-
Mashup Score: 89Siah3 acts as a physiological mitophagy suppressor that facilitates axonal degeneration - 19 hour(s) ago
Signal-induced suppression of mitophagy promotes axon pruning during target innervation.
Source: www.science.orgCategories: General Medicine News, Future of MedicineTweet
-
Mashup Score: 0
An abstract is unavailable.
Source: journals.lww.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Only 28% of acute myeloid leukemia (AML) patients survive beyond 5 years after diagnosis. However, #mitophagy has been identified as a key mechanism that allows #leukemia cells to resist the effects of the widely prescribed drug venetoclax. https://t.co/zIORh7FY4c #AML https://t.co/H70O28WtFX
-
-
Mashup Score: 0
An abstract is unavailable.
Source: journals.lww.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Acute myeloid leukemia (AML) is notoriously difficult to treat. Only 28% of patients survive beyond 5 years. #Mitophagy has been identified as a key mechanism that allows #leukemia cells to resist #venetoclax. Read more: https://t.co/jDm3grCpjW https://t.co/5yVtXtiLHG
-
-
Mashup Score: 8
Mitophagy modulators like MFN2 drive BH3-mimetic resistance in acute myeloid leukemia (AML), and genetic or pharmacologic inhibition of MFN2 improved leukemia cell elimination both in vitro and in preclinical AML patient-derived models.
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
July issue— #Mitophagy Promotes Resistance to BH3 Mimetics in Acute Myeloid #Leukemia. https://t.co/Zz49L09zmd @glytsou @xufeng_chen Emmanouil Zacharioudakis @ProfGavathiotis @iannisaifantis1 @RutgersCancer @ae_cancercenter @EinsteinMed @Perlmutter_CC @NYUGSOM_Path @nyugrossman https://t.co/yxz905K4i4
-
-
Mashup Score: 0The multiple links between actin and mitochondria - Nature Reviews Molecular Cell Biology - 1 year(s) ago
Actin is most frequently associated with cell migration and shape control. However, actin has a multitude of other cellular roles, including regulating the function and dynamics of organelles. This Review discusses a plethora of actin functions in mitochondrial biology.
Source: NatureCategories: Allergy-Immunology, Latest HeadlinesTweet-
✨ICYMI: New #NRMCBReview on the role of actin in mitochondrial biology, e.g., during mitochondrial fission, dysfunction and #mitophagy, or motility. ➡️"The multiple links between actin and mitochondria" by @TakShunFung, @raj_mito and @hhiggslab. https://t.co/LSnJE5bVbE https://t.co/r9iFnsvo7h
-
-
Mashup Score: 12
Abstract. BH3-mimetics are used as an efficient strategy to induce cell death in several blood malignancies, including acute myeloid leukemia (AML). Venetoclax, a potent BCL-2 antagonist, is used clinically in combination with hypomethylating agents for the treatment of AML. Moreover, MCL-1 or dual BCL-2/BCL-xL antagonists are under investigation. Yet, resistance to single or combinatorial…
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet-
#Mitophagy Promotes Resistance to BH3 Mimetics in #AcuteMyeloidLeukemia— by @glytsou, @xufeng_chen, E. Zacharioudakis, @ProfGavathiotis, @iannisaifantis1 et al. https://t.co/vxEg1gbPz2 @RutgersCancer @ae_cancercenter @EinsteinMed @Perlmutter_CC @NYUGSOM_Path @nyugrossman #leusm https://t.co/8F0mzp3Gmz
-
-
Mashup Score: 0Ulk1-dependent alternative mitophagy plays a protective role during pressure overload in the heart - 3 year(s) ago
AbstractAims. Well-controlled mitochondrial homeostasis, including a mitochondria-specific form of autophagy (hereafter referred to as mitophagy), is essential
Source: OUP AcademicCategories: Cardiology News and Journals, Latest HeadlinesTweet-
A path less taken for #mitophagy Ulk1-mediated alternative mitophagy is critical to maintain #mitochondria quality control & #cardiac function in #HeartFailure https://t.co/Yod0mKB8xd @CVR_TomaszGuzik @DrMikeDrozd @glenpyle #HF #autophagy #CardiovascularResearch https://t.co/SE1UmTGEmF
-
-
Mashup Score: 6
Rationale: Obesity-associated cardiomyopathy characterized by hypertrophy and mitochondrial dysfunction. Mitochondrial quality control mechanisms, including mitophagy, are essential for the maintenan
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Tong & colleagues found that alternative #mitophagy protects against cardiac dysfunction in high fat diet fed mice with #obesity. Learn more about how boosting Ulk/Rab-9 mediated autophagy prevents obesity-related #cardiomyopathy https://t.co/34iHypvE6Y @SadoshimaLab https://t.co/vxwm3T66Sn
-
Scientists have discovered a pathway centered on #mitophagy—the breakdown of mitochondria—that helps “prune” tendril-like growths from neurons in the nervous system. @SciSignal https://t.co/ifHWY4fEaZ https://t.co/FWDb0pLewG