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Mashup Score: 6Autocrine vitamin D signaling switches off... - 3 year(s) ago
The molecular mechanisms governing orderly shutdown and retraction of CD4+ type 1 helper T (TH1) cell responses remain poorly understood. Here we show that complement triggers contraction of TH1 responses by inducing intrinsic expression of the vitamin D (VitD) receptor and the VitD-activating enzyme CYP27B1, permitting T cells to both activate and respond to VitD. VitD then initiated the…
Source: www.nature.comCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 4The Role of Properdin in C5 Convertase Activity and C5b-9 Formation in the Complement Alternative Pathway - 3 year(s) ago
This article is featured in Top Reads , p.[][1] [1]: /lookup/volpage/207/2391
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet-
#JI_TopRead: New #complement research by Elena B. Volokhina, Marloes Michels @MarloesMichels, Lambertus P.W.J. van den Heuvel & colleagues @radboudumc @UZLeuven @Nicolevandekar @MarloesMichels| The role of properdin in C5 convertase activity | https://t.co/bS4WFiwZRd #ReadTheJI https://t.co/u0PpOudssd
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Mashup Score: 7Structural basis of soluble membrane attack complex packaging for clearance - Nature Communications - 3 year(s) ago
To prevent unregulated complement activation, extracellular chaperones capture soluble precursors to the membrane attack complex (sMAC). Here, structural analysis of sMAC reveals how clusterin recognizes heterogeneous sMAC complexes and inhibits polymerization of complement protein C9.
Source: Nature CommunicationsCategories: General Medicine News, Latest HeadlinesTweet-
Authors @anaismenny and @Marie_Lukassen from @bubecklab @imperialcollege and collaborators from @hecklab report the structure of the soluble membrane attack complex (sMAC), with insights into the regulation of complement activation. #cryoEM #complement https://t.co/8FNHn6o7DV https://t.co/8VynMhHICH
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Mashup Score: 10
Experimental design, workflow and results. Elevated complement, cytoskeleton and lipid metabolism proteins were identified.
Source: Wiley Online LibraryCategories: Latest Headlines, TransplantationTweet-
Proteomic analysis of #machine #perfusion solution from #DBD #kidneys reveals that elevated #complement, #cytoskeleton and #lipid #metabolism proteins are associated with 1-year #outcome @BenediktKessler https://t.co/l6bRYZYNc5 https://t.co/KwFq8F3aTU
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Mashup Score: 2Off the Beaten Pathway - 3 year(s) ago
Not all pathways lead to success, but selectively blocking a single pathway of the complement cascade may lead to the first approved geographic atrophy therapy
Source: The OphthalmologistCategories: Latest Headlines, OphthalmologyTweet-
“It may be better to use a sniper rifle to target what's really important, instead of using a bazooka to blow the whole thing up” #OphthoTwitter #Ophthalmology #ClinicalTrial #Pharma #GA #AMD #Complement https://t.co/eqZEw152R7
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Mashup Score: 4FEBS Press - 3 year(s) ago
Skip to Article Content Skip to Article Information
Source: FEBS PressCategories: Infectious Disease, Latest HeadlinesTweet-
6/ #Neisseria and #complement deficiency Complement: innate immune defense vs. Neisseria. Congenital and acquired defects in complement increase risk for invasive Neisseria infections (meningococcal disease / disseminated gonococcal infection) https://t.co/bdro2W6zjT
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Mashup Score: 3Off the Beaten Pathway - 3 year(s) ago
Not all pathways lead to success, but selectively blocking a single pathway of the complement cascade may lead to the first approved geographic atrophy therapy
Source: The OphthalmologistCategories: Latest Headlines, OphthalmologyTweet-
Not all pathways lead to success. Peter Kaiser on the clinical trial that may lead to a treatment for geographic atrophy (dry AMD) by blocking a specific immune pathway. #OphthoTwitter #Ophthalmology #ClinicalTrial #Pharma #GA #AMD #Complement https://t.co/eqZEw152R7
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Mashup Score: 6FOCIS 2021 Virtual Annual Meeting - 3 year(s) ago
Tuesday, June 8, 2021 7:00 AM – 10:30 AM US PDT 7:00 am Overview of Complement Pathways and Associations with Human DiseaseViviana Ferreira, DVM, PhD, University of Toledo College of Medicine7:45 am The Complosome and Mitochondrial ActivityClaudia Kemper, PhD, National Heart, Lung and Blood Institute8:30 am Local Complement Activation…
Source: www.eventscribe.netCategories: Latest Headlines, RheumatologyTweet-
Join me and Josh Thurman (@CU_Kidney) as we moderate tomorrow’s @FOCISimmunology session supported by @ComplementSoc and @ACRheum on the new roles of #complement in human disease. Talks by @hskulkarni, Claudia Kemper, Viviana Ferreira, and Claire Harris. https://t.co/67LkaZ8wEO
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Mashup Score: 0FDA Advisors Split on New Drug for Vasculitis - 3 year(s) ago
Concerns raised about study design and off-protocol use of steroids
Source: www.medpagetoday.comCategories: Healthcare Professionals, Latest HeadlinesTweet-
FDA Advisors Split on New Drug for #Vasculitis https://t.co/MmZQpTPgP2 #Rheumatology #rheum #ANCA #AAV #StudyDesign #PM101 #avacopan, an oral small molecule inhibitor of the [#complement] #C5a receptor
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Mashup Score: 1Proprotein Convertase Is the Highest-Level Activator of the Alternative Complement Pathway in the Blood - 3 year(s) ago
This article is featured in Top Reads , p.[1979][1] [1]: /lookup/volpage/206/1979
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet-
#JI_TopRead: From researchers in Budapest | MASP-3 activated by PCSK6 critical first step of the #APpathway linking the #complement and #proprotein convertase systems #FactorD #ReadTheJI #immunology https://t.co/uLqbeMiNzx https://t.co/STMfj1STgB
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RT @AfzaliBehdad: Our paper on #VitaminD #complement and #Tcells in health and disease (https://t.co/Sfa7AzQGI5) kindly highlighted in @Nat…