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Mashup Score: 3
An abstract is unavailable.
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 2The Misdiagnosis and Underdiagnosis of Hepatic... : Clinical and Translational Gastroenterology - 3 hour(s) ago
ld cognitive impairment, dementia, and delirium, which have features closely resembling hepatic encephalopathy. Given the similar presentation of these conditions, misdiagnosis can and does occur. Mild cognitive impairment is common in individuals aged ≥50 years and can progress to dementia in those affected. Dementia and hepatic encephalopathy are both characterized by sleep disturbance and cognitive dysfunction, thus differentiating these conditions can be difficult. Furthermore, delirium can disrupt sleep patterns, and liver disease is recognized as a risk factor for its development. As hepatic encephalopathy is a cirrhosis-related complication, determining if a patient has undiagnosed cirrhosis is critical, particularly given the large number of patients with asymptomatic, compensated cirrhosis. Separately, underdiagnosis of minimal hepatic encephalopathy can occur even in patients with diagnosed liver disease, related, in part, to lack of testing. Given the availability of effecti
Source: journals.lww.comCategories: General Medicine News, GastroenterologyTweet-
RT @ACG_CTG: In #CTGjournal: The Misdiagnosis and Underdiagnosis of Hepatic Encephalopathy Patricia Bloom, MD ➡️ https://t.co/nzu5V0Rd7B…
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Mashup Score: 1
vestigate potential sex differences in the analgesic efficacy of pregabalin that may contribute to disparities in human outcomes. Methods: We used a mouse model of chronic widespread muscle pain (CWP) to test the effects of pregabalin on muscle hyperalgesia, nonreflexive pain, and motor behaviors. The CWP pain model combines 2 pH 4.0 saline injections, spaced 5 days apart, into the gastrocnemius muscle and produces bilateral muscle hyperalgesia. Furthermore, we explored sex differences in the mRNA and protein expression of the α2δ-1 subunit of voltage-gated calcium channels in the dorsal horn of the spinal cord and dorsal root ganglia after development of CWP. Results: Pregabalin fully attenuated muscle hyperalgesia bilaterally in male but not female mice with equal motor deficits produced in both sexes. In addition, using the conditioned place preference test, mice of both sexes with CWP spent significantly more time in the pregabalin-paired chamber compared with baseline, but not sig
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Now in #PainReports: “Pregabalin produces analgesia in males but not females in an animal model of chronic widespread muscle pain” by Plumb et al. https://t.co/oiRGjcsUQ2 https://t.co/8shsM2JZ3b
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Mashup Score: 3
An abstract is unavailable.
Source: journals.lww.comCategories: General Medicine News, Oncologists1Tweet-
New research from the home of a patient with acute lymphoblastic leukemia (ALL) in remission show that exposure to products of the fungus alters transcription factors in normal and acute ALL cells and may play a role in leukemogenesis. https://t.co/mh3D48nWkk https://t.co/2OCTrV4l4b
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Mashup Score: 1
ealth (HH) care. This retrospective cohort study included enrollees with diagnoses and 2+ assessments of pain and anxiety between HH admission and discharge. Three sets of linear regression difference-in-reduction analyses assessed the association of pain or anxiety reduction with number of drugs; drug type; and drug combinations in those with daily pain and daily anxiety. Logistic regression analysis assessed the effect of medication number and class on less-than-daily pain or anxiety at HH discharge. A sensitivity analysis using multinomial regression was conducted with a three-level improvement to further determine clinical significance. Of 85,403 HH patients, 43% received opioids, 27% benzodiazepines, 26% gabapentinoids, 32% selective serotonin reuptake inhibitors, and 8% serotonin and norepinephrine reuptake inhibitors (SNRI). Furthermore, 75% had depression, 40% had substance use disorder diagnoses, and 6.9% had PTSD diagnoses. At HH admission, 83%, 35%, and 30% of patients repor
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Now in #PAIN: “Central nervous system active medication use in Medicare enrollees receiving home health care: association with chronic pain and anxiety level” by Raji et al. https://t.co/kjwiAetbZG https://t.co/LSsrGVo826
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Mashup Score: 0Percutaneous Ultrasonic Barbotage: A Novel Approach for... : Current Sports Medicine Reports - 5 hour(s) ago
An abstract is unavailable.
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
A new case report presents the first documented application of percutaneous ultrasonic barbotage in the management of calcific tendinopathy of the rotator cuff in patients who have previously undergone surgical treatment. Read it today: https://t.co/Nk2K4slGDl https://t.co/rLUvASqBDF
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Mashup Score: 0
ng data among glaucoma patients within All of Us. Materials and Methods: We used diagnosis codes to define cohorts of primary glaucoma patients with and without severity staging specified. Descriptive analyses were conducted by presence of disease severity stage. Analysis of missing data was conducted using a set intersection plot and the Little Test of Missing Completely at Random. T tests were performed to evaluate differences. Results: Of 2982 participants, 1714 (57%) did not have glaucoma severity stage specified, and 11 of 23 analyzed variables had missing data. The Little Test indicated data was not missing completely at random (P<0.001). Significant differences existed between the 2 cohorts with respect to age, age of first glaucoma diagnosis, gender, ethnicity, education, income, insurance, history of glaucoma surgery and medication use, and answers regarding the ability to afford eyeglasses and having seen an eye care provider in the last 12 months (all P-values ≤0.01). Conclu
Source: journals.lww.comCategories: General Medicine News, OphthalmologyTweet-
NEW ARTICLE: “Assessment of Missing Data on Glaucoma Severity Among Participants in the NIH All of Us Research Program of the United States” by Acuff, Radha Saseendrakumar, Weinreb, and Baxter. Read more: https://t.co/T0hWabRS5M @WorldGlaucoma #JoG #JournalOfGlaucoma https://t.co/e6kXwCBlaY
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Mashup Score: 0Assessing the Reliability of the Bleeding Assessment Scale... : Pediatric Critical Care Medicine - 6 hour(s) ago
e United States. SUBJECTS: Children ages 0–18 years admitted to participating PICUs from January 1, 2020, to December 31, 2022, with bleeding noted by bedside nurse. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The bleeding events were classified as minimal, moderate, or severe, according to the BASIC definition, by two independent physicians at two different time points. Patient demographic data, laboratory values, and clinical outcomes were collected. Three hundred twenty-eight patients were enrolled. The overall inter-rater reliability was substantial (weighted kappa coefficient, 0.736; 95% CI, 0.683–0.789), and the intra-rater reliability was “almost-perfect” (weighted kappa coefficient, 0.816; 95% CI, 0.769–0.863). The platelet count (p = 0.008), prothrombin time (p = 0.004), activated partial thromboplastin time (p = 0.025), and fibrinogen levels (p = 0.035) were associated with the bleeding severity, but the international normalized ratio was not (p = 0.195). Patients wer
Source: journals.lww.comCategories: General Medicine News, Critical CareTweet-
How reliable is the Bleeding Assessment Scale in Critically Ill Children (BASIC) definition of bleeding severity? Learn what researchers found in this month's Pediatric Critical Care Medicine: https://t.co/KzEOXQHYgu #SCCM https://t.co/AVK5TtcKiw
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Mashup Score: 4
An abstract is unavailable.
Source: journals.lww.comCategories: General Medicine News, Oncologists1Tweet-
An atlas of metastatic progression of gastric adenocarcinoma (GAC) could lead to a detailed understanding of the tumor biology and immunobiology of advanced GAC and prompt the development of novel, more effective therapies. https://t.co/4lY3tYjZQF https://t.co/dWOkSLYyPd
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Mashup Score: 2
ealth (HH) care. This retrospective cohort study included enrollees with diagnoses and 2+ assessments of pain and anxiety between HH admission and discharge. Three sets of linear regression difference-in-reduction analyses assessed the association of pain or anxiety reduction with number of drugs; drug type; and drug combinations in those with daily pain and daily anxiety. Logistic regression analysis assessed the effect of medication number and class on less-than-daily pain or anxiety at HH discharge. A sensitivity analysis using multinomial regression was conducted with a three-level improvement to further determine clinical significance. Of 85,403 HH patients, 43% received opioids, 27% benzodiazepines, 26% gabapentinoids, 32% selective serotonin reuptake inhibitors, and 8% serotonin and norepinephrine reuptake inhibitors (SNRI). Furthermore, 75% had depression, 40% had substance use disorder diagnoses, and 6.9% had PTSD diagnoses. At HH admission, 83%, 35%, and 30% of patients repor
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Now in #PAIN: “Central nervous system active medication use in Medicare enrollees receiving home health care: association with chronic pain and anxiety level” by Raji et al. https://t.co/kjwiAetbZG https://t.co/LSsrGVo826
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#PAIN turns 50 years old in 2025! We invite you to join us in our year-long celebration of the journal's golden anniversary. This editorial from our Editor-in-Chief @kren27 has more information about our plans for the coming year: https://t.co/7czoR2htQv https://t.co/utMSNidEP8