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    The purpose of this Challenge Competition is to solicit ideas on the future state of CDS Connect.

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    B cells are part of the adaptive immune system. After their first encounter with an antigen, B cells can differentiate into, memory B cells, plasmablasts (PB) and plasma cells (PC). They contribute to immunity through the production of antibodies, antigen presentation to T cells, production of proinflammatory cytokines, or anti-inflammatory cytokines that tune the immune response. B cells have been shown to have an important role in central nervous system (CNS disease). These cells can contribute to CNS diseases by peripheral actions or by their recruitment to the CNS. For immune cells to enter the CNS parenchyma, they must pass through CNS restrictive barriers of the post-capillary venules (blood-brain-barrier, meninges and choroid plexus). In healthy conditions, B cells are rarely found in the parenchyma, although they have a low presence in the perivascular space and are more frequent in the meninges, particularly in the dura mater and in the skull bone marrow. B cells can also be d

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