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Mashup Score: 5Targeting Cell Senescence and Senolytics: Novel Interventions for Age-Related Endocrine Dysfunction - 1 month(s) ago
Abstract. Multiple changes occur in hormonal regulation with aging and across various endocrine organs. These changes are associated with multiple age-related d
Source: academic.oup.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 0
Asthma is a heterogeneous chronic respiratory disease that impacts nearly 10% of the population worldwide. While cellular senescence is a normal physiological process, the accumulation of senescent cells is considered a trigger that transforms physiology into the pathophysiology of a tissue/organ. Recent advances have suggested the significance of cellular senescence in asthma. With this review, we focus on the literature regarding the physiology and pathophysiology of cellular senescence and cellular stress responses that link the triggers of asthma to cellular senescence, including telomere shortening, DNA damage, oncogene activation, oxidative-related senescence, and senescence-associated secretory phenotype (SASP).
Source: www.thelancet.comCategories: General Medicine Journals and Societies, Latest HeadlinesTweet
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Mashup Score: 6Biphasic JNK-Erk signaling separates the induction and maintenance of cell senescence after DNA damage induced by topoisomerase II inhibition - 9 month(s) ago
Genotoxic stress in mammalian cells, including those caused by anti-cancer chemotherapy, can induce temporary cell-cycle arrest, DNA damage-induced se…
Source: www.sciencedirect.comCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 0
Scientists link macrophages, or the first responders of the immune system, that have become so-called “zombie cells” in early-stage lung tumor growth.
Source: Discovery's EdgeCategories: General Medicine Journals and Societies, Latest HeadlinesTweet
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Mashup Score: 4
In this Review, the authors describe the relationships between persistent DNA damage, inflammation and cellular senescence, which represent a common pathway that contributes to the pathology of many conditions, including rheumatic diseases.
Source: NatureCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 2ICSA 2023 - 1 year(s) ago
Welcome We are pleased to announce the 8th International Cell Senescence Association (ICSA) Conference. The conference will be held October 24-27, 2023 at the Graduate Hotel in Minneapolis, Minnesota, hosted by the Institute on the Biology of Aging and Metabolism (iBAM) at the University of Minnesota and the Mayo Clinic Robert and Arlene Kogod Center…
Source: icsa2023minneapolis.comCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 8
Tumor cells triggered to senesce alter how they send and receive microenvironmental signals, leading to tissue remodeling, immune cell recruitment, hypersensitization to environmental IFNγ, and improved antitumor immunity.
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 3Hallmarks of aging: An expanding universe - 1 year(s) ago
Aging is a complex and multifactorial process. This reprise of the 2013 “The hallmarks of aging” reviews conceptual progress, additional hallmarks of aging, their interconnection, and preclinical anti-aging manipulations.
Source: CellCategories: Future of Medicine, Latest HeadlinesTweet
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Mashup Score: 3
Abstract. Cellular senescence is a stress response that activates innate immune cells, but little is known about its interplay with the adaptive immune system. Here, we show that senescent cells combine several features that render them highly efficient in activating dendritic cells (DCs) and antigen-specific CD8 T cells. This includes the release of alarmins, activation of interferon signaling,…
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0
Abstract. Cellular senescence involves a stable cell cycle arrest coupled to a secretory program that, in some instances, stimulates the immune clearance of senescent cells. Using an immune competent liver cancer model in which senescence triggers CD8 T cell-mediated tumor rejection, we show that senescence also remodels the cell surface proteome to alter how tumor cells sense environmental…
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet
Targeting Cell #Senescence and Senolytics: Novel Interventions for Age-Related Endocrine Regulation https://t.co/SMgnLEK8au