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Mashup Score: 0Single-Cell RNA Sequencing Identifies Response of Renal... : Journal of the American Society of Nephrology - 1 hour(s) ago
se renal lymphatic endothelial cells in quiescent and cisplatin-injured kidneys. Lymphatic endothelial cell gene expression changes were confirmed in ischemia–reperfusion injury and in cultured lymphatic endothelial cells, validating renal lymphatic endothelial cells single-cell RNA sequencing data. This study is the first to describe renal lymphatic endothelial cell heterogeneity and uncovers molecular pathways demonstrating lymphatic endothelial cells regulate the local immune response to AKI. These findings provide insights into previously unidentified molecular pathways for lymphatic endothelial cells and roles that may serve as potential therapeutic targets in limiting the progression of AKI. Background The inflammatory response to AKI likely dictates future kidney health. Lymphatic vessels are responsible for maintaining tissue homeostasis through transport and immunomodulatory roles. Owing to the relative sparsity of lymphatic endothelial cells in the kidney, past sequencing eff
Source: journals.lww.comCategories: General Medicine News, NephrologyTweet
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Mashup Score: 0Two Weeks Versus One Week of Maximal Patient-Intensivist... : Critical Care Medicine - 2 hour(s) ago
site B was in the Northeast. Patients: Patients 18 years old or older admitted to a study ICU between March 1, 2017, and February 28, 2020. Interventions: None. Measurements and Main Results: We applied target trial emulation to compare admission during an intensivist’s first week (as a proxy for 2 wk of maximal continuity) vs. admission during their second week (as a proxy for 1 wk of maximal continuity). Outcomes included hospital mortality, ICU length of stay, and, for mechanically ventilated patients, duration of ventilation. Exploratory outcomes included imaging, echocardiogram, and consultation orders. We used inverse probability weighting to adjust for baseline differences and random-effects meta-analysis to calculate overall effect estimates. Among 2571 patients, 1254 were admitted during an intensivist’s first week and 1317 were admitted during a second week. At sites A and B, hospital mortality rates were 25.8% and 24.2%, median ICU length of stay were 4 and 2 days, and media
Source: journals.lww.comCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 7
An abstract is unavailable.
Source: journals.lww.comCategories: General Medicine News, NeurologyTweet-
More than 1,100 neurology and nearly 200 child neurology residencies were included in #MatchDay2024—and program directors are thrilled neurology is getting the attention it deserves: https://t.co/pGBZi2jrr7 #NeuroTwitter @DrJeffRatliff @EricaSchuyler @CroninNeuro @REMatthewsMD https://t.co/LbAep4uVsB
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Mashup Score: 3
questions related to contrast delivery via the ECMO circuit, and modifications to ECMO settings and scanning techniques, to avoid non-diagnostic CT scans. The approach is described in detail for patients supported on VA ECMO, with the return cannula sited in the femoral artery. Lesser modifications required for veno-venous ECMO (VV ECMO) are included in the supplemental material. Establishing a common understanding between the intensive care clinician, the CT radiographer, and the radiologist, concerning the patient’s blood-flow-physiology, is the overarching goal. Our stepwise approach facilitates clear communication around modifications to the ECMO pump settings, contrast route and rate, as well as the scanning technique, for each individual scenario….
Source: journals.lww.comCategories: General Medicine News, Critical CareTweet
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Mashup Score: 3UpToDate® : Oncology Times - 6 hour(s) ago
An abstract is unavailable.
Source: journals.lww.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 0Recovery Trajectories in Children Requiring 3 or More Days... : Critical Care Medicine - 6 hour(s) ago
Quaternary children’s hospital PICU. PATIENTS: Children without a preexisting tracheostomy who received greater than or equal to 3 days of invasive ventilation, survived hospitalization, and completed greater than or equal to 1 postdischarge data collection. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: We evaluated 144 children measuring HRQL using proxy-report Pediatric Quality of Life Inventory and functional status using the Functional Status Scale (FSS) reflecting preillness baseline, PICU and hospital discharge, and 1, 3, 6, and 12 months after hospital discharge. They had a median age of 5.3 years (interquartile range, 1.1–13.0 yr), 58 (40%) were female, 45 (31%) had a complex chronic condition, and 110 (76%) had normal preillness FSS scores. Respiratory failure etiologies included lung disease (n = 49; 34%), neurologic failure (n = 23; 16%), and septic shock (n = 22; 15%). At 1-month postdischarge, 68 of 122 (56%) reported worsened HRQL and 35 (29%) had a new functional i
Source: journals.lww.comCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 3
s could offer a valuable orientation for long COVID-related research and clinical care. This retrospective cohort study aimed to determine whether having a COPC predicts the onset of long COVID features using US electronic health records and 1:1 propensity score matching without replacement. The study cohorts included (1) people with acute COVID (n = 1,038,402), (2) people with acute influenza (n = 262,092), and (3) a noninfected cohort comprising people with a routine healthcare encounter (n = 1,081,593). Having a COPC increased the risk of long COVID features in all 3 study cohorts. Among those with COVID, having a pre-existing COPC increased the risk by 1.47 (95% CI = 1.46, 1.47). In the influenza cohort, COPCs increased the risk by 1.39 (95% CI = 1.38, 1.40). In the noninfected cohort, COPCs increased the risk by 1.57 (95% CI = 1.56, 1.59). These findings reinforce the likelihood that nociplastic mechanisms play a prominent role in long COVID. Recognizing that this ubiquitous nonsp
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 1Sensitivity and specificity of SS-OCT for detecting macular ... : Journal of Cataract & Refractive Surgery - 7 hour(s) ago
essee, Crossville, TN. Design: Prospective, cross-sectional, observational, examiner-masked. Methods: The study included 132 participants aged 50 years and older, who underwent precataract surgery work-up. All participants underwent fixation check retinal scans using SS-OCT biometer (IOLMaster 700) as well as full macular scans using Cirrus SD-OCT. 3 independent masked examiners evaluated the scans if they were normal or had a suspected pathology. Different measures of diagnostic accuracy were calculated for 3 examiners. Results: True positive rate (sensitivity) ranged from 71.1% (32/45) to 79.2% (42/53), and false negative rate was between 20.8% (11/53) and 28.9% (13/45) for the 3 examiners. True negative rate (specificity) ranged from 86.8% (59/68) to 94.1% (64/68), and false positive rate was between 5.9 (4/68) and 13.2% (9/68). The fitted receiver operating characteristic area ranged from 0.83 to 0.95. Conclusions: Using retinal SS-OCT biometer scans as a replacement of the dedicat
Source: journals.lww.comCategories: General Medicine News, OphthalmologyTweet
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Mashup Score: 0
An abstract is unavailable.
Source: journals.lww.comCategories: General Medicine News, NeurologyTweet-
We’re in a time of transition in #dementia-related care, with biomarker testing allowing for more precise diagnoses and new #Alzheimers therapies changing the treatment game: https://t.co/UHZiK70Cp3 #NeuroTwitter @Penn_Memory @UCSFMedicine @SamGandy @RonPetersenMD @bcmneurology https://t.co/C2jLc6H8Ay
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Mashup Score: 1No Delay in Age of Crawling, Standing or Walking with... : JAAOS - Journal of the American Academy of Orthopaedic Surgeons - 19 hour(s) ago
35 patients were prospectively enrolled to participate and received questionnaires with sequential clinical visits monitoring treatment of their developmental dysplasia of the hip. One-sample Student t-tests assessed differences in milestone attainment age, and the Benjamini-Hochberg procedure was conducted to decrease the false discovery rate. Post hoc power analyses of each test were conducted. The age of achievement of eight early motor milestones were recorded and compared with a previously published cohort of healthy infants. Results: Infants treated with a Pavlik harness achieved four early motor milestones markedly later than the reported age of achievement in a historical control group. These milestones included “roll supine” (5.3 vs. 4.5 months; P = 0.039), “roll prone” (5.7 vs. 5.0 months; P = 0.039), “sit” (6.4 vs. 5.2 months; P < 0.001), and “crawl on stomach” (7.7 vs. 6.6 months; P = 0.039). However, there was no difference in time to achievement of later motor milestones
Source: journals.lww.comCategories: General Medicine News, OrthopedicsTweet
How lymphatics respond to AKI may affect AKI outcomes. This study found that lymphatic endothelial cell gene expression is altered between injury models, suggesting lymphatic endothelial cells respond to AKI may be key in regulating disease progression https://t.co/Ti2LSQUVpp https://t.co/taUltNS5kQ