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Mashup Score: 0Mitochondrial MICOS complex genes, implicated in hypoplastic left heart syndrome, maintain cardiac contractility and actomyosin integrity - 9 month(s) ago
Abstract Hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease (CHD) with a likely oligogenic etiology, but our understanding of the genetic complexities and pathogenic mechanisms leading to HLHS is limited. We therefore performed whole genome sequencing (WGS) on a large cohort of HLHS patients and their families to identify candidate genes that were then tested in…
Source: eLifeCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 0Metabolic clogging of mannose triggers dNTP loss and genomic instability in human cancer cells - 9 month(s) ago
Proteomic and metabolomic analyses reveal how mannose exerts its anticancer activity.
Source: eLifeCategories: General Medicine News, Latest HeadlinesTweet-
New study helps explain the anti-#cancer properties of mannose #sugar @sbpdiscovery @elife https://t.co/EDmkSeMOSd https://t.co/0qHHTqIrCr
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Mashup Score: 0
The zebrafish has been established as a genetic and molecular model for the blood-brain barrier.
Source: eLifeCategories: General Medicine News, Latest HeadlinesTweet-
Researchers uncover signal needed for #blood-brainbarrier @harvardmed https://t.co/ZuuhiW7I1D https://t.co/gMsNTN7Wn6
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Mashup Score: 7Repair of noise-induced damage to stereocilia F-actin cores is facilitated by XIRP2 and its novel mechanosensor domain - 10 month(s) ago
A novel mechanism for F-actin repair is involved in the maintenance of sensory hair cells and hearing function.
Source: eLifeCategories: Latest Headlines, NeurologyTweet-
“Repair of noise-induced damage to stereocilia F-actin cores is facilitated by XIRP2 and its novel mechanosensor domain” by Jung-Bum Shin et al. eLife https://t.co/8MxXLtVhw7 2/2 https://t.co/Ol9Zq3hxa5
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Mashup Score: 1Ebola virus disease in the Democratic Republic of the Congo, 1976-2014 - 10 month(s) ago
Analysing a compilation of individual-level data gathered across the seven Ebola Virus Disease outbreaks in the Democratic Republic of the Congo reveals factors that contribute to the spread of the disease and mortality.
Source: eLifeCategories: Infectious Disease, Latest HeadlinesTweet-
Final note: above Ebola data is from: https://t.co/QDO491iTkh – obviously don't upload any sensitive data to code interpreter! 5/5
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Mashup Score: 0Presenting a sham treatment as personalised increases the placebo effect in a randomised controlled trial - 10 month(s) ago
A laboratory experiment provides the first evidence that framing a sham treatment as personalised to one’s genetics and physiology increases its placebo effect on pain.
Source: eLifeCategories: Hem/Oncs, Latest HeadlinesTweet-
Personalised placebo: A new @ellenjl et al study shows that simply believing a sham medical treatment is personalised increases its effectiveness. https://t.co/DKYybWQkTo via @eLifeSciences
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Mashup Score: 13Spatial determination and prognostic impact of the fibroblast transcriptome in pancreatic ductal adenocarcinoma - 10 month(s) ago
Abstract Pancreatic ductal adenocarcinoma has a poor clinical outcome and responses to immunotherapy are suboptimal. Stromal fibroblasts are a dominant but heterogenous population within the tumor microenvironment and therapeutic targeting of stromal subsets may have therapeutic utility. Here we combine spatial transcriptomics and scRNA-Seq datasets to define the transcriptome of…
Source: eLifeCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
RT @Aiims1742: Spatial determination and prognostic impact of the fibroblast transcriptome in #PancreaticCancer https://t.co/QA0NLNz3eD Tu…
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Mashup Score: 0Syncytin-mediated open-ended membrane tubular connections facilitate the intercellular transfer of cargos including Cas9 protein - 10 month(s) ago
A human endogenous fusogen, syncytin, which facilitates placental cell-cell fusion during early embryonic development, mediates the formation of open-ended membrane tubular connections between other cell types that efficiently promotes the intercellular transfer of cytoplasmic cargos including Cas9 protein and organelles.
Source: eLifeCategories: Hem/Oncs, Latest HeadlinesTweet-
Syncytin-mediated open-ended membrane tubular connections facilitate the intercellular transfer of cargos including Cas9 protein https://t.co/LJZJcTM9g2
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Mashup Score: 1Spatial determination and prognostic impact of the fibroblast transcriptome in pancreatic ductal adenocarcinoma - 10 month(s) ago
Abstract Pancreatic ductal adenocarcinoma has a poor clinical outcome and responses to immunotherapy are suboptimal. Stromal fibroblasts are a dominant but heterogenous population within the tumor microenvironment and therapeutic targeting of stromal subsets may have therapeutic utility. Here we combine spatial transcriptomics and scRNA-Seq datasets to define the transcriptome of…
Source: eLifeCategories: Hem/Oncs, Latest HeadlinesTweet-
Spatial determination and prognostic impact of the fibroblast transcriptome in #PancreaticCancer https://t.co/QA0NLNz3eD Tumor proximity determines state: “Tumor proximal” - enriched in myCAFs, wnt ligands “Tumor distant” - enriched in iCAFs, complement, wnt inhibitory signals https://t.co/kKdjANz2cR
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Mashup Score: 0Epidemiological characteristics and prevalence rates of research reproducibility across disciplines: a scoping review of articles published in 2018-2019 - 10 month(s) ago
Abstract Introduction: Reproducibility is a central tenant of research. We aimed to synthesize the literature on reproducibility and describe its epidemiological characteristics, including how reproducibility is defined and assessed. We also aimed to determine and compare estimates for reproducibility across different fields. Methods: We conducted a scoping review to identify…
Source: eLifeCategories: Cardiologists, Latest HeadlinesTweet-
A scoping review 'gives an overview of research that explicitly set out to reproduce previous research. Such reproducibility studies are extremely scarce, definition of successfully reproduced study is ambiguous, and reproducibility rate is overall modest' https://t.co/PjepC5jSah
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New #genes implicated in deadly #heart defect @sbpdiscovery @elife https://t.co/MC3BRcxBSE https://t.co/MPhLAZ2ImL