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Mashup Score: 3Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity - Nature Communications - 2 year(s) ago
The L protein of segmented, negative strand RNA viruses contains the RNA-dependent RNA polymerase essential for virus amplification. Here, the authors report cryoEM structures of the Lassa virus L protein in active, RNA-bound states, and provide mechanistic insights.
Source: Nature CommunicationsCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 2Proximal and distal effects of genetic susceptibility to multiple sclerosis on the T cell epigenome - Nature Communications - 2 year(s) ago
Integrating functional data with GWAS loci can help interpret the function of genetic variants associated with disease. Here the authors map cis and trans methylation QTL in CD4 + T cells from patients and colocalize with GWAS loci in order to interpret genetic variants associated with multiple sclerosis.
Source: Nature CommunicationsCategories: Latest Headlines, NeurologyTweet-
Proximal and distal effects of genetic susceptibility to multiple sclerosis on the T cell epigenome https://t.co/CxMpgpN6A5
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Mashup Score: 0A viral genome packaging ring-ATPase is a flexibly coordinated pentamer - Nature Communications - 2 year(s) ago
In viruses, multi-subunit ring-ATPases are involved in genome packaging. Here, using single-molecule techniques, the authors determine that the active bacteriophage T4 DNA packaging motor is a pentamer and show that the motor can tolerate inactive subunits, suggesting that strict coordination between the subunits is not crucial.
Source: Nature CommunicationsCategories: General Medicine News, Latest HeadlinesTweet-
Authors @dgvjayS, @taekjip, @RaoBPhageMRC and others use single-molecule techniques to assess the mechanism of the bacteriophage T4 DNA packaging motor . https://t.co/5hIuQGnqBg https://t.co/Z6f7B1Tthe
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Mashup Score: 2WFS1 functions in ER export of vesicular cargo proteins in pancreatic β-cells - Nature Communications - 2 year(s) ago
The role of cargo receptors in proinsulin export from the ER is unclear. Here, the authors identify the WFS1 protein, which is mutated in Wolfram syndrome and associated with diabetes, as an ER to Golgi cargo receptor required for normal insulin processing and secretion.
Source: Nature CommunicationsCategories: General Medicine News, Latest HeadlinesTweet-
An ER to Golgi cargo receptor mutated in Wolfram syndrome is important for proinsulin processing and insulin secretion https://t.co/XDMyNK2bfO
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Mashup Score: 9Widespread homogenization of plant communities in the Anthropocene - Nature Communications - 2 year(s) ago
Human-driven movements and extinctions of species have made plant communities across biomes more homogenous. Here the authors quantify plant vascular species and phylogenetic homogenization across the globe, finding that non-native species naturalisations have been a major driver.
Source: Nature CommunicationsCategories: General Medicine News, Latest HeadlinesTweet-
Study quantifies plant vascular species and phylogenetic homogenization across the globe, finding that non-native species naturalisations have been a major driver https://t.co/xQMNaPfSuP @Barnabas_Daru @Kowiyou1 @bugEcology @Klaus_Schlip @betsyarizona @ea_bowman @BenDW @ggiribet
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Mashup Score: 4A plant virus satellite RNA directly accelerates wing formation in its insect vector for spread - Nature Communications - 2 year(s) ago
The cucumber mosaic virus is accompanied by short RNA molecules, satellite RNAs. This study shows that leaves infected with Y-satellite RNA preferentially attract aphids and manipulate aphid physiology to promote their spread to neighbouring plants.
Source: Nature CommunicationsCategories: General Medicine News, Latest HeadlinesTweet-
The cucumber mosaic virus is accompanied by short, satellite RNAs. This study shows that leaves infected with Y-satellite RNA preferentially attract aphids and manipulate aphid physiology to promote their spread to neighbouring plants. Find out more here: https://t.co/jRtL5kA1mH
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Mashup Score: 9
Glucocorticoids and glucocorticoid receptor (GR) signalling can suppress anti-tumour immunity. Here the authors show that GR activates PD-L1 expression and represses MHC-I expression in pancreatic cancer cells, while GR inhibition enhances anti-tumour immunity and sensitises the cancer cells to immunotherapy.
Source: Nature CommunicationsCategories: Hem/Oncs, Latest HeadlinesTweet-
From Dr. Li Ma et al @MDAndersonNews in @NatureComms: Glucocorticoid receptor regulates PD-L1 and MHC-I in #PancreaticCancer cells to promote immune evasion and #immunotherapy resistance https://t.co/BVDRyOUdhH https://t.co/XFN45yiTpx
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Mashup Score: 0A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division - Nature Communications - 2 year(s) ago
PKCε is known to exert a role in genome protection by directly phosphorylating and switching the specificity of Aurora B. Here the authors identify SERBP1 as a parallel mitotic PKCε substrate controlling translation and ensuring the integrity of chromosome segregation and successful cell division.
Source: Nature CommunicationsCategories: General Medicine News, Latest HeadlinesTweet-
SERBP1 is a parallel mitotic PKCε substrate @Drsilviamartini @CRUKKHP @TheCrick https://t.co/7DuezjJZrI
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Mashup Score: 4The histologic phenotype of lung cancers is associated with transcriptomic features rather than genomic characteristics - Nature Communications - 2 year(s) ago
The molecular determinants of lung cancer histologic subtypes are not well understood. Here the authors analyze lung cancers of mixed histology and find that histologic subtypes are associated with transcriptomic features rather than genomic profiles in most tumors.
Source: Nature CommunicationsCategories: General Medicine News, Latest HeadlinesTweet-
Analysis of rare #LungCancer cases with mixed histology indicates that histologic #subtypes are associated with #transcriptomic rather than #genomic features #CancerResearch by @tangming2005 @HusseinAbbas01 and colleagues https://t.co/vcXsE96DYM https://t.co/6roB6pGYqS
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Mashup Score: 1Cilia locally synthesize proteins to sustain their ultrastructure and functions - Nature Communications - 2 year(s) ago
Cilia are microtubule-based organelles containing proteins transported from the cell body. Here, the authors show that the multicilia of mouse ependymal cells contain ribosomal components, tubulin mRNA,18 S rRNA and nascent tubulin peptides, suggesting local translation in the ciliary compartment.
Source: Nature CommunicationsCategories: General Medicine News, Latest HeadlinesTweet-
Mouse ependymal cilia locally translate proteins https://t.co/X0Jqtxo3jD https://t.co/Kog9XVT1YY
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Researchers @tm_kouba, @MariaR0senthal and others from @EMBLGrenoble, @LeibnizHPI, @CssbHamburg, @unihh and @BNITM_de report cryoEM structures of the Lassa virus L protein in active, RNA-bound states. #LoveVirology #CryoEM #bunyaviruses #emergingviruses https://t.co/Xkt688onh8 https://t.co/y2F9Ti0tsL