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Mashup Score: 0A geometric criterion for the optimal spreading of active polymers in porous media - Nature Communications - 2 year(s) ago
Navigation through porous environments poses a major challenge for swimming microorganisms and future microrobots. This study predicts that their spreading becomes optimal when their run length is comparable to the longest available pore length.
Source: Nature CommunicationsCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 2The SARS-CoV-2 spike protein is vulnerable to moderate electric fields - Nature Communications - 2 year(s) ago
The SARS-CoV-2 Spike protein is essential for viral infectivity and binds to the host receptor ACE2. Here, the authors present MD simulations of the Spike protein and its variants of concern and observe that the Spike protein is destabilised by moderate static electric fields, and undergoes field-induced conformational changes that hinder binding to ACE2.
Source: Nature CommunicationsCategories: Expert Picks, Latest HeadlinesTweet-
The SARS-CoV-2 spike protein is vulnerable to moderate electric fields | Nature Communications https://t.co/mSGatYXNN5
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Mashup Score: 1Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers - Nature Communications - 2 year(s) ago
In the classic two-hit model, both alleles of a tumour suppressor gene need to be inactivated in order to promote cancer. Here, the authors challenge this model, finding that many cancer genes can be either one-hit or two-hit drivers depending on the context and other mutations in a tumor.
Source: Nature CommunicationsCategories: Latest Headlines, Oncologists1Tweet-
Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers https://t.co/WW62YZnGBd
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Mashup Score: 8
Information-seeking is important for learning, social behaviour and decision making. Here the authors investigate factors that associate with individual differences in information-seeking behaviour.
Source: Nature CommunicationsCategories: Latest Headlines, NeurologyTweet-
“Whether people inform themselves or remain ignorant is due to three factors” by Christopher. A. Kelly & Tali Sharot. Nature Communication https://t.co/bsgZBWoP1D
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Mashup Score: 16ATR inhibition enables complete tumour regression in ALK-driven NB mouse models - Nature Communications - 2 year(s) ago
Effective therapeutic options are still needed in neuroblastoma treatment. Here, the authors, through a comprehensive proteomics analysis, identify ATR as a potential therapeutic target of neuroblastoma and demonstrate the efficacy of the ATR inhibitor BAY1895344 in combination with the ALK tyrosine kinase inhibitor lorlatinib.
Source: Nature CommunicationsCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Combined ATR and ALK inhibition enables complete tumour regression in multiple mouse models of ALK-driven neuroblastoma; this strategy exploits increased oncogene-induced replication stress in the cancer cells: https://t.co/DHrSNubZ5a #pedcsm #caxtx
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Mashup Score: 1Water sources aggregate parasites with increasing effects in more arid conditions - Nature Communications - 2 year(s) ago
Amid climate and land use changes, it is important to identify and monitor hotspots of animal activity where disease transmission can occur. Using experimental and observational methods in an East African savannah, this study shows water sources increase the concentration of faecal-oral parasites in the environment and that this effect is amplified in drier areas and following periods of low…
Source: Nature CommunicationsCategories: General Medicine News, Latest HeadlinesTweet-
Working in an East African savannah, @gtitcomb et al show water sources increase fecal-oral #parasites in the environment & this is amplified in drier areas & following low rainfall https://t.co/mIPVOEJxDp @EEMBUCSB #MpalaResearchCentre #OlPejetaConservancy #WilldifeConservation
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Mashup Score: 4A general strategy for C(sp3)–H functionalization with nucleophiles using methyl radical as a hydrogen atom abstractor - Nature Communications - 2 year(s) ago
When carbon-based units are functionalized in photoredox catalysis, electrophilic coupling partners are often used, such that the polarities of the two fragments are appropriately matched. Here the authors show a generalized methodology to instead use nucleophilic coupling partners, which are cheaper and often simpler, via successive hydrogen atom transfer and oxidative radical-polar crossover.
Source: Nature CommunicationsCategories: General Medicine News, Latest HeadlinesTweet-
Check out this paper from the Doyle lab (@princetonchem @uclachem; I. N.-M. Leibler, @MTekleSmith, and A. G. Doyle) on functionalizing abundant C(sp3)–H bonds with easy-to-access nucleophilic coupling partners. https://t.co/WsqElC9tok https://t.co/cbL1ZnD4TA
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Mashup Score: 9Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers - Nature Communications - 2 year(s) ago
In the classic two-hit model, both alleles of a tumour suppressor gene need to be inactivated in order to promote cancer. Here, the authors challenge this model, finding that many cancer genes can be either one-hit or two-hit drivers depending on the context and other mutations in a tumor.
Source: Nature CommunicationsCategories: General Medicine News, Latest HeadlinesTweet-
#CancerResearch by @SolipPark1 @FranSupek @BenLehner shows that many genes can be one-hit or two-hit cancer #drivers depending on the other mutations in the tumour and genetic #interactions @NatResCancer @CNIOStopCancer @IRBBarcelona @CRGenomica https://t.co/HjmEHmBlP5 https://t.co/IHNNQG3Fkm
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Mashup Score: 10Gut microbiome drives individual memory variation in bumblebees - Nature Communications - 2 year(s) ago
Whether gut microbes drive cognitive differences in natural populations of animals remains unknown. Here, Li et al. demonstrate a causal link between increased symbiotic Lactobacillus Firm-5 species (L. apis) and improved long-term memory in bumblebees.
Source: Nature CommunicationsCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
Lactobacillus apis, a specific type of gut bacteria found in bees, is linked to enhanced memory in bumblebees, according to a paper published in @NatureComms. https://t.co/ncT4Hx9uYb https://t.co/6sPYE4ME0g
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Mashup Score: 0Mapping the serum proteome to neurological diseases using whole genome sequencing - Nature Communications - 2 year(s) ago
Serum proteins are easily accessible biomarkers and drug targets. Here, the authors use whole genome sequencing data to describe the genetic architecture of neurologically-relevant serum proteins and establish causal protein-neurological disease relationships.
Source: Nature CommunicationsCategories: General Medicine News, Latest HeadlinesTweet-
Serum proteins are easily accessible biomarkers & drug targets. Here, the authors use whole genome sequencing data to describe the genetic architecture of neurologically-relevant serum proteins & establish causal protein-neurological disease relationships https://t.co/de4sYMXLKO
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Navigation through porous environments poses big challenges for swimming #microorganisms and #microrobots. @c_kurzthaler, @suvendu__mandal & colleagues discuss how to predict optimal spreading based on run and pore lengths. #GettingApplied #ActiveTransport https://t.co/yUhBgL6Llh