-
Mashup Score: 25The complement system in age-related macular degeneration: A review of rare genetic variants and implications for personalized treatment - 1 month(s) ago
Age-related macular degeneration (AMD) is a progressive retinal disease and the major cause of irreversible vision loss in the elderly. Numerous studies have found both common and rare genetic variants in the complement pathway to play a role in the pathogenesis …
Source: www.ncbi.nlm.nih.govCategories: General Medicine News, RheumatologyTweet
-
Mashup Score: 8Assessment of epidemiology and outcomes of adult patients with kidney-limited thrombotic microangiopathies. - 2 month(s) ago
Thrombotic microangiopathies (TMA) are usually associated with hematological features (RH-TMA). The epidemiology of TMA limited to kidneys (RL-TMA) is unclear Therefore, patients with TMA and native kidney biopsies were identified during 2009-2022 in 20 French hospitals and results evaluated. RL-TMA was present in 341/757 (45%) patients and associated with lower creatinine levels (median 184 vs 346 μmol/L) than RH-TMA. RL-TMA resulted from virtually all identified causes, more frequently from anti-VEGF treatment and hematological malignancies, but less frequently from shigatoxin-associated hemolytic uremic syndrome (HUS), systemic sclerosis, gemcitabine and bacterial infection, and even less frequently when three or more causes/triggers were combined (RL-TMA: 5%; RH-TMA: 12%).
Source: www.kidney-international.orgCategories: General Medicine News, RheumatologyTweet
-
Mashup Score: 1Inhibition of acute complement responses towards bolus-injected nanoparticles using targeted short-circulating regulatory proteins - PubMed - 5 month(s) ago
Effective inhibition of the complement system is needed to prevent the accelerated clearance of nanomaterials by complement cascade and inflammatory responses. Here we show that a fusion construct consisting of human complement receptor 2 (CR2) (which recognizes nanosurface-deposited complement 3 (C …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, RheumatologyTweet
-
Mashup Score: 5
Atypical hemolytic uremic syndrome (aHUS) is a rare kidney disease caused by dysregulation of the complement alternative pathway. The complement dysregulation specifically leads to damage to the glomerular endothelium. To further understand aHUS pathophysiology, we validated an ex vivo model for measuring complement deposition on both control and patient human glomerular microvascular endothelial cells (GMVECs). Endothelial cells were incubated with human test sera and stained with an anti-C5b-9 antibody to visualize and quantify complement depositions on the cells with immunofluorescence microscopy. First, we showed that zymosan-activated sera resulted in increased endothelial C5b-9 depositions compared to normal human serum (NHS). The levels of C5b-9 depositions were similar between conditionally immortalized (ci)GMVECs and primary control GMVECs. The protocol with ciGMVECs was further validated and we additionally generated ciGMVECs from an aHUS patient. The increased C5b-9 depositi
Source: www.frontiersin.orgCategories: General Medicine News, RheumatologyTweet
-
Mashup Score: 5Defective C3d caused by C3 p.W1034R in inherited atypical hemolytic uremic syndrome - PubMed - 6 month(s) ago
C3 p.W1034R results in an inherited form of aHUS that often presents with recurrent episodes, possibly because of impaired interactions between the C3d and C-terminal domains of factor H. Following comprehensive genomic analysis, functional validation of C3 p.W1034R strengthens the molecular basis f …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, RheumatologyTweet
-
Mashup Score: 3Chronic inflammation, neutrophil activity, and autoreactivity splits long COVID - Nature Communications - 10 month(s) ago
Post-acute sequelae of COVID-19 (PASC) has heterogenous presentation and complex etiology. Here the authors profile peripheral blood of patients with PASC and analyze by machine-learning to identify immune and serology features that allow the stratification of PASC into inflammatory and non-inflammatory types for better diagnosis and therapy-planning.
Source: NatureCategories: Latest Headlines, RheumatologyTweet
-
Mashup Score: 2Complement, complosome, and complotype: A perspective - PubMed - 11 month(s) ago
Recent rapid progress in key technological advances, including the broader accessibility of single-cell “omic” approaches, have allowed immunologists to gain important novel insights into the contributions of individual immune cells in protective immunity and immunopathologies. These insights also t …
Source: PubMedCategories: Latest Headlines, RheumatologyTweet
-
Mashup Score: 4Global-feature of autoimmune glomerulonephritis using proteomic analysis of laser capture microdissected glomeruli - PubMed - 12 month(s) ago
The integrative proteomics analysis of the four GNs diseases provide insights into unique characteristics of GNs diseases and further serve as frameworks for precision medicine diagnosis and provide novel targets for drug development.
Source: PubMedCategories: Latest Headlines, RheumatologyTweet
-
Mashup Score: 1Main Episode, #81: RheumyRounds (Part Two) - The Good, The Bad & The Ugly: Office Visits - 12 month(s) ago
In Part Two of this RheumyRounds episode, Tiffany Westrich-Robertson (axial spondyloarthritis) and Deb Constien (rheumatoid arthritis) are joined by rheumato…
Source: YouTubeCategories: Latest Headlines, RheumatologyTweet-
This is SO important. How we manage our emotional reserve is critical to burnout or worse. Pts deserve our full emotional investment, but this is exhausting. @debconstien, @TiffWRobertson, & I discuss this at the 20:50 mark of this @IFAiArthritis podcast: https://t.co/okCV140GCu https://t.co/h3sqbxhqHF
-
-
Mashup Score: 3Lessons from Master Clinicians: An Interview with Dr. Richard Brasington - The Rheumatologist - 1 year(s) ago
Rheumatologists who are outstanding clinicians and provide consistent, exceptional care to patients are in the spotlight in our Lessons from a Master Clinician series. Here, we present insights from a clinician who has achieved distinction in the field of rheumatology, serving as a role model for colleagues and trainees. You Might Also Like Lessons from… [Read More]
Source: The RheumatologistCategories: Latest Headlines, RheumatologyTweet
This is interesting given that complement plays a major role in macular degeneration, which happens to overlap w/ a few of these autoimmune diseases. We don’t screen for GoF (FB, FD) nor LoF (FH, FI) variants in our pts w/ autoimmune dz. Maybe we should. https://t.co/n6jWuGvEWB https://t.co/1lwBavG8L9