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Mashup Score: 121
Division of labor among resident tissue macrophages is vital for proper tissue function during homeostasis.
Source: www.science.orgCategories: General Medicine News, Future of MedicineTweet
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Mashup Score: 121
Division of labor among resident tissue macrophages is vital for proper tissue function during homeostasis.
Source: www.science.orgCategories: General Medicine News, Future of MedicineTweet
-
Mashup Score: 121
Division of labor among resident tissue macrophages is vital for proper tissue function during homeostasis.
Source: www.science.orgCategories: General Medicine News, Future of MedicineTweet
-
Mashup Score: 121
Division of labor among resident tissue macrophages is vital for proper tissue function during homeostasis.
Source: www.science.orgCategories: General Medicine News, Future of MedicineTweet
-
Mashup Score: 121
Division of labor among resident tissue macrophages is vital for proper tissue function during homeostasis.
Source: www.science.orgCategories: General Medicine News, Future of MedicineTweet
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Mashup Score: 168
Division of labor among resident tissue macrophages is vital for proper tissue function during homeostasis.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 162
Division of labor among resident tissue macrophages is vital for proper tissue function during homeostasis.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 0Spatial and temporal mapping of breast cancer lung metastases identify TREM2 macrophages as regulators of the metastatic boundary - 7 month(s) ago
Abstract. Cancer mortality primarily stems from metastatic recurrence, emphasizing the urgent need for developing effective metastasis targeted immunotherapies. To better understand the cellular and molecular events shaping metastatic niches, we used a spontaneous breast cancer lung metastasis model to create a single-cell atlas spanning different metastatic stages and regions. We found that pre-metastatic lungs are infiltrated by inflammatory neutrophils and monocytes, followed by accumulation of suppressive macrophages with the emergence of metastases. Spatial profiling revealed that metastasis-associated immune cells were present in the metastasis core, with the exception of TREM2+ regulatory macrophages uniquely enriched at the metastatic invasive margin, consistent across both murine models and human patient samples. These regulatory macrophages (Mreg) contribute to the formation of an immune-suppressive niche, cloaking tumor cells from immune surveillance. Our study provides a co
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Spatial & Temporal Mapping of #BreastCancer Lung Metastases Identify TREM2 #Macrophages as Regulators of the Metastatic Boundary, by @IdoYofe @ShamiTamar, Noam Cohen, Tomer Landsberger, @ErezNeta, @IdoAmitLab et al. https://t.co/iBqDFBU2KY @WeizmannScience @TelAvivUni #Metastasis https://t.co/JY1wVUdAyD
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Mashup Score: 8Spatial and temporal mapping of breast cancer lung metastases identify TREM2 macrophages as regulators of the metastatic boundary - 7 month(s) ago
Abstract. Cancer mortality primarily stems from metastatic recurrence, emphasizing the urgent need for developing effective metastasis targeted immunotherapies. To better understand the cellular and molecular events shaping metastatic niches, we used a spontaneous breast cancer lung metastasis model to create a single-cell atlas spanning different metastatic stages and regions. We found that pre-metastatic lungs are infiltrated by inflammatory neutrophils and monocytes, followed by accumulation of suppressive macrophages with the emergence of metastases. Spatial profiling revealed that metastasis-associated immune cells were present in the metastasis core, with the exception of TREM2+ regulatory macrophages uniquely enriched at the metastatic invasive margin, consistent across both murine models and human patient samples. These regulatory macrophages (Mreg) contribute to the formation of an immune-suppressive niche, cloaking tumor cells from immune surveillance. Our study provides a co
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Spatial & Temporal Mapping of #BreastCancer Lung Metastases Identify TREM2 #Macrophages as Regulators of the Metastatic Boundary, by @IdoYofe @ShamiTamar, Noam Cohen, Tomer Landsberger, @ErezNeta, @IdoAmitLab et al. https://t.co/YlACKewCgv @WeizmannScience @TelAvivUni #Metastasis https://t.co/ovY4dimzeG
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Mashup Score: 0
Chakraborty et al. demonstrate that a subset of tissue-resident alveolar macrophages shows greater capacity for efferocytosis and prevents hyperinflammation fol
Source: rupress.orgCategories: Infectious Disease, Latest HeadlinesTweet-
🏋️ How to train your immune cells! Scientists with Dr. @jalees_rehman at @UIC_BMG studied lung-resident alveolar #macrophages (AMs) with trained immunity and observed that trained AMs showed greater resilience to #pathogen-induced cell death. @JExpMed | https://t.co/khoosAgkrb https://t.co/wC3or6OFtL
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In a new @SciImmunology Review, scientists discuss how resident tissue #macrophages go beyond immunity to keep organs thriving. https://t.co/mApUmuomGx https://t.co/ohKQGnQhIv