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Mashup Score: 2m6A-driven SF3B1 translation control steers splicing to direct genome integrity and leukemogenesis - 1 year(s) ago
Cieśla et al. delineate an N6-methyladenosine (m6A)-dependent translational circuitry directing wild-type SF3B1 synthesis and ensuing splicing of DNA repair and epigenetic factors upon oncogenic stress. SF3B1 translation control counteracts genotoxic stress in malignant hematopoietic precursor cells, highlighting a conserved role for m6A/SF3B1-driven splicing regulation in myelodysplastic…
Source: Molecular CellCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 10Stress granules are shock absorbers that prevent excessive innate immune responses to dsRNA - 1 year(s) ago
Paget et al. report that stress granules, condensates that form on cellular stresses, are involved in antiviral innate immunity. Stress granules prevent excessive innate immune activation to protect cells from immune-mediated cell death in viral infections and auto-immunopathology diseases. This suggests a function for SGs to maintain cellular homeostasis.
Source: Molecular CellCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @MolecularCell: Stress granules are shock absorbers that prevent excessive innate immune responses to dsRNA https://t.co/w69Rl8NQDl
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Mashup Score: 0Metabolic sensing and control in mitochondria - 1 year(s) ago
Mitochondria engage both feedback and feedforward control circuits to achieve the robust regulation of metabolism. A diverse array of molecular sensors monitors metabolite levels and fine-tunes enzymatic activities, ensuring swift adaptation to metabolic demand and effective protection against stress.
Source: Molecular CellCategories: Hem/Oncs, Latest HeadlinesTweet-
Metabolic sensing and control in mitochondria https://t.co/NNI1BBfRga
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Mashup Score: 4Combining targeted DNA repair inhibition and immune-oncology approaches for enhanced tumor control - 1 year(s) ago
This review discusses the mechanisms of DNA-damage response inhibition (DDRi) and how these therapies are leveraged to potentiate immunotherapy in cancer. Additionally, we review clinically relevant biomarkers for DDRi efficacy and promising new immunotherapy approaches that can be combined with DDRis to potentially heighten antitumoral effect.
Source: Molecular CellCategories: Latest Headlines, Oncologists1Tweet-
RT @weldeiry: Combining targeted DNA repair inhibition and immune-oncology approaches for enhanced tumor control https://t.co/3im6G3qNUR
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Mashup Score: 0Combining targeted DNA repair inhibition and immune-oncology approaches for enhanced tumor control - 1 year(s) ago
This review discusses the mechanisms of DNA-damage response inhibition (DDRi) and how these therapies are leveraged to potentiate immunotherapy in cancer. Additionally, we review clinically relevant biomarkers for DDRi efficacy and promising new immunotherapy approaches that can be combined with DDRis to potentially heighten antitumoral effect.
Source: Molecular CellCategories: Hem/Oncs, Latest HeadlinesTweet-
Combining targeted DNA repair inhibition and immune-oncology approaches for enhanced tumor control https://t.co/3im6G3qNUR
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Mashup Score: 0Deciphering the multi-scale, quantitative cis-regulatory code - 1 year(s) ago
The cis-regulatory code dictates how DNA sequence controls quantitative transcription levels of each gene depending on cellular context. Kim and Wysocka review progress and challenges in understanding the layers of this code, from transcription factor binding to cofactor recruitment and ultimately cis-regulatory element specificity and function within complex regulatory landscapes.
Source: Molecular CellCategories: Healthcare Professionals, Latest HeadlinesTweet-
Deciphering the multi-scale, quantitative cis-regulatory code https://t.co/nSRcnUzqWd #trancscription #enhancers #chromatin #nuclearorganization #generegulation FOUR LAYERS OF THE CIS- REGULATORY CODE: https://t.co/mwKaFwqgm6
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Mashup Score: 2SMARCA4 vulnerability in H3K27M midline glioma: A silver bullet for a lethal disease - 1 year(s) ago
To investigate epigenetic dependencies and identify therapeutic vulnerabilities, Mo et al.1 and Panditharatna et al.2 performed CRISPR screens and show that deadly H3K27M gliomas are dependent on mammalian BAF (SWI/SNF) chromatin remodeling complex.
Source: Molecular CellCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @MolecularCell: SMARCA4 vulnerability in H3K27M midline glioma: A silver bullet for a lethal disease https://t.co/tO9Cj1aBEW
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Mashup Score: 26
Ghosh et al. report that the tumor suppressor, TP53, activates the innate immune response to suppress tumor growth. TP53 promotes the degradation of the cytosolic DNA exonuclease TREX1, resulting in cytoplasmic DNA accumulation and activation of the cGAS/STING pathway. The absence of cGAS or STING compromises p53’s tumor suppressor activity.
Source: Molecular CellCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @MolecularCell: Online Now: p53 engages the cGAS/STING cytosolic DNA sensing pathway for tumor suppression https://t.co/CiiVhdNqeG
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Mashup Score: 8
Ghosh et al. report that the tumor suppressor, TP53, activates the innate immune response to suppress tumor growth. TP53 promotes the degradation of the cytosolic DNA exonuclease TREX1, resulting in cytoplasmic DNA accumulation and activation of the cGAS/STING pathway. The absence of cGAS or STING compromises p53’s tumor suppressor activity.
Source: Molecular CellCategories: Latest Headlines, Oncologists2Tweet-
RT @ivanoamelio: p53 engages the cGAS/STING cytosolic DNA sensing pathway for tumor suppression: Molecular Cell https://t.co/bCeJ3mp1JQ
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Mashup Score: 1
Bomber et al. utilize degron tagging of the endogenous human chromatin-remodeling enzyme SMARCA5, coupled with a multi-omics approach, to define the requirements for SMARCA5-mediated nucleosome sliding. SMARCA5 co-localized with H2A.Z and CTCF and was required for CTCF DNA binding, nucleosomal phasing at these sites, and maintaining nucleosome repeat length.
Source: Molecular CellCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @MolecularCell: Online Now: Human SMARCA5 is continuously required to maintain nucleosome spacing https://t.co/IELMCqFwqv
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New study linking RNA epitranscriptomic, translation control and splicing in leukemia. @CieslaMaciej @BellodiCristian & co-authors @MolecularCell #AACR23 https://t.co/H8TKPsvwpN