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Mashup Score: 6Reactivation of low avidity tumor-specific CD8+ T cells associates with immunotherapeutic efficacy of anti-PD-1 - 9 month(s) ago
Background CD8+ T cells are a highly diverse population of cells with distinct phenotypic functions that can influence immunotherapy outcomes. Further insights on the roles of CD8+ specificities and TCR avidity of naturally arising tumor-specific T cells, where both high and low avidity T cells recognizing the same peptide-major histocompatibility complex (pMHC) coexist in the same tumor, are crucial for understanding T cell exhaustion and resistance to PD-1 immunotherapy. Methods CT26 models were treated with anti-PD-1 on days 3, 6 and 9 following subcutaneous tumor implantation generating variable responses during early tumor development. Tetramer staining was performed to determine the frequency and avidity of CD8+ T cells targeting the tumor-specific epitope GSW11 and confirmed with tetramer competition assays. Functional characterization of high and low avidity GSW11-specific CD8+ T cells was conducted using flow cytometry and bulk RNA-seq. In vitro cytotoxicity assays and in vivo
Source: jitc.bmj.comCategories: Latest Headlines, Oncologists2Tweet
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Mashup Score: 4Job Details - 9 month(s) ago
We are seeking to appoint a Postdoctoral Researcher to join the research group of Dr. Malcolm Sim in the Oxford Centre for Immuno-Oncology here at the Nuffield Department of Medicine. You will play a key role in driving a novel research program working alongside colleagues in other research groups with similar interests and expertise. This role is a great opportunity to join a vibrant immunology…
Source: my.corehr.comCategories: Latest Headlines, Oncologists2Tweet
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Mashup Score: 1REF 2021: female academics ‘much less likely’ to be submitted - 10 month(s) ago
Ethnicity and disability status also significant factors influencing likelihood of researchers being submitted, report finds
Source: Times Higher Education (THE)Categories: Latest Headlines, Oncologists2Tweet
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Mashup Score: 0Oxford to DSEi - 10 month(s) ago
Everything you need to know about the Pilgrimage from Oxford to London At this stage we’re particularly looking for people with the time and energy to help us organise this pilgrimage. If tha…
Source: Peace PilgrimageCategories: Latest Headlines, Oncologists2Tweet
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Mashup Score: 2WIN 2023 Schedule - 10 month(s) ago
View the schedule for SITC WIN 2023
Source: sitcancer.orgCategories: Latest Headlines, Oncologists2Tweet
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Mashup Score: 2UK has lost out on hundreds of ERC grants amid Horizon delays - Research Professional News - 10 month(s) ago
European Research Council data reveal 337 terminated grants to UK winners, while 41 left country
Source: Research Professional NewsCategories: Latest Headlines, Oncologists2Tweet
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Mashup Score: 0
With visions of the UK as a ‘life sciences superpower’ at risk, we report from Great Ormond Street hospital on what’s being done to give children access to new drugs
Source: the GuardianCategories: Latest Headlines, Oncologists2Tweet
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Mashup Score: 0Junior Research Fellowship in the Northern Ireland Peace Process with the Quill Project (fixed-term, one year) - 1 year(s) ago
Pembroke College proposes to appoint a fixed-term Northern Ireland Peace Process Research Fellow for one year, beginning in October 2023. This is a newly-created, combined post designed to support an academic in the early stages of their career while contributing to the development of the Quill Project’s Writing Peace programme.
Source: www.pmb.ox.ac.ukCategories: Latest Headlines, Oncologists2Tweet
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Mashup Score: 1
Background Differential participation and success in grant applications may contribute to women’s lesser representation in the sciences. This study’s objective was to conduct a systematic review and meta-analysis to address the question of gender differences in grant award acceptance rates and reapplication award acceptance rates (potential bias in peer review outcomes) and other grant outcomes….
Source: BioMed CentralCategories: Latest Headlines, Oncologists2Tweet
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Mashup Score: 1
The Peacock Mentoring Group was created to share learning and support members to implement ways to promote other women in STEM.
Source: Sharon PeacockCategories: Latest Headlines, Oncologists2Tweet
The beauty of low avidity T cells and potential to improve response to immunotherapy - congratulations Tim Elliott @OxfordCancer @DoreenLau4 and the whole team @unisouthampton https://t.co/MzAYEreXSH