-
Mashup Score: 1
Purpose: To screen myocilin mutations in a large South Indian family with early-onset JOAG and adult-onset POAG Methods: In a large South Indian family with 20 members, 8 members diagnosed as JOAG, 7 members as POAG, 4 members as JOAG suspect, and 1 member as POAG suspect were screened for myocilin (MYOC) mutations using Sanger sequencing. Whole exome sequencing was performed on clinically suspected JOAG/POAG individuals. Results: Myocilin gene mutation N480K (c.1440C>G) was detected in 20 family members, including proband, of whom 8 were JOAG and 7 were POAG patients, 3 were JOAG suspects, and 2 were unaffected. Among the unaffected carriers, 1 was less than 5 years old, and another was 25 years old. The earliest to develop the disease was a 10-year-old child. The penetrance of the mutation was 95% over 10 years of age. This family had JOAG/POAG suspects with no N480K MYOC mutation, and they were further screened for other mutations using whole-exome sequencing. Polymorphisms CYP1B1 L
Source: journals.lww.comCategories: General Medicine News, OphthalmologyTweet
-
Mashup Score: 1Diode Laser Transscleral Cyclophotocoagulation With a Novel ... : Journal of Glaucoma - 1 month(s) ago
ow-cost torchlight method in refractory pediatric glaucoma. Methods: This prospective interventional study included children with refractory glaucoma who underwent TSCPC with the Oculight laser system (IRIS Medical Instruments) with trans-corneal TI (TSCPC-TI) using a novel low-cost torchlight method. Children completing a minimum 1-year follow-up were analyzed. They were compared with a historical control group of children who underwent TSCPC without TI (TSCPC-No-TI) at the 1-year follow-up period. We analyzed the mean laser energy delivered, post-laser intraocular pressure reduction, number of antiglaucoma medications (AGM), the requirement of retreatment and complications of the procedure in both groups. Results: Forty-two eyes of 35 patients comprised the TSCPC-TI group and were compared with 31 eyes of 21 patients in the TSCPC-No-TI group. The TSCPC-TI group required lower energy than the TSCPC-No-TI group (24.7±7.8 J vs. 47.2±10.9 J, P<0.0001). Mean topical antiglaucoma drug requ
Source: journals.lww.comCategories: General Medicine News, OphthalmologyTweet-
NEW ARTICLE: “Diode Laser Transscleral Cyclophotocoagulation With a Novel Low-Cost Torchlight Method of Trans-Corneal Transillumination in Refractory Pediatric Glaucoma” by Choudhary, Snehi, Singh et al. Read more: https://t.co/62YynromwL @WorldGlaucoma #JoG #JournalOfGlaucoma https://t.co/AeC1Nkh5ix
-
-
Mashup Score: 1
he purpose of this study was to evaluate pharmacological dilatation with one drop of 1% tropicamide on pupillary diameter and IOP changes in patients with PXS and glaucoma (PXG). Materials and Methods: Eighty-two patients with PXS, 78 Patients with PXG, and 35 healthy subjects were included in the study. PXG and PXS were diagnosed based on IOP assessment, corneal pachymetry, optic disc examination, visual field testing, and peripapillary retinal nerve fiber analysis. IOP and the diameter of pupil size were measured before dilatation and at postdilatation first, second, and fourth hours. Results: The mean pupillary diameter values at postdilatation second and fourth hours were statistically significantly different between the patients with PXS and PXG (P<0.001, for each). Also, there were significant differences between the PXS group and the control group in terms of the mean pupillary diameter values at predilatation and postdilatation at the first hour and postdilatation second hour (
Source: journals.lww.comCategories: General Medicine News, OphthalmologyTweet
-
Mashup Score: 5Ocular Biometric Characteristics in Preoperative Diagnosis... : Journal of Glaucoma - 1 month(s) ago
characteristics of eyes with AAC with zonular laxity to further explore the sensitive parameters for preoperative diagnosis. Methods: This study included 50 patients with AAC with zonular laxity and 54 patients with AAC without zonular laxity. Demographic data, ocular examination results, and biometric parameters on ultrasound biomicroscopy images were compared between the affected and fellow eyes in 2 groups. Parameters significant in the multiple linear regression model were included in a regression equation and the diagnostic efficiency was evaluated by area under the curve. Results: In patients with AAC with zonular laxity, the binocular difference of central ACD, LV in affected eyes, and binocular difference of the LV were significantly larger than those in patients without zonular laxity respectively and these three parameters were all significant in multiple linear regression analysis (all P<0.001). The area under the curve of binocular difference of ACD, LV in affected eyes, an
Source: journals.lww.comCategories: General Medicine News, OphthalmologyTweet
-
Mashup Score: 5
Précis: Reading results in a rise in intraocular pressure (IOP) which is greater while using smar
Source: journals.lww.comCategories: General Medicine News, OphthalmologyTweet
-
Mashup Score: 1Reliability of Measurements Using Ocular Response Analyzer... : Journal of Glaucoma - 1 month(s) ago
eliability when the ORA is used as a screening tonometer, and to compare CH measurements in eyes with and those without glaucomatous changes in the fundus. Patients and Methods: 1488 eyes of 747 patients (mean age: 53.5 ± 20.4 y, range: 6–94 y) underwent intraocular pressure (IOP) measurement using ORA as screening. The percentage of eyes with a waveform score ≥6, the recommended threshold indicating reliability, was calculated. Eyes that had waveform score ≥6 and had undergone fundus photography and optical coherence tomography were assessed for the presence or absence of glaucomatous changes in fundus from optical coherence tomography and fundus images, and CH was compared between the 2 groups. Results: Mean ± SD (range) of ORA measurements were: Goldmann-correlated IOP 14.9 ± 4.8 (1.0–63.2) mm Hg, corneal-compensated IOP 16.2 ± 4.7 (3.2–73.6) mm Hg, CH 9.7 ± 1.5 (0.0–20.6) mm Hg, and waveform score 7.3 ± 1.5 (0.1–9.7). Eighty-four percent of eyes had a waveform score ≥6. Among 192 e
Source: journals.lww.comCategories: General Medicine News, OphthalmologyTweet-
NEW ARTICLE: “Reliability of Measurements Using Ocular Response Analyzer as a Screening Tonometer and Corneal Hysteresis Values in the Presence or Absence of Glaucomatous Changes in Fundus” by Maruyama, Sugiura, and Taki. Read more: https://t.co/wCsRhfY9IR @WorldGlaucoma #JoG https://t.co/yCgeJcNr9H
-
-
Mashup Score: 2
The purpose of this study was to evaluate the long-term effectiveness of iTrack (Nova Eye Medical Inc.) ab-interno canaloplasty for reducing IOP and the number of glaucoma medications in patients with primary open angle (POAG) and pseudoexfoliative glaucoma. Methods: A retrospective single-center consecutive case series. Patients were treated with either ab-interno canaloplasty performed as a stand-alone procedure or combined with cataract surgery and were followed for up to 6 years. iTrack was used to circumferentially catheterize and viscodilate the Schlemm canal over 360 degrees. Primary efficacy endpoints included IOP and number of glaucoma medications at 12, 24, 36, 48, 60, and 72 months after surgery. Results: Twenty-seven eyes of 22 patients, with a mean age of 76.9±6.3 years, were recruited. Mean IOP was reduced significantly from 19.9±5.2 mm Hg (n=27) at baseline (no washout) to 14.6±3.3 mm Hg at the 6-year follow-up (n=18; P<0.001). The number of medications was significantly
Source: journals.lww.comCategories: General Medicine News, OphthalmologyTweet
-
Mashup Score: 1
e points for estimating disease progression. Patients: A total of 96 patients with newly diagnosed exfoliation glaucoma were included. Included patients were required to perform at least 7 visual field tests within a 3-year period (±3 months). All patients were treated at inclusion. Methods: This was a nonrandomized, prospective cohort study. The predictors measured included IOP, mean deviation (MD), and visual field index (VFI). Progression was assessed using the rate of progression based on MD, VFI, and “Guided Progression Analysis.” Linear or logistic regression models were developed based on the variables studied. An analysis of variance was used to establish the earliest time point. At the earliest time point, the models were retested. The area under the receiver operating characteristic curve was calculated. Results: The general rate of progression of the cohort was −3.84 (±2.61) dB for the MD values and 9.66 (±6.25) % for the VFI values over 3 years. The IOP, MD, and VFI values
Source: journals.lww.comCategories: General Medicine News, OphthalmologyTweet
-
Mashup Score: 0Comparison Between 24-2 ZEST and 24-2 ZEST FAST Strategies... : Journal of Glaucoma - 2 month(s) ago
im of this study was to compare the test duration of ZEST strategy with ZEST FAST and to evaluate the test-retest variability of ZEST FAST strategy on patients with glaucoma and ocular hypertension. Patients and Methods: This was a multicenter retrospective study. We analyzed 1 eye of 60 subjects: 30 glaucoma patients and 30 patients with ocular hypertension. For each eye we analyzed, 3 visual field examinations were performed with Compass 24-2 grid: 1 test performed with ZEST strategy and 2 tests performed with ZEST FAST. Mean examination time and mean sensitivity between the 2 strategies were computed. ZEST FAST test-retest variability was examined. Results: In the ocular hypertension cohort, test time was 223±29 seconds with ZEST FAST and 362±48 seconds with ZEST (38% reduction, P<0.001). In glaucoma patients, it was respectively 265±62 and 386±78 seconds (31% reduction using ZEST FAST, P<0.001). The difference in mean sensitivity between the 2 strategies was −0.24±1.30 dB for ocula
Source: journals.lww.comCategories: General Medicine News, OphthalmologyTweet
-
Mashup Score: 0Comparison of Patterns of Structural Progression in Primary ... : Journal of Glaucoma - 2 month(s) ago
iber layer (RNFL) and macular ganglion cell-inner plexiform layer (GCIPL) thinning by guided progression analysis (GPA) of optical coherence tomography (OCT) in primary open angle glaucoma (POAG) and pseudoexfoliation glaucoma (PXG). Materials and Methods: The progression of RNFL and GCIPL thinning was assessed by the GPA of Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA). By overlaying the acquired images of the RNFL and GCIPL thickness-change maps, the topographic patterns of progressive RNFL and GCIPL thinning were evaluated. The rates of progression of RNFL and GCIPL thinning were analyzed and compared between patients with POAG and those with PXG. Results: Of the 248 eyes of 248 patients with POAG (175 eyes of 175 patients) or PXG (73 eyes of 73 patients) enrolled, 156 POAG eyes and 48 PXG eyes were included. Progressive RNFL thinning was significantly more common in PXG than in POAG (P=0.005). According to the RNFL progression-frequency maps, progression appeared mainly in the sup
Source: journals.lww.comCategories: General Medicine News, OphthalmologyTweet
NEW ARTICLE: “Myocilin Mutation N480K Leads to Early Onset Juvenile and Adult-onset Primary Open Angle Glaucoma in a Six Generation Family” by Kader, Devajaran, Vijayan et al. Read more: https://t.co/oT41Hh5VV3 @WorldGlaucoma #JoG #JournalOfGlaucoma https://t.co/3bjE58gBMy