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Mashup Score: 1DSCAM gene triplication causes excessive GABAergic synapses in the neocortex in Down syndrome mouse models - 1 year(s) ago
Developmental brain disorders are a hallmark of Down syndrome, but what cellular and molecular mechanisms underlie these disorders? This study shows that the excessive number of inhibitory synapses in the neocortex of Down syndrome mouse models is caused by increased levels of Down Syndrome Cell Adhesion Molecule (DSCAM).
Source: journals.plos.orgCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 0
Résumé Texte intégral Références Illustrations Compléments Auteurs 1 UCL Queen Square Institute of Neurology, Member of the ERN EpiCARE, London, UK 2 Chalfont Centre for Epilepsy, Bucks, UK 3 Department of Paediatric Clinical Epileptology and Functional Neurology, University Hospitals of Lyon (HCL), Member of the ERN EpiCARE, Lyon, France 4 Epilepsy Research Program, Epilepsy Unit, San…
Source: www.jle.comCategories: Latest Headlines, NeurologyTweet-
Today is World #DownSyndrome Day! Did you know that...? “Down’s syndrome is caused by trisomy 21, and #epilepsy is seen in approximately 10% of affected individuals.” -@EpiDisorders, https://t.co/5g3jEIzYp5 https://t.co/1zaGpTioIA
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Mashup Score: 6Mechanisms underlying autoimmunity in Down syndrome revealed - 1 year(s) ago
Scientists at the Icahn School of Medicine at Mount Sinai in New York have identified which parts of the immune system go awry and contribute to autoimmune diseases in individuals with Down syndrome. The findings published in the February 22 online issue of Nature.
Source: medicalxpress.comCategories: Allergy-Immunology, Latest HeadlinesTweet-
RT @medical_xpress: Mechanisms underlying #autoimmunity in #Downsyndrome revealed @mountsinainyc @nature @ImmunityCP https://t.co/EynA0lengJ
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Mashup Score: 5Mechanisms underlying autoimmunity in Down syndrome revealed - 1 year(s) ago
Scientists at the Icahn School of Medicine at Mount Sinai in New York have identified which parts of the immune system go awry and contribute to autoimmune diseases in individuals with Down syndrome. The findings published in the February 22 online issue of Nature.
Source: medicalxpress.comCategories: General Medicine News, Latest HeadlinesTweet-
Mechanisms underlying #autoimmunity in #Downsyndrome revealed @mountsinainyc @nature @ImmunityCP https://t.co/EynA0lengJ
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Mashup Score: 7Weight loss may be early predictor of Alzheimer's disease in those with Down syndrome - 1 year(s) ago
Unintentional weight loss in people with Down syndrome may predict the onset of Alzheimer’s disease long before typical cognitive symptoms like memory loss and dementia are apparent.
Source: medicalxpress.comCategories: General Medicine News, Latest HeadlinesTweet-
#Weightloss may be early predictor of Alzheimer's disease in those with #Downsyndrome @UWMadison @IOSPress_STM https://t.co/RcawOtTJSk
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Mashup Score: 0Wolters Kluwer Health - 1 year(s) ago
JavaScript Error JavaScript has been disabled on your browser. You must enable it to continue. Here’s how to enable JavaScript in the following browsers: Internet Explorer From the Tools menu, select Options Click the Content tab Select Enable JavaScript Firefox From the Tools…
Source: lww.comCategories: Latest Headlines, NeurologyTweet-
Via @PNASNews: The pathophysiology behind #Alzheimers symptoms that most people with #DownSyndrome develop differs from that of familial or sporadic versions of the disease: https://t.co/dxjKPDi8xY #neurotwitter @INDUCSF @CUAnschutz @Inserm @harvardmed @AANMember https://t.co/0R7E01aCfu
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Mashup Score: 21Altered spontaneous brain activity in Down syndrome and its relation with cognitive outcome - Scientific Reports - 1 year(s) ago
Although Down syndrome (DS) is the most common genetic cause of neurodevelopmental delay, few neuroimaging studies have explored this population. This investigation aimed to study whole-brain resting-state spontaneous brain activity using fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo) strategies to find differences in spontaneous brain activity among…
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
Researchers identify differences in spontaneous #brain activity in people with #Downsyndrome @UniBarcelona @SciReports https://t.co/lS6VhDqYS9 https://t.co/qowzPFx6CZ
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Mashup Score: 1
A comparative analysis proposes cellular pathologies in genetic diseases such as Down Syndrome that are caused by the presence of an extra chromosome, depend less on which specific chromosome is duplicated and more on the presence of an extra chromosomal copy. The compares proteomic and transcriptomic datasets of individuals with Down Syndrome and cells generated in the laboratory that carry…
Categories: Future of Medicine, Latest HeadlinesTweet-
.@HeidelbergU and @uamshealth conducted a comparative analysis to propose cellular pathologies in genetic diseases such as #DownSyndrome that are caused by the presence of an extra chromosome. Read more: https://t.co/uceKAukF4g https://t.co/1GsFByBC47
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Mashup Score: 0
A comparative analysis proposes cellular pathologies in genetic diseases such as Down Syndrome that are caused by the presence of an extra chromosome, depend less on which specific chromosome is duplicated and more on the presence of an extra chromosomal copy. The compares proteomic and transcriptomic datasets of individuals with Down Syndrome and cells generated in the laboratory that carry…
Categories: Future of Medicine, Latest HeadlinesTweet-
.@HeidelbergU and @uamshealth conducted a comparative analysis to propose cellular pathologies in genetic diseases such as #DownSyndrome that are caused by the presence of an extra chromosome. Read more: https://t.co/uceKAukF4g https://t.co/ozDPuyaedD
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Mashup Score: 4Down syndrome research should look at the whole cell, not just the extra chromosome, scientists say - 1 year(s) ago
Research on understanding the effect of extra chromosomes for conditions like Down syndrome typically involves examining what genes play a role in the symptoms of these conditions. However, researchers from Germany and the U.S. propose a new way of looking at these conditions, suggesting that when an extra chromosome is present, the impact on the cell depends less on which chromosome is…
Source: medicalxpress.comCategories: General Medicine News, Latest HeadlinesTweet-
#Downsyndrome research should look at the whole cell, not just the #extrachromosome, scientists say @AJHGNews https://t.co/vpDtU09zYA
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A gene involved in #Downsyndrome puts the brakes on neurons' activity in mice, new study shows @umich @PLOSBiology https://t.co/VQRhI5WpnL https://t.co/RDUXsYV4DV