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Mashup Score: 12
Vol. 21 Issue 12 p3304 – 3316 Nicola J. Mutch Robert L. Medcalf Fibrinolysis is the system primarily responsible for removal of fibrin deposits and blood clots in the vasculature. The terminal enzyme in the pathway, plasmin, is formed from its circulating precursor, plasminogen. Fibrin is by far the most legendary substrate, but plasmin is notoriously prolific and is known to cleave many other proteins and participate in the activation of other proteolytic systems. Fibrinolysis is often overshadowed by
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Mashup Score: 82023 Year in Review - 2 month(s) ago
The top downloaded, and the top cited, articles published in Research and Practice in Thrombosis and Haemostasis in 2023.
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Mashup Score: 3Involvement of peptidylarginine deiminase 4 in eosinophil extracellular trap formation and contribution to citrullinated histone signal in thrombi - 2 month(s) ago
Extracellular traps formed by neutrophils (NETs) and eosinophils (EETs) have been described in coronary thrombi, contributing to thrombus stability. A key mechanism during NET formation is histone modification by the enzyme PAD4. Citrullinated histones, the product of PAD4 activity, are often attributed to neutrophils. Eosinophils also express high levels of PAD4 but the contribution of PAD4 to EET formation is not known.
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Mashup Score: 8Meet the new JTH Editors Ton Lisman and Suzanne Cannegieter - 3 month(s) ago
Suzanne Cannegieter, M.D., Ph.D., M.Sc., and Ton Lisman, Ph.D., will begin as the new Editors-in-Chief of the Journal of Thrombosis and Haemostasis (JTH) in …
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Mashup Score: 12023 Year in Review - 3 month(s) ago
The top downloaded, the top cited, and the Young Investigators articles published in Experimental Hematology (EXPHEM) in 2023
Source: www.elsevier.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 62023 Year in Review - 3 month(s) ago
The top downloaded, and the top cited, articles published in Research and Practice in Thrombosis and Haemostasis in 2023.
Categories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 12
Vol. 21 Issue 12 p3304 – 3316 Nicola J. Mutch Robert L. Medcalf Fibrinolysis is the system primarily responsible for removal of fibrin deposits and blood clots in the vasculature. The terminal enzyme in the pathway, plasmin, is formed from its circulating precursor, plasminogen. Fibrin is by far the most legendary substrate, but plasmin is notoriously prolific and is known to cleave many other proteins and participate in the activation of other proteolytic systems. Fibrinolysis is often overshadowed by
Source: www.jthjournal.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 31ScienceDirect - 3 month(s) ago
Recent advances in metabolic assessments, genetic models and imaging techniques have led to rapidly accumulating new evidences regarding the metabolic requirements of hematopoietic homeostasis; however, it remains unclear how specific profiles of metabolism precisely control hematopoiesis. While snapshot single-cell RNA sequencing and lineage tracing models have helped unravel cell-to-cell variations and reconstruct developmental trajectories of hematopoietic stem cells (HSCs), the elucidation of individual bone marrow cell dynamics has been hindered by limits on our ability to isolate fully homogeneous cell populations and the high numbers of starting cells required by current transcriptomic platforms. A widely known model of hematopoiesis suggests that dormant HSCs are metabolically plastic and the activation of mitochondria to meet specific metabolic demands promotes HSC commitment. Recent studies have, however, demonstrated that inactivation of mitochondrial function impairs hemato
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Mashup Score: 2Reducing the risk of atherosclerotic cardiovascular disease in people with haemophilia, the importance of primary prevention. - 3 month(s) ago
Revolutionary advances in the treatment of haemophilia has led to a significant improvement in life expectancy. Associated with this has been an increase in age-related diseases especially atherosclerotic cardiovascular disease (CVD). While people with haemophilia (PWH) develop atherosclerosis at rates similar to the general population, rates of atherothrombosis and mortality related to CVD have been much lower, due to their hypocoagulable state. Changing treatment paradigms, aimed at reducing the risk of bleeding by improving haemostasis to levels approaching normality, has meant the protection they are thought to have had may be lost.
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Mashup Score: 15Ex vivo hematopoietic stem cell expansion technologies: recent progress, applications, and open questions - 3 month(s) ago
Hematopoietic stem cells (HSCs) are a rare but potent cell type that support life-long hematopoiesis and stably regenerate the entire blood and immune…
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Read this special collection of review articles honoring the 20th anniversary of the Journal of Thrombosis and Haemostasis. An impressive collection of reviews from world-renowned experts on some of the most important topics in the field. https://t.co/4dm2L4hjWJ @JTHjournal https://t.co/iQsOR6UVNk