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Mashup Score: 2Structural details of a Class B GPCR-arrestin complex revealed by genetically encoded crosslinkers in living cells - Nature Communications - 1 year(s) ago
The conformation of GPCR-arrestin complexes at the cell membrane, despite available structures, remains uncertain. This work reveals structure and dynamics of the PTH1R-arrestin2 complex, including flexible regions, in live cells.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 0Understanding VPAC receptor family peptide binding and selectivity - Nature Communications - 1 year(s) ago
Previously, peptide selectivity in the VPAC receptor family of GPCRs was poorly understood. Here, authors combine cryo-EM and MD data to understand binding and selectivity of VPAC1R and PAC1R peptide agonists that can guide future drug development.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
"The authors @SarahJ_Piper, @PatrickMSexton1, @denise_wootten and others from @CCeMMP, @MIPS_DDB report insights into the binding and selectivity of VPAC1R and PAC1R peptide agonists #GPCR #CryoEM https://t.co/B4Za1mpGY3 https://t.co/Q3GLWA5GDy
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Mashup Score: 4
Welcome! You are invited to join a webinar: Frontiers in Cardiovascular Science Seminar. After registering, you will receive a confirmation email about joining the webinar.
Source: ZoomCategories: Cardiologists, Latest HeadlinesTweet-
Please join @StanfordCVI seminar on Tue 11/15 at 12-1pm PST by Brian Kobilka @Stanford_MCP (@NobelPrize for #GPCR) speak on #opiod receptor agonists. Zoom link: https://t.co/oD1xyw95rv @StanfordDeptMed @StanCVFellows @Stanford_ChEMH @ISHR_NAS @VascularBiol @SeanM_Wu @CardioNerds https://t.co/1cULdPrBmT
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Mashup Score: 1A New, Non-Addictive Pain Killer With Fewer Side Effects - 2 year(s) ago
A promising new non-opioid painkiller (analgesic) has been discovered, with potentially fewer side effects than other potent painkillers. A team of researchers led by scientists from the University of Warwick’s School of Life Sciences has analyzed a compound known as BnOCPA (benzyloxy-cyclopentylad
Source: SciTechDailyCategories: Healthcare Professionals, Latest HeadlinesTweet-
New, Non-Addictive #Pain Killer w Fewer Side Effects - https://t.co/tSAbLor5Q0 Selective activation of #Gαob by an #adenosine A1 receptor [#A1R] agonist [#BnOCPA] elicits analgesia.. @NatureComms #Gprotein #GPCR potent #analgesia w/o sedation, motor impairment or cardiac effects https://t.co/9zTXJ0v047
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Mashup Score: 2LPA2 Contributes to Vascular Endothelium Homeostasis and Cardiac Remodeling After Myocardial Infarction - 2 year(s) ago
Rationale: Myocardial infarction (MI) is one of the most dangerous adverse cardiovascular events. Our previous study found that lysophosphatidic acid (LPA) is increased in human peripheral blood afte
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Pei & colleagues found #LPA2, a canonical #GPCR, is a new potential target for maintaining #vascular homeostasis and ameliorating ischemic heart injury. Learn more at https://t.co/WDNaiJdehA https://t.co/l3TPLjyRqZ
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Mashup Score: 4
Receptor-mediated β-arrestin activation requires relief of autoinhibition mediated by the respective C-terminal tails of the β2-adrenergic receptor and β-arrestin1. These processes depend not only on the degree of receptor tail phosphorylation but also on concurrent agonist-mediated receptor activation.
Source: CellCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
In the latest issue! GPCR-mediated b-arrestin activation deconvoluted with single-molecule precision! #sciencetwitter #GPCR @Columbia @ColumbiaPS https://t.co/xzKM87gj8T https://t.co/ACk0w7K8XB
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Mashup Score: 0Medicinal Chemistry Approaches To GPCR Drug Discovery - 2 year(s) ago
Friedman Brain Institute at Mount Sinai researchers using novel approaches to find new drug targets for brain disorders
Source: reports.mountsinai.orgCategories: Latest Headlines, NeurologyTweet-
In the LATEST #FBINewsletter, LEARN HOW @filizolalab1 & Jian Jin, PhD are making tremendous strides in leveraging novel modes of #GPCR drug discovery giving @IcahnMountSinai unparalleled opportunities to discover treatment for #CNS disorders. READ MORE👉https://t.co/3UFBHw8h3W https://t.co/f5PG4JhrN3
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Mashup Score: 0Scientists illuminate mechanism of common drug target - 2 year(s) ago
Using advanced imaging methods, researchers have gained insight into how a common target of drugs sends cellular signals, a finding that may lead to better and more precise therapeutics.
Source: EurekAlert!Categories: Healthcare Professionals, Latest HeadlinesTweet-
HUGE: Scientists illuminate mechanism of common drug target https://t.co/MeBKvrCC7s #singlemolecule #FRET #smFRET #Gproteins @CellCellPress: #GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision https://t.co/J4K99RF0GH
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Mashup Score: 16
Receptor-mediated β-arrestin activation requires relief of autoinhibition mediated by the respective C-terminal tails of the β2-adrenergic receptor and β-arrestin1. These processes depend not only on the degree of receptor tail phosphorylation but also on concurrent agonist-mediated receptor activation.
Source: CellCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
Now online! GPCR-mediated b-arrestin activation deconvoluted with single-molecule precision! #sciencetwitter #GPCR https://t.co/ymruxql2Uv https://t.co/CvkXNKdDsu
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Mashup Score: 0Exploration of the dynamic interplay between lipids and membrane proteins by hydrostatic pressure - Nature Communications - 2 year(s) ago
Direct information on the dynamic interplay between membrane proteins and lipids is scarce. Here the authors report a detailed description of these close relationships by combining lipid nanodiscs and high-pressure NMR. They report the link between pressure and lipid compositions to the conformational landscape of the β-barrel OmpX and the α-helical BLT2 G Protein-Coupled Receptor in nanodiscs.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
Researchers from @ICSN_lab @MirouxLab describe the dynamic interplay between membrane proteins and lipids by high-pressure NMR. @EwenLescop @UnivParisSaclay @cnrs @Terence_Strick @nadia_izadi @mjwnilges @eric_leonardis #NMRchat #High-Pressure #GPCR https://t.co/lwpDHrxEAp https://t.co/j6P1wbdMka
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Photocrosslinking reveals structure and dynamics of the PTH1R-arrestin2 complex, including flexible regions, in live cells. @sevakat1, #GPCR, #arrestin https://t.co/9PnUiyt9yu https://t.co/ai2xARp7c3