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Mashup Score: 105Mechanistic Differences between Torsemide and Furosemide : Journal of the American Society of Nephrology - 1 day(s) ago
s due to the kidney’s compensation. Background Torsemide is proposed to have clinically important pharmacokinetic and pharmacodynamic advantages over furosemide. However, clinical outcomes did not differ in the Torsemide Comparison with Furosemide for Management of Heart Failure (TRANSFORM) randomized trial. Methods We conducted a multicenter mechanistic substudy of patients with heart failure randomized to oral furosemide or torsemide (TRANSFORM-Mechanism trial). At baseline and 30 days, participants underwent detailed assessments of pharmacokinetic and pharmacodynamic parameters. Results The TRANSFORM-Mechanism trial enrolled 88 participants. Kidney bioavailability, or the proportion of dose delivered to the tubular site of action, was significantly less with torsemide compared with furosemide (median, 17.1% [interquartile range, 12.3%–23.5%] versus 24.8% [16.6%–34.1%], P < 0.001). Furosemide had a longer duration of kidney drug delivery and natriuresis (P ≤ 0.004 for both). Prescrib
Source: journals.lww.comCategories: General Medicine News, NephrologyTweet
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Mashup Score: 41
izes the current knowledge on autoimmune tubulopathies. We elected to classify tubulopathies according to the segment that is targeted, because this determines, at least in part, the phenotypic presentation. In the proximal tubule, autoantibodies can cause anti-brush border antibody disease, renal Fanconi syndrome, renal proximal tubular acidosis or tubulointerstitial nephritis and uveitis syndrome. Autoantibodies targeting the thick ascending limb of the loop of Henle can cause either acquired Bartter’s syndrome or hypomagnesemia with hypercalciuria, whereas autoantibodies targeting the distal convoluted tubule can cause acquired Gitelman’s syndrome. Finally, renal distal tubular acidosis or nephrogenic diabetes insipidus can be caused by autoantibodies targeting the collecting duct. In most instances, the characterization of the autoantibodies remains incomplete and the pathogenesis of the disease obscure. We believe it is important to increase the awareness of the physicians regardi
Source: journals.lww.comCategories: General Medicine News, NephrologyTweet-
In this article, the authors argue that it is important to increase physician awareness regarding autoantibodies-mediated tubular diseases in order to have a better estimation of the prevalence and improve patient care. https://t.co/I1R7HrVR1W https://t.co/QqSweVSa2s
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Mashup Score: 18N-acetyl-tryptophan in Acute Kidney Injury after Cardiac... : Journal of the American Society of Nephrology - 6 day(s) ago
cute kidney injury (AKI) following cardiac surgery were enrolled. High-performance liquid chromatography coupled with mass spectrometry was used for untargeted analysis of metabolites in plasma, identifying significant differential metabolites. Subsequently, a tandem liquid chromatography-mass spectrometry–based approach using isotope-labeled standard addition was performed for targeted analysis of the metabolic marker N-acetyl-tryptophan. The function of N-acetyl-tryptophan was determined using different kidney injury mouse models and epithelial cellular models. Transcriptome sequencing, surface plasmon resonance and protein mutation were employed to explore the mechanism of N-acetyl-tryptophan on the kidney. Results: We identified a total of 32 differential metabolites related to AKI occurrence based on a cohort of 1042 patients. Among them, N-acetyl-tryptophan was elevated in plasma of patients with cardiac surgery-associated acute kidney injury compared with those who do not develo
Source: journals.lww.comCategories: General Medicine News, NephrologyTweet-
Cardiac surgery-associated acute kidney injury is a common serious complication after cardiac surgery. This study found that N-acetyl-tryptophan plays a key role in kidney protection. https://t.co/Eohdy7MWzY #basicscience https://t.co/EA5PRCBhNb
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Mashup Score: 5The Physicochemical Approach to Acid–Base Balance: A... : Journal of the American Society of Nephrology - 7 day(s) ago
An abstract is unavailable.
Source: journals.lww.comCategories: General Medicine News, NephrologyTweet-
The analysis of acid–base disorders uses several approaches. In this perspective, the authors critically appraise the physicochemical approach to shed light on some overlooked misconceptions and flaws. https://t.co/bQHFYjFqxC
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Mashup Score: 9Biomarker Panels for Discriminating Risk of CKD Progression ... : Journal of the American Society of Nephrology - 12 day(s) ago
re each independently associated with CKD progression in children. In this study, we used bootstrapped survival trees to identify a combination of biomarkers to predict CKD progression in children. Methods: The CKiD Cohort Study prospectively enrolled children 6 months to 16 years old with an eGFR of 30-90 ml/min/1.73m2. We measured biomarkers in stored plasma and urine collected 5 months after study enrollment. The primary outcome of CKD progression was a composite of 50% eGFR decline or kidney failure. We constructed a regression tree-based model for predicting the time to the composite event, using a panel of clinically relevant biomarkers with empirically derived thresholds, in addition to conventional risk factors. Results: Of the 599 children included, the median age was 12 years [IQR, 8 – 15], 371 (62%) were male, baseline urine protein to creatinine ratio was 0.33 [IQR: 0.12 – 0.95] mg/mg, and baseline eGFR was 53 [IQR, 40 – 66] ml/min/1.73m2. Overall, 205 (34%) children reache
Source: journals.lww.comCategories: General Medicine News, NephrologyTweet-
In this study, the authors used bootstrapped survival trees to identify a combination of biomarkers to predict CKD progression in children. https://t.co/onlNGBunBI @EpiAli @fperrywilson @funsocdoc @JasonHenryG @kidneydrchirag @ogutierrez136 @shlipak_khrc @waikarss… https://t.co/PgQ3Gu3e6G https://t.co/xqS79vmuNy
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Mashup Score: 2Adaptive Designs for Clinical Trials in Nephrology : Journal of the American Society of Nephrology - 16 day(s) ago
An abstract is unavailable.
Source: journals.lww.comCategories: General Medicine News, NephrologyTweet-
In this article, @jardine_meg and @KrishRathika discusses the benefits and challenges of adaptive designs for clinical trials for kidney diseases like calciphylaxis. https://t.co/MGfxbZT53O https://t.co/yQibAanEVA
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Mashup Score: 6The Physicochemical Approach to Acid–Base Balance: A... : Journal of the American Society of Nephrology - 17 day(s) ago
An abstract is unavailable.
Source: journals.lww.comCategories: General Medicine News, NephrologyTweet-
The analysis of acid–base disorders uses several approaches. In this perspective, the authors critically appraise the physicochemical approach to shed light on some overlooked misconceptions and flaws. https://t.co/bQHFYjFqxC
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Mashup Score: 2Damage-Associated Molecular Patterns and Pattern... : Journal of the American Society of Nephrology - 19 day(s) ago
ocytes have not been fully elucidated. Damage-associated molecular patterns (DAMPs) are endogenous danger molecules released from damaged cells, including podocytes, and can elicit an inflammatory response and recruit immune cells to areas of injury. This is performed through binding to pattern recognition receptors. Believed largely to be protective and responsive to injury or infection, recent evidence suggests signaling through DAMP pathways can aggravate and promote chronic diseases already associated with inflammation. The purpose of this narrative review was to highlight current knowledge with respect to specific podocyte DAMPs and pattern recognition receptors and to provide insight into ongoing work and possible future research avenues to advance our understanding of podocyte immune mechanisms….
Source: journals.lww.comCategories: General Medicine News, NephrologyTweet-
Several groups have linked inappropriate innate immune signaling to podocyte injury, particularly chronic, sustained injury. This narrative review highlights current knowledge with respect to specific podocyte DAMPs and PRRs. https://t.co/aumcjYvjZP @DSchnekenB https://t.co/kkKooMtGjA
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Mashup Score: 19Opioid Prescriptions for US Patients Undergoing Long-Term... : Journal of the American Society of Nephrology - 24 day(s) ago
ith kidney failure, but opioid medication prescriptions are associated with morbidity and mortality. The Centers for Disease Control and Prevention issued opioid prescription guidelines in 2016 and 2022, associated with dramatically decreased prescription rates in the United States. It is critical to know whether nationwide opioid prescription rates for patients with kidney failure have decreased. Methods We analyzed the United States Renal Data System database from 2011 to 2020 to describe trends in the proportion of patients with ESKD who received one or more, or long-term, opioid prescriptions, examined factors associated with long-term opioid prescriptions, and evaluated associations of all-cause death with short-term or long-term opioid prescriptions. Results From 2011 to 2022, the percentage of patients with kidney failure (dialysis and kidney transplant) who received at least one or more, or who had received long-term, opioid medication prescriptions decreased steadily, from 60%
Source: journals.lww.comCategories: General Medicine News, NephrologyTweet-
Pain is important for patients with kidney failure, but opioid medication prescriptions are associated with morbidity and mortality. This study found that the opioid prescription rates of patients with ESKD decreased between 2011 and 2020. https://t.co/ghUCE2ETm7 @Tom_Nolin https://t.co/fcC6rpLPUQ
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Mashup Score: 82Mechanistic Differences between Torsemide and Furosemide : Journal of the American Society of Nephrology - 25 day(s) ago
s due to the kidney’s compensation. Background Torsemide is proposed to have clinically important pharmacokinetic and pharmacodynamic advantages over furosemide. However, clinical outcomes did not differ in the Torsemide Comparison with Furosemide for Management of Heart Failure (TRANSFORM) randomized trial. Methods We conducted a multicenter mechanistic substudy of patients with heart failure randomized to oral furosemide or torsemide (TRANSFORM-Mechanism trial). At baseline and 30 days, participants underwent detailed assessments of pharmacokinetic and pharmacodynamic parameters. Results The TRANSFORM-Mechanism trial enrolled 88 participants. Kidney bioavailability, or the proportion of dose delivered to the tubular site of action, was significantly less with torsemide compared with furosemide (median, 17.1% [interquartile range, 12.3%–23.5%] versus 24.8% [16.6%–34.1%], P < 0.001). Furosemide had a longer duration of kidney drug delivery and natriuresis (P ≤ 0.004 for both). Prescrib
Source: journals.lww.comCategories: General Medicine News, NephrologyTweet-
Torsemide is proposed to have clinically important pharmacokinetic and pharmacodynamic advantages over furosemide. This study found no meaningful pharmacokinetic/pharmacodynamic advantages for torsemide versus furosemide. https://t.co/uvXjwFQnVk @ClevelandClinic @CleClinicMD… https://t.co/kVH7ril8mX https://t.co/WCWMS6TIUf
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Torsemide is proposed to have clinically important pharmacokinetic and pharmacodynamic advantages over furosemide. This study found no meaningful pharmacokinetic/pharmacodynamic advantages for torsemide versus furosemide. https://t.co/uvXjwFQnVk @ClevelandClinic @CleClinicMD… https://t.co/kVH7ril8mX https://t.co/WCWMS6TIUf