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Mashup Score: 2Animal Behavior and Cognition | bioRxiv - 17 hour(s) ago
bioRxiv – the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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Mashup Score: 1Bioengineering | bioRxiv - 17 hour(s) ago
bioRxiv – the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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Mashup Score: 3Neuroscience | bioRxiv - 17 hour(s) ago
bioRxiv – the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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Mashup Score: 2Evolutionary Biology | bioRxiv - 17 hour(s) ago
bioRxiv – the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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Mashup Score: 2Animal Behavior and Cognition | bioRxiv - 2 day(s) ago
bioRxiv – the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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Mashup Score: 4Ecology | bioRxiv - 2 day(s) ago
bioRxiv – the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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Mashup Score: 0Bioinformatics | bioRxiv - 2 day(s) ago
bioRxiv – the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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Mashup Score: 1Pharmacology and Toxicology | bioRxiv - 2 day(s) ago
bioRxiv – the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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Mashup Score: 2Microbiology | bioRxiv - 2 day(s) ago
bioRxiv – the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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Mashup Score: 2High-density sampling reveals volume growth in human tumours - 2 day(s) ago
In growing cell populations such as cancer, mutations can serve as markers that allow tracking the past evolution from current samples. The genomic analysis of bulk samples and samples from multiple regions have shed light on the evolutionary forces acting on tumours. However, little is known empirically on the spatio-temporal dynamics of tumour evolution. Here, we leverage published data from resected hepatocellular carcinomas, each with several hundred samples taken in two and three dimensions. Using spatial metrics of evolution, we find that tumour cells grow predominantly uniformly within the tumour volume instead of at the surface. We determine how mutations and cells are dispersed throughout the tumour and how cell death contributes to the overall tumour growth. Our methods shed light on the early evolution of tumours in vivo and can be applied to high-resolution data in the emerging field of spatial biology. ### Competing Interest Statement The authors have declared no competing
Source: www.biorxiv.orgCategories: General Medicine News, Oncologists1Tweet
New papers posted on August 17, 2024: 1 in animal behavior and cognition: https://t.co/7tQS0oPK0z 5 in biochemistry: https://t.co/4CFfZtfFY0 2 in bioengineering: https://t.co/kBN3UQ7DR4 11 in bioinformatics: https://t.co/dNiMwyEYbJ 7 in biophysics: https://t.co/WExV4x2xPK