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Mashup Score: 154Time is ticking faster for long genes in aging - 1 month(s) ago
Recent studies of aging organisms have identified a systematic phenomenon, characterized by a negative correlation between gene length and their expression in various cell types, species, and diseases. We term this phenomenon gene-length-dependent transcription decline (GLTD) and suggest that it may represent a bottleneck in the transcription machinery and thereby significantly contribute to aging as an etiological factor. We review potential links between GLTD and key aging processes such as DNA damage and explore their potential in identifying disease modification targets. Notably, in Alzheimer’s disease, GLTD spotlights extremely long synaptic genes at chromosomal fragile sites (CFSs) and their vulnerability to postmitotic DNA damage. We suggest that GLTD is an integral element of biological aging.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 130Time is ticking faster for long genes in aging - 1 month(s) ago
Recent studies of aging organisms have identified a systematic phenomenon, characterized by a negative correlation between gene length and their expression in various cell types, species, and diseases. We term this phenomenon gene-length-dependent transcription decline (GLTD) and suggest that it may represent a bottleneck in the transcription machinery and thereby significantly contribute to aging as an etiological factor. We review potential links between GLTD and key aging processes such as DNA damage and explore their potential in identifying disease modification targets. Notably, in Alzheimer’s disease, GLTD spotlights extremely long synaptic genes at chromosomal fragile sites (CFSs) and their vulnerability to postmitotic DNA damage. We suggest that GLTD is an integral element of biological aging.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet-
Researchers argue that long #genes age faster -- and this quirk may play a role in how people age. Read more from this Opinion in @TrendsGenetics: https://t.co/BbkXDw8lS4 @tecnun Ander Izeta, @MolecularGenet3 Jan H.J. Hoeijmakers, @NUFeinbergMed Thomas Stoeger https://t.co/ZP1ChBpZwz
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Mashup Score: 29New tool improves the search for genes that cause diseases - 3 month(s) ago
A new statistical tool developed by researchers at the University of Chicago improves the ability to find genetic variants that cause disease. The tool, described in a new paper published January 26, …
Source: medicalxpress.comCategories: General Medicine News, General HCPsTweet-
New tool improves the search for #genes that cause diseases @NatureGenet https://t.co/FC2Kc3UYot
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Mashup Score: 10Stage-specific dynamic reorganization of genome topology shapes transcriptional neighborhoods in developing human retinal organoids - 5 month(s) ago
We have generated a high-resolution Hi-C map of developing human retinal organoids to elucidate spatiotemporal dynamics of genomic architecture and it…
Source: www.sciencedirect.comCategories: General Medicine News, General HCPsTweet-
Study shows how #genes in retina are regulated during development @NIHforHealth @CellReports https://t.co/fUZW1xYij8 https://t.co/vkVbCyTIgP
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Mashup Score: 0Scientists identify genes linked to high production of key antibody - 8 month(s) ago
Researchers studying white blood cells identified an atlas of genes linked to high production and release of the most common type of antibody found in the human body, known as immunoglobulin G. The finding could be a step toward new antibody-based treatments and improvements in the effectiveness of cell therapies. The researchers used microscopic containers called nanovials, which were developed at UCLA, to capture the individual cells they studied.
Source: www.eurekalert.orgCategories: General Medicine News, Latest HeadlinesTweet-
Scientists identify #genes linked to high production of key antibody @cnsiatucla #discoveryresearch #immunology https://t.co/nSuBeLlPhG
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Mashup Score: 0Experimental insulin implant uses electricity to control genes - 9 month(s) ago
Nature – Human cells that have been engineered to respond to an electrical current could be incorporated into future medical devices.
Source: www.nature.comCategories: Healthcare Professionals, Latest HeadlinesTweet-
Experimental #insulin implant uses #electricity to control #genes https://t.co/6HxmSFIpoH
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Mashup Score: 13
Objective: Multidisciplinary studies of posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) implicate the dorsolateral prefrontal cortex (DLPFC) in disease risk and pathophysiology. Postmortem brain studies have relied on bulk-tissue RNA sequencing (RNA-seq), but single-cell RNA-seq is needed to dissect cell-type-specific mechanisms. The authors conducted the first single-nucleus RNA-seq postmortem brain study in PTSD to elucidate disease transcriptomic pathology with cell-type-specific resolution. Method: Profiling of 32 DLPFC samples from 11 individuals with PTSD, 10 with MDD, and 11 control subjects was conducted (∼415K nuclei; >13K cells per sample). A replication sample included 15 DLPFC samples (∼160K nuclei; >11K cells per sample). Results: Differential gene expression analyses identified significant single-nucleus RNA-seq differentially expressed genes (snDEGs) in excitatory (EX) and inhibitory (IN) neurons and astrocytes, but not in other cell types or bul
Source: ajp.psychiatryonline.orgCategories: General Medicine News, Latest HeadlinesTweet-
#Brain single-cell study reveals #genes that may be involved in post-traumatic stress and major depressive disorders https://t.co/vdVXFgNRUb https://t.co/jdc8uSEtuu
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Mashup Score: 9Researchers identify genes that directly influence what we eat - 9 month(s) ago
In one of the first large-scale studies of genes related to diet, researchers have uncovered almost 500 genes that appear to directly influence the foods we eat. The findings represent an important step …
Source: medicalxpress.comCategories: General Medicine News, Latest HeadlinesTweet-
Researchers identify #genes that directly influence what we eat https://t.co/pKdb1Jim0d
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Mashup Score: 0Mitochondrial MICOS complex genes, implicated in hypoplastic left heart syndrome, maintain cardiac contractility and actomyosin integrity - 9 month(s) ago
Abstract Hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease (CHD) with a likely oligogenic etiology, but our understanding of the genetic complexities and pathogenic mechanisms leading to HLHS is limited. We therefore performed whole genome sequencing (WGS) on a large cohort of HLHS patients and their families to identify candidate genes that were then tested in…
Source: eLifeCategories: General Medicine News, Latest HeadlinesTweet-
New #genes implicated in deadly #heart defect @sbpdiscovery @elife https://t.co/MC3BRcxBSE https://t.co/MPhLAZ2ImL
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Mashup Score: 0Prioritization of genes associated with type 2 diabetes mellitus for functional studies - Nature Reviews Endocrinology - 10 month(s) ago
More genetic variants associated with type 2 diabetes mellitus are being identified. This Perspective article outlines various tools and platforms that can be applied to prioritize candidate genes associated with an increased risk of disease for functional validation.
Source: NatureCategories: Endocrinology, Latest HeadlinesTweet-
In our latest issue, Wei Xuan Tan, Xueling Sim, Chin Meng Khoo & Adrian K. K. Teo discuss prioritization of #genes associated with type 2 #diabetes mellitus for functional studies (£) https://t.co/qMpU3PDpUb #T2DM #T2D https://t.co/fAbD4y00A5
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Researchers argue that long #genes age faster -- and this quirk may play a role in how people age. Read more from this Opinion in @TrendsGenetics: https://t.co/BbkXDw8lS4 @tecnun Ander Izeta, @MolecularGenet3 Jan H.J. Hoeijmakers, @NUFeinbergMed Thomas Stoeger https://t.co/ZP1ChBpZwz