-
Mashup Score: 11Epigenomic mapping reveals distinct B cell acute lymphoblastic leukemia chromatin architectures and regulators - 6 month(s) ago
B cell lineage acute lymphoblastic leukemia (B-ALL) is composed of diverse molecular subtypes, and while transcriptional and DNA methylation profiling…
Source: www.sciencedirect.comCategories: General Medicine News, General HCPsTweet
-
Mashup Score: 3Epigenetic modifications driving ground state pluripotency exit require an NF-κB-independent chromatin IκBα function - 9 month(s) ago
Inflammatory signals are key in development and cell differentiation but their orchestration with pluripotency and stemness signals is poorly understood. Our previous work identified a chromatin function of IκBα, the NF-κB inhibitor, that is crucial for differentiation in different types of somatic stem cells. Here we demonstrate that deficiency of IκBα imposes a profound chromatin rewiring defect that impacts on DNA methylation, histone post-translational modifications and transcriptional regulation, stabilizing mouse embryonic stem cells (ESCs) in a ground state of pluripotency while preventing them from pluripotency exit and differentiation. By engineering separation-of-function mutants of IκBα with specific binding to either NF-κB or histones, we demonstrate that regulation of pluripotency state by IκBα is independent of NF-κB but requires the chromatin-related IκBα function. ### Competing Interest Statement patent on IkBa SOF mutants
Source: www.biorxiv.orgCategories: Future of Medicine, Latest HeadlinesTweet-
Glad to help in @biorxivpreprint article by @BigSpinLab @CarrerasIJC @hospitaldelmar about how IκBα defect induces #chromatin rewiring by DNA #methylation and #histone modifications, preventing #embryonic stem cells #pluripotency exit and #differentiation https://t.co/nWRfVdbk04 https://t.co/vbTWZhCzaV
-
-
Mashup Score: 0Chromosome-level organization of the regulatory genome in the Drosophila nervous system - 9 month(s) ago
Topologically associating domains that are megabases apart form meta-domains in mature fly neurons to regulate neuronal gene transcription.
Source: www.cell.comCategories: Healthcare Professionals, Latest HeadlinesTweet
-
Mashup Score: 0Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution - 1 year(s) ago
Human brain development is underpinned by cellular and molecular reconfigurations continuing into the third decade of life. To reveal cell dynamics or…
Source: www.sciencedirect.comCategories: Healthcare Professionals, Latest HeadlinesTweet-
RESOURCE: Human #PrefrontalCortex #gene regulatory dynamics from gestation to adulthood at #singlecell resolution: https://t.co/pN4JgQbLL6 @CellCellPress #PFC #GeneExpression #Chromatin #TranscriptionFactor #BrainDisease #organoid A single-nucleus resolution #transcriptome… https://t.co/l4jdupBHsG https://t.co/BtOOrJGAIb
-
-
Mashup Score: 3C. David Allis (1951–2023) - 1 year(s) ago
Biologist who revolutionized the chromatin and gene-expression field.
Source: www.nature.comCategories: Cardiologists, Latest HeadlinesTweet-
A most unusual personality and sheer genius, so saddened by his early departure- RIP C. David Allis: https://t.co/s8vKwwCblj
-
-
Mashup Score: 0Deciphering the multi-scale, quantitative cis-regulatory code - 1 year(s) ago
The cis-regulatory code dictates how DNA sequence controls quantitative transcription levels of each gene depending on cellular context. Kim and Wysocka review progress and challenges in understanding the layers of this code, from transcription factor binding to cofactor recruitment and ultimately cis-regulatory element specificity and function within complex regulatory landscapes.
Source: Molecular CellCategories: Healthcare Professionals, Latest HeadlinesTweet
-
Mashup Score: 3Chromatin Pioneers | Center for Cancer Research - 1 year(s) ago
For much of the 20th century, scientists were fascinated by DNA. They probed its roles in gene activity and genetic inheritance using genetics, biochemistry and molecular biology. Most of these studies were conducted with DNA in its iconic double-helix formation. Meanwhile, it was well known that DNA in intact cells exists in a much more complex form known as chromatin, with many proteins…
Source: ccr.cancer.govCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
-
Mashup Score: 2H2A.Z deposition by SWR1C involves multiple ATP-dependent steps - Nature Communications - 1 year(s) ago
The multi-subunit SWR1C remodeler deposits histone variant H2A.Z at nucleosomes flanking protein-coding genes. Here the authors use single-molecule and ensemble methodologies to identify three ATP-dependent phases in the H2A.Z deposition reaction.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet
-
Mashup Score: 2IκBα controls dormancy induction in Hematopoietic stem cell development via retinoic acid - 1 year(s) ago
Recent findings are challenging the classical hematopoietic model in which long-term hematopoietic stem cells (LT-HSC) are the base of the hematopoietic system. Clonal dynamics analysis of the hematopoietic system indicate that LT-HSC are not the main contributors of normal hemapoiesis in physiological conditions and the hematopoietic system is mainly maintained by multipotent progenitors (MPPs,…
Source: bioRxivCategories: Future of Medicine, Latest HeadlinesTweet
-
Mashup Score: 2Dominant role of DNA methylation over H3K9me3 for IAP silencing in endoderm - Nature Communications - 2 year(s) ago
Silencing of endogenous retroviruses is crucial for maintaining transcriptional and genomic integrity of cells and is maintained by histone H3K9 methylation and/or DNA methylation in various cell types. Here the authors show that loss of DNA methyltransferase DNMT1 in endoderm results in ERV derepression while H3K9me3 is unaltered.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet
Robust #chromatin map explains heterogeneity of pediatric acute lymphoblastic leukemia @cellpressnews https://t.co/KYAFEhCUWx https://t.co/IriWSjxTox