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Mashup Score: 3
The optimal approach towards managing serum potassium and hemodialysate potassium concentrations is uncertain. To study this, adults receiving hemodialysis for three months or more with hyperkalemia (pre-dialysis serum potassium (sK+) 5.1–6.5 mEq/l) had cardiac monitors implanted and were randomized to either eight weeks of 2.0 potassium/2.5 calcium mEq/l dialysate without sodium zirconium cyclosilicate (SZC) (2.0 potassium/noSZC) or 3.0 potassium/2.5 calcium mEq/l dialysate combined with SZC (3.0 potassium/SZC) on non-dialysis days to maintain pre-dialysis sK+ 4.0–5.5 mEq/l, followed by treatment crossover for another eight weeks.
Source: www.kidney-international.orgCategories: General Medicine News, NephrologyTweet
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Mashup Score: 5Hair-straightening cosmetics containing glyoxylic acid induce crystalline nephropathy - 26 day(s) ago
We recently reported the case of a patient who experienced three consecutive episodes of acute kidney injury, all of them following a “Brazilian” hair-straightening treatment. The cream used for the straightening procedure contained glyoxylic acid. To examine possible underlying mechanisms causing kidney injury, four groups of mice were exposed to topical application of (i) the straightening product, (ii) a cream containing 10% glyoxylic acid, (iii) a cream containing 10% glycolic acid or (iv) a control cream.
Source: www.kidney-international.orgCategories: General Medicine News, NephrologyTweet-
One more recent evidence here: https://t.co/iigCt2I1W5
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Mashup Score: 179Lupus Nephritis: Redefining the treatment goals - 2 month(s) ago
The course of proliferative lupus nephritis (LN) is characterized by flares of activity alternating with periods of quiescence, against a background of chronic immune dysregulation. An accurate assessment of disease activity is of unassailable importance to tailor therapy. In the present communication, we discuss the available clinical, serological and histological tools to evaluate disease activity and how they may be applied to redefine the treatment goals in LN. Traditionally, treatment response is judged by the degree of proteinuria reduction and improvement of kidney function, but this fails to differentiate ongoing inflammatory disease from chronic damage.
Source: www.kidney-international.orgCategories: General Medicine News, NephrologyTweet-
Time for a new look at how to manage LN. The old proteinuric centric approach is not enough. In patients with anti-ds-DNA and proliferative LN, targeting immunological remission (negative anti-ds-DNA and normalization of complement) is the key 🔑! https://t.co/QF5K76B6pu
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Mashup Score: 179Lupus Nephritis: Redefining the treatment goals - 2 month(s) ago
The course of proliferative lupus nephritis (LN) is characterized by flares of activity alternating with periods of quiescence, against a background of chronic immune dysregulation. An accurate assessment of disease activity is of unassailable importance to tailor therapy. In the present communication, we discuss the available clinical, serological and histological tools to evaluate disease activity and how they may be applied to redefine the treatment goals in LN. Traditionally, treatment response is judged by the degree of proteinuria reduction and improvement of kidney function, but this fails to differentiate ongoing inflammatory disease from chronic damage.
Source: www.kidney-international.orgCategories: General Medicine News, NephrologyTweet-
Time for a new look at how to manage LN. The old proteinuric centric approach is not enough. In patients with anti-ds-DNA and proliferative LN, targeting immunological remission (negative anti-ds-DNA and normalization of complement) is the key 🔑! https://t.co/QF5K76B6pu
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Mashup Score: 11Diagnosis and Management of Immune Checkpoint Inhibitor-Associated Nephrotoxicity: A Position Statement from the American Society of Onco-nephrology - 2 month(s) ago
Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer and are now the backbone of therapy for several malignancies. However, ICIs can cause a spectrum of renal immune-related adverse events including acute kidney injury (AKI), most commonly manifesting as acute interstitial nephritis (AIN), though glomerular disease and electrolyte disturbances have also been reported. In this position statement by the American Society of Onco-nephrology (ASON), we summarize the incidence and risk factors for ICI-AKI, pathophysiological mechanisms and clinicopathological features of ICI-AKI.
Source: www.kidney-international.orgCategories: General Medicine News, NephrologyTweet-
RT @JasmineNephro: 🫘Immune checkpoint inhibitor AKI approach https://t.co/Mm75cMH09w https://t.co/ASHDzJ73ql
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Mashup Score: 3
The optimal approach towards managing serum potassium and hemodialysate potassium concentrations is uncertain. To study this, adults receiving hemodialysis for three months or more with hyperkalemia (pre-dialysis serum potassium (sK+) 5.1–6.5 mEq/l) had cardiac monitors implanted and were randomized to either eight weeks of 2.0 potassium/2.5 calcium mEq/l dialysate without sodium zirconium cyclosilicate (SZC) (2.0 potassium/noSZC) or 3.0 potassium/2.5 calcium mEq/l dialysate combined with SZC (3.0 potassium/SZC) on non-dialysis days to maintain pre-dialysis sK+ 4.0–5.5 mEq/l, followed by treatment crossover for another eight weeks.
Source: www.kidney-international.orgCategories: General Medicine News, NephrologyTweet-
RT @NephroSeeker: 6/ 🔥and simultaneous publication in @Kidney_Int #KidneyWk https://t.co/eVm1TbLPzk
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Mashup Score: 10
In this pre-specified sub-study of the POISE-3 trial, we examined the effect of a perioperative hypotension-avoidance strategy versus a hypertension-avoidance strategy on the risk of postoperative acute kidney injury (AKI). Altogether,7307 patients were included from 110 hospitals in 22 countries. Patients were 45 years and older, had or were at risk of atherosclerotic disease, took at least one antihypertensive medication, and were scheduled for noncardiac surgery. Hypotension-avoidance strategy: (i) target intraoperative mean arterial pressure (MAP) 80 mm Hg or over, (ii) on day of surgery and for two days after, hold renin-angiotensin-aldosterone system inhibitors and use other antihypertensives in stepwise fashion if systolic blood pressure (SBP) 130 mm Hg or more.
Source: www.kidney-international.orgCategories: General Medicine News, NephrologyTweet-
@fperrywilson @JAMA_current @NatureMedicine @willkidney @NEJM 8th trial @AmitXGarg (of course) with the kidney outcomes from POISE 3 https://t.co/BiIIBr3E3e In @Kidney_Int #KidneyWk 8/
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Mashup Score: 87Diagnosis and Management of Immune Checkpoint Inhibitor-Associated Nephrotoxicity: A Position Statement from the American Society of Onco-nephrology - 2 month(s) ago
Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer and are now the backbone of therapy for several malignancies. However, ICIs can cause a spectrum of renal immune-related adverse events including acute kidney injury (AKI), most commonly manifesting as acute interstitial nephritis (AIN), though glomerular disease and electrolyte disturbances have also been reported. In this position statement by the American Society of Onco-nephrology (ASON), we summarize the incidence and risk factors for ICI-AKI, pathophysiological mechanisms and clinicopathological features of ICI-AKI.
Source: www.kidney-international.orgCategories: General Medicine News, NephrologyTweet-
Just out @Kidney_Int https://t.co/mEyvFw9bU2 Diagnosis and Management of Immune Checkpoint Inhibitor-Associated Nephrotoxicity: A Position Statement from the American Society of Onco-nephrology @onconephsociety @onconeph @HerrmannMd @renalmyeloma @ShrutiGkidney @ArashRashidi14
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Mashup Score: 4Looking into the cholesterol crystal ball: is complement the answer? - 2 month(s) ago
Cholesterol crystal embolism (CCE) is a complication of atherosclerosis and can cause microvascular obstruction in multiple organs. Because the consequences may be fatal, and there is no specific treatment, it is crucial to understand the mechanisms and identify treatment strategies. In this issue, Zhao et al., using a mouse model of kidney CCE, demonstrated that inhibition of C5a/C5aR prevented and resolved CCE-induced renal thrombosis and angiopathy. Although these findings must be extended to human condition, they offer hope for management of CCE syndrome.
Source: www.kidney-international.orgCategories: General Medicine News, NephrologyTweet-
RT @ChangUCanSpare: If you haven't figured it out yet, complement will always be at least part of the answer https://t.co/E5NG8r1xLI
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Mashup Score: 10Interference of urinary albumin-to-creatinine ratio measurement by glycosuria: clinical implications when using SGLT-2 inhibitors - 3 month(s) ago
Urinary albumin-to-creatinine ratio (uACR) measured on spot samples provides a convenient method to screen for, diagnose, stage, and monitor chronic kidney disease (CKD),1 and change in albuminuria is proposed as a surrogate outcome for CKD progression in clinical trials.2 Sodium glucose cotransporter-2 (SGLT-2) inhibitors are increasingly used because of important effects on risk of cardiovascular disease and CKD progression.3 Under normoglycemic and modest hyperglycemic conditions, SGLT-2 inhibitors increase urinary glucose excretion to ∼50–80 g/d, and to >100 g/d in people with diabetes and glomerular hyperfiltration.
Source: www.kidney-international.orgCategories: General Medicine News, NephrologyTweet-
@GlassockJ @SabineKaram6 @M_Elraggal @KIReports @CKJsocial This is the data Prof G is alluding to From https://t.co/0lSR1mIhWt - not about efficacy, but the use of albuminuria as a surrogate outcome while Flozinating Pushback: - can be overcome by using Enzymatic, not Jaffe assay - only clinically relevant when terribly high BS? https://t.co/CV8lpQyhqH
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RT @NephroSeeker: 6/ 🔥and simultaneous publication in @Kidney_Int #KidneyWk https://t.co/eVm1TbLPzk