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Mashup Score: 10
Objectives Systemic lupus erythematosus (SLE) is characterised by systemic inflammation involving various immune cell types. Monocytes, pivotal in promoting and regulating inflammation in SLE, differentiate from classic monocytes into intermediate and non-classic monocytes, assuming diverse roles and changing their proportions in inflammation. In this study, we investigated the epigenetic and transcriptomic profiles of these and novel monocyte subsets in SLE in relation to activity and progression. Methods We obtained the DNA methylomes and transcriptomes of classic, intermediate, non-classic monocytes in patients with SLE (at first and follow-up visits) and healthy donors. We integrated these data with single-cell transcriptomics of SLE and healthy donors and interrogated their relationships with activity and progression. Results In addition to shared DNA methylation and transcriptomic alterations associated with a strong interferon signature, we identified monocyte subset-specific al
Source: ard.bmj.comCategories: General Medicine News, Future of MedicineTweet
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Mashup Score: 13Updates in the Genetics and Epigenetics of Hematological Malignancies: From Knowledge to Applications - 9 day(s) ago
Updates in the Genetics and Epigenetics of Hematological Malignancies: From Knowledge to Applications
Source: www.carrerasresearch.orgCategories: General Medicine News, Future of MedicineTweet
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Mashup Score: 10Solidaris - Una societat de centenàries - 3Cat - 10 day(s) ago
A Catalunya hi ha més de dues mil dones centenàries. Els homes que arriben a aquesta edat son poc més de 400, segons dades de l’IDESCAT. Per saber quina és la realitat demogràfica de la societat catalana entrevistarem Iñaki Permanyer, doctor en Demografia, investigador de l’ICREA al Centre d’Estudis Demogràfics. I el doctor Marco Inzitari, director operatiu per a la Transformació de l’Atenció Intermèdia del Departament de Salut. També parlarem amb l’investigador Manel Esteller, que ha publicat “El secret de la vida eterna” amb el doctor Salvador Macip a Rosa dels Vents. I coneixerem les històries de la Maria Roset, de 102 anys, i la Dolors Compte, que n’acaba de complir 101.
Source: www.ccma.catCategories: General Medicine News, Future of MedicineTweet
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Mashup Score: 19Viure més i millor: què són els ageotipus i com poden ajudar-nos a frenar l'envelliment - 12 day(s) ago
Cada òrgan i cada teixit té un ritme d’envelliment propi que depèn, d’una banda, de la nostra genètica i, de l’altra, de l’entorn i els hàbits de vida
Source: www.ccma.catCategories: General Medicine News, Future of MedicineTweet
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Mashup Score: 31Validate User - 25 day(s) ago
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Source: ashpublications.orgCategories: General Medicine News, Future of MedicineTweet
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Mashup Score: 118Encuentran las claves para la eficacia de los fármacos que modifican el genoma en cánceres - 1 month(s) ago
Barcelona, 14 mar (EFE).- Un pionero estudio liderado por un investigador catalán ha encontrado las claves de la eficacia de los fármacos que se usan para tratar enfermed…
Source: www.lavanguardia.comCategories: General Medicine News, Future of MedicineTweet
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Mashup Score: 16Single-Cell Multiomics Analysis of Myelodysplastic Syndromes and Clinical Response to Hypomethylating Therapy | Mission Bio - 2 month(s) ago
Thank you! Your submission has been received! Oops! Something went wrong while submitting the form. Alterations in epigenetic marks, such as DNA methylation, represent a hallmark of cancer that has been successfully exploited for therapy in myeloid malignancies. Hypomethylating agents (HMAs), such as azacitidine (AZA), have become standard-of-care therapy to treat myelodysplastic syndromes (MDS), a myeloid neoplasms that can evolve into acute myeloid leukemia (AML). However, our capacity to identify who
Source: missionbio.comCategories: General Medicine News, Future of MedicineTweet
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Mashup Score: 30
Affiliations Cancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), Barcelona, Catalonia, Spain Department of Biosciences, Faculty of Science, Technolo gy and Engineering, University of Vic – Central University of Catalonia (UVic-UCC), Vic, Barcelona, Catalonia, Spain Centro de Investigacion Biomedica en Red Cancer (CIBERONC), Madrid, Spain Affiliations Cancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), Barcelona, Catalonia, Spain Affiliations Cancer
Source: journal.chestnet.orgCategories: General Medicine News, Future of MedicineTweet
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Mashup Score: 10Disease activity drives divergent epigenetic and transcriptomic reprogramming of monocyte subpopulations in systemic lupus erythematosus - 2 month(s) ago
Objectives Systemic lupus erythematosus (SLE) is characterised by systemic inflammation involving various immune cell types. Monocytes, pivotal in promoting and regulating inflammation in SLE, differentiate from classic monocytes into intermediate and non-classic monocytes, assuming diverse roles and changing their proportions in inflammation. In this study, we investigated the epigenetic and transcriptomic profiles of these and novel monocyte subsets in SLE in relation to activity and progression. Methods We obtained the DNA methylomes and transcriptomes of classic, intermediate, non-classic monocytes in patients with SLE (at first and follow-up visits) and healthy donors. We integrated these data with single-cell transcriptomics of SLE and healthy donors and interrogated their relationships with activity and progression. Results In addition to shared DNA methylation and transcriptomic alterations associated with a strong interferon signature, we identified monocyte subset-specific al
Source: ard.bmj.comCategories: General Medicine News, Future of MedicineTweet
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Mashup Score: 12Una nueva estrategia para curar enfermedades en un día y para siempre: el silenciamiento epigenético - 2 month(s) ago
Un tratamiento experimental logra inactivar un gen del colesterol malo de forma perdurable en ratones, sin modificar su ADN
Source: elpais.comCategories: General Medicine News, Future of MedicineTweet
Glad to participate in excellent work of @eballestar lab at @CarrerasIJC just published in @ARD_BMJ @EULAR_ORG showing #epigenetic reprogramming of #monocytes in systemic #lupus erythematosus #SLE, an #autoimmune disorder https://t.co/iS75c5C6aH https://t.co/MeYitlxzDt