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Mashup Score: 1Divergent Actions of Myofibroblast and Myocyte β2-Adrenoceptor in Heart Failure and Fibrotic Remodeling - 1 year(s) ago
Bingqing DengBingqing Deng Department of Pharmacology, University of California at Davis (B.D., Y.Z., C.Z., Y.W., B.X., X.L., Y.K.X.). , Chaoqun ZhuChaoqun Zhu Department of Pharmacology, University of California at Davis (B.D., Y.Z., C.Z., Y.W., B.X., X.L., Y.K.X.). , Eric WeatherfordEric Weatherford Fraternal Order of Eagles Diabetes Research Center and Department of Medicine,…
Source: Circulation ResearchCategories: Endocrinology, Latest HeadlinesTweet
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Mashup Score: 2
Background: Vascular calcification is closely related to the all-cause mortality of cardiovascular events. Basement membrane protein nidogen-2 is a key component of the vascular extracellular matrix
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Chen & colleagues demonstrate a basement membrane protein #nidogen2 as an endogenous inhibitor of #vascular #calcification. Learn more about nidogen-2 as an agonist of the G-protein coupled #LGR4 receptor at https://t.co/L2IAnUGGo0 https://t.co/pTLC55VYnS
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Mashup Score: 0
Background: RBPs (RNA-binding proteins) perform indispensable functions in the post-transcriptional regulation of gene expression. Numerous RBPs have been implicated in cardiac development or physiol
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet-
2/3 Alexander A. Akerberg et al from Boston Children’s Hospital published the study RBPMS2 Is a Myocardial-Enriched Splicing Regulator Required for Cardiac Function https://t.co/zIyYvtC2pS
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Mashup Score: 2
Background: As an integral component of cell membrane repair machinery, MG53 (mitsugumin 53) is important for cardioprotection induced by ischemia preconditioning and postconditioning. However, it al
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet-
3/3 Fengxiang Lv et al from Peking University found that Blocking MG53S255 Phosphorylation Protects Diabetic Heart from Ischemic Injury https://t.co/HC4lccIzay
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Mashup Score: 10
Background: L-type CaV1.2 channels undergo cooperative gating to regulate cell function, although mechanisms are unclear. This study tests the hypothesis that phosphorylation of the CaV1.2 pore-formi
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Martin-Aragón et al found a mechanism for spatial & temporal remodeling of the #ionchannel Cav1.2 in arterial myocytes that alters vascular function in #diabetic #hyperglycemia. Learn more at https://t.co/OiHbL5bPhp @Miguel_MartinAB @mf_navedo @MNCline @MimiM07876085 https://t.co/OCXY7lAK1Z
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Mashup Score: 2
Background: Genome-wide association studies have discovered a link between genetic variants on human chromosome 15q26.1 and increased coronary artery disease (CAD) susceptibility; however, the underl
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Karamanavi et al demonstrate #CAD susceptibility genetic variants on chromosome 15 reduce the expression of the #FES gene & promotes #atherosclerosis. Learn more at https://t.co/v71pVZXsEa @NUSMedicine @CvdNus @unifleicester @swvanderlaan @biohaojie https://t.co/sQmF76vp7R
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Mashup Score: 0
Background: As an integral component of cell membrane repair machinery, MG53 (mitsugumin 53) is important for cardioprotection induced by ischemia preconditioning and postconditioning. However, it al
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Lv et al demonstrates that the phosphorylation mutant of a muscle-specific protein #Mitsugumin53 (MG53-S255A) promotes #cardiomyocyte survival and protects the cells from membrane-damaging insults without altering #diabetes. Learn more at https://t.co/f2awKJPgCp https://t.co/9NkLSRDD88
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Mashup Score: 0The Effect of a Neuronal Nitric Oxide Synthase Inhibitor on Neurovascular Regulation in Humans - 1 year(s) ago
Background: Neurovascular coupling (NVC) is a key process in cerebral blood flow regulation. NVC ensures adequate brain perfusion to changes in local metabolic demands. Neuronal nitric oxide synthase
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet-
O'Gallagher & colleagues demonstrate that #nNOS plays a key role in regulating rapidity of #NeurovascularCoupling response in #humans. Learn more at https://t.co/aoZsk0qPAd @drlpgallagher @draaronphillips @Roman_Roy1 https://t.co/BWCdnHT9rT
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Mashup Score: 0
Background: RBPs (RNA-binding proteins) perform indispensable functions in the post-transcriptional regulation of gene expression. Numerous RBPs have been implicated in cardiac development or physiol
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Akerberg & colleagues discovered that #RBPMS2 is a splicing factor that is essential for #cardiomyocyte #contractility. Learn more at https://t.co/9zKdTnaMam @AlexAkerbergPhD @calum_og @ChrisNguyenPhD @BeerensManu https://t.co/5gzlLAECDL
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Mashup Score: 0
Background: Heart failure with preserved ejection fraction (HFpEF) is a growing health problem without effective therapies. Epidemiological studies indicate that diabetes is a strong risk factor for
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Wu & colleagues found that activation of the longevity gene #SIRT6 could mitigate #diabetes-associated #HeartFailure with preserved ejection fraction or #HFpEF. Learn more at https://t.co/j6QfQotAe6 https://t.co/wgNs1KIXll
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Collaborative study from @kevinyxxiang lab out online in @CircRes. Beta2AR expression and signaling does opposite things in #HeartFailure if active in myocytes (CKO) versus fibroblasts (FKO). @MoPhysiology https://t.co/yVh3GIA3YO