmunogenic tissue resident memory T cells mediate robust anti-tumor activity against cervical cancer - check out this study by researchers @juntendo_univ in @CellRepMed #ASGCT2024 https://t.co/3CVXr0Dq24