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Mashup Score: 12
Vol. 21 Issue 12 p3304 – 3316 Nicola J. Mutch Robert L. Medcalf Fibrinolysis is the system primarily responsible for removal of fibrin deposits and blood clots in the vasculature. The terminal enzyme in the pathway, plasmin, is formed from its circulating precursor, plasminogen. Fibrin is by far the most legendary substrate, but plasmin is notoriously prolific and is known to cleave many other proteins and participate in the activation of other proteolytic systems. Fibrinolysis is often overshadowed by
Source: www.jthjournal.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 11
On March 7, 2024, the Experimental Hematology community lost a legend. Editor of our journal (2017- June 2023), and a member of the International Society for Experimental Hematology (ISEH) for over 50 years, Professor Connie Eaves was thoroughly devoted to ISEH and its community of researchers. She contributed significantly to the ISEH leadership, notably as President (2002-2003) and was the highly deserving recipient of both the Donald Metcalf Award (2008) and the Outstanding Mentor award (2023).
Source: www.exphem.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 122023 Year in Review - 1 month(s) ago
The top downloaded, the top cited, and the Young Investigators articles published in Experimental Hematology (EXPHEM) in 2023
Source: www.elsevier.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 40ScienceDirect - 1 month(s) ago
Recent advances in metabolic assessments, genetic models and imaging techniques have led to rapidly accumulating new evidences regarding the metabolic requirements of hematopoietic homeostasis; however, it remains unclear how specific profiles of metabolism precisely control hematopoiesis. While snapshot single-cell RNA sequencing and lineage tracing models have helped unravel cell-to-cell variations and reconstruct developmental trajectories of hematopoietic stem cells (HSCs), the elucidation of individual bone marrow cell dynamics has been hindered by limits on our ability to isolate fully homogeneous cell populations and the high numbers of starting cells required by current transcriptomic platforms. A widely known model of hematopoiesis suggests that dormant HSCs are metabolically plastic and the activation of mitochondria to meet specific metabolic demands promotes HSC commitment. Recent studies have, however, demonstrated that inactivation of mitochondrial function impairs hemato
Source: www.sciencedirect.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 12
Vol. 21 Issue 12 p3304 – 3316 Nicola J. Mutch Robert L. Medcalf Fibrinolysis is the system primarily responsible for removal of fibrin deposits and blood clots in the vasculature. The terminal enzyme in the pathway, plasmin, is formed from its circulating precursor, plasminogen. Fibrin is by far the most legendary substrate, but plasmin is notoriously prolific and is known to cleave many other proteins and participate in the activation of other proteolytic systems. Fibrinolysis is often overshadowed by
Source: www.jthjournal.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 122023 Year in Review - 2 month(s) ago
The top downloaded, the top cited, and the Young Investigators articles published in Experimental Hematology (EXPHEM) in 2023
Source: www.elsevier.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 7The clinical, molecular, and prognostic features of the 2022 WHO and ICC classification systems for myelodysplastic neoplasms - 2 month(s) ago
Myelodysplastic neoplasms (MDS) are clonal disorders of bone marrow failure exhibiting a variable risk of progression to acute myeloid leukemia. MDS e…
Source: www.sciencedirect.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 6A comparative in vitro study of the anticoagulant effect of branded versus generic rivaroxaban - 2 month(s) ago
Several generic formulations of rivaroxaban were recently marketed to be used interchangeably with their branded equivalent. However, there have been no previously published studies that directly compared the in vitro anticoagulant effect of branded vs. generic rivaroxaban. The aim of this in vitro study was to compare the effects of three raw rivaroxaban materials, obtained from the branded (Xarelto®) and two generic (Rivarolto® and Rivaroxaban Sandoz®) rivaroxaban formulations on an array of coagulation assays.
Source: www.thrombosisresearch.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 40ScienceDirect - 2 month(s) ago
Recent advances in metabolic assessments, genetic models and imaging techniques have led to rapidly accumulating new evidences regarding the metabolic requirements of hematopoietic homeostasis; however, it remains unclear how specific profiles of metabolism precisely control hematopoiesis. While snapshot single-cell RNA sequencing and lineage tracing models have helped unravel cell-to-cell variations and reconstruct developmental trajectories of hematopoietic stem cells (HSCs), the elucidation of individual bone marrow cell dynamics has been hindered by limits on our ability to isolate fully homogeneous cell populations and the high numbers of starting cells required by current transcriptomic platforms. A widely known model of hematopoiesis suggests that dormant HSCs are metabolically plastic and the activation of mitochondria to meet specific metabolic demands promotes HSC commitment. Recent studies have, however, demonstrated that inactivation of mitochondrial function impairs hemato
Source: www.sciencedirect.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 12
Vol. 21 Issue 12 p3304 – 3316 Nicola J. Mutch Robert L. Medcalf Fibrinolysis is the system primarily responsible for removal of fibrin deposits and blood clots in the vasculature. The terminal enzyme in the pathway, plasmin, is formed from its circulating precursor, plasminogen. Fibrin is by far the most legendary substrate, but plasmin is notoriously prolific and is known to cleave many other proteins and participate in the activation of other proteolytic systems. Fibrinolysis is often overshadowed by
Source: www.jthjournal.orgCategories: General Medicine News, Onc News and JournalsTweet
Read this special collection of review articles honoring the 20th anniversary of the Journal of Thrombosis and Haemostasis. An impressive collection of reviews from world-renowned experts on some of the most important topics in the field. https://t.co/4dm2L4hjWJ @JTHjournal https://t.co/iQsOR6UVNk