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    IntroductionBrain connectivity requires correct axonal guidance to drive axons to their appropriate targets. This process is orchestrated by guidance cues that exert attraction or repulsion to developing axons. However, the intricacies of the cellular machinery responsible for the correct response of growth cones are just being unveiled. Netrin-1 is a bifunctional molecule involved in axon pathfinding and cell migration that induces repulsion during postnatal cerebellar development. This process is mediated by UNC5 homolog receptors located on external granule layer (EGL) tracts.MethodsBiochemical, imaging and cell biology techniques, as well as syntaxin-1A/B (Stx1A/B) knock-out mice were used in primary cultures and brain explants.Results and discussionHere, we demonstrate that this response is characterized by enhanced membrane internalization through macropinocytosis, but not clathrin-mediated endocytosis. We show that UNC5A, UNC5B, and UNC5C receptors form a protein complex with th

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    • New Research: Syntaxin-1 is necessary for UNC5A-C/Netrin-1-dependent macropinocytosis and chemorepulsion: Introduction Brain connectivity requires correct axonal guidance to drive axons to their appropriate targets. This process… https://t.co/kfkDLrwmF4 #Molecular #Neuroscience

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    Epilepsy is a neurological disease that doubles or triples the risk of a person dying prematurely. Important causes of death among people with epilepsy include injuries, status epilepticus, and SUDEP, some of which may be preventable with access to high-quality specialty health care and compliance with effective treatment plans. In 2022, the Child Neurology Foundation convened a group of people with lived experience and experts in the epilepsy community from the US, Canada, and the UK to collaboratively

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    • Today is #SUDEP action day. Talking to #epilepsy patients about mortality risk factors can be difficult, but it's important. We worked with nearly 20 organizations to create a toolkit to help you initiate these conversations with your patients. https://t.co/Oq92wLC9Nr https://t.co/nue3HbxUKf

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    Neurology Today Editor-in-chief Joseph E. Safdieh, MD, FAAN, discusses new research on blood pressure targets for stroke after endovascular therapy, changing policies on CME, and a direct-to-consumer blood test for Alzheimer’s disease.

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    • In the latest episode of the #NeurologyToday in 5 podcast, Editor in Chief @BrainHealthMD chats about changing #CME policies, a direct-to-consumer blood test for #Alzheimers disease, and more from our new issue, out Thursday! https://t.co/hH4dlhfDP4 #NeuroTwitter @AANMember https://t.co/eNJSGqYIm8

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    JAMA Neurology is offering a 1-year editorial fellowship position that will provide a neurologist or doctorate-level clinician with hands-on training in editing and publishing a peer-reviewed medical journal.

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    • Apply for our 1-year Neurology Editorial Fellowship. Gain hands-on training and be fully prepared for an editorial role in a peer-reviewed journal. Application deadline: Dec 1. Learn more: https://t.co/LFQZ1fG3on https://t.co/z81QtK8R9S

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    The annual Society for Neuroscience (SfN) meeting yields significant, measurable impacts that conflict with the environmental commitment of the Society and the Intergovernmental Panel on Climate Change (IPCC) recommendations to address the climate emergency ([IPCC, 2018][1]). We used 12,761 presenters’ origins, two online carbon calculators, and benchmark values to estimate 2018 meeting-related travel, event venue operations, and hotel accommodation emissions. Presenters’ conference travel resulted in between 17,298 and 8690 tons of atmospheric carbon dioxide (t CO2), with or without radiative forcing index factors. Over 92% of authors traveled by air and were responsible for >99% of total travel-related emissions. Extrapolations based on 28,691 registrants yielded between 69,592.60 metric tons of carbon dioxide equivalents (t CO2e) and 38,010.85 t CO2 from travel. Comparatively, authors’ and registrants’ hotel accommodation emissions equaled 429 and 965 t CO2e, whereas operation of th

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    • #eNeuro | Recommendations Emerging from Carbon Emissions Estimations of the Society for Neuroscience Annual Meeting https://t.co/9s5aJPJLez

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    The EANpages editorial team’s selection of recently published papers of outstanding interest to neurologists for October 2023.

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    • #October Research Highlights feature three fascinating studies! ➡️Look into hearing interventions on #cognitivedecline, Extracranial-Intracranial Bypass in #stroke risk reduction & more! Click the link to learn! https://t.co/52vIrcjulB #EANhighlights #EANeurology https://t.co/9OGvgb5cJ5

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    ScienceDirect - 5 month(s) ago

    Read the latest articles of Physiology & Behavior at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature

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    • Call for Applications | Social Media Editor - Physiology & Behavior We are seeking a Social Media Editor who can leverage different forms of social media to disseminate information about PHB and increase our online presence. Learn more & apply: https://t.co/e4HgYwlRPu https://t.co/bzxDieT5Ef

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    Psychedelic indolethylamines have emerged as potential medicines to treat several psychiatric pathologies. Natural sources of these compounds include ‘magic mushrooms’ (Psilocybe spp.), plants used to prepare ayahuasca, and toads. The skin and parotid glands of certain toads accumulate a variety of specialized metabolites including toxic guanidine alkaloids, lipophilic alkaloids, poisonous steroids, and hallucinogenic indolethylamines such as DMT, 5-methoxy-DMT, and bufotenin. The occurrence of psychedelics has contributed to the ceremonial use of toads, particularly among Mesoamerican peoples.

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    • Chen et al. describe the discovery of a novel NMT, the first alkaloid biosynthetic enzyme isolated from toxin-rich toads. https://t.co/HL9vasvnhW