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Mashup Score: 3Engineering prostate cancer in vitro: what does it take? - Oncogene - 10 month(s) ago
A key challenge in the clinical management and cause of treatment failure of prostate cancer (PCa) is its molecular, cellular and clinical heterogeneity. Modelling systems that fully recapitulate clinical diversity and resistant phenotypes are urgently required for the development of successful personalised PCa therapies. The advent of the three-dimensional (3D) organoid model has revolutionised…
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 2Significance analysis for clustering with single-cell RNA-sequencing data - Nature Methods - 10 month(s) ago
This study presents a significance analysis framework for evaluating single-cell clusters. Application of the method detects cases of over-clustering in reported single-cell RNA-sequencing analysis results.
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @MCKellySCB: https://t.co/Hk5HEvlDbb
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Mashup Score: 1JCI Insight - LSD1 promotes prostate cancer cell reprogramming by repressing TP53 signaling independently of its demethylase function - 10 month(s) ago
ResearchIn-Press PreviewOncology Open Access | 10.1172/jci.insight.167440 Zhi Duan,2 Diana Flores,1 Chao Zhang,1 Archana Sehrawat,3 Ya-Mei Hu,4 Olivia A. Swaim,1 Eva Rodansky,1 William K. Storck,1 Joshua A. Kuleape,1 Karan Bedi,5 Rahul Mannan,6 Xiao-Ming Wang,6 Aaron M. Udager,6…
Source: insight.jci.orgCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @anbu4genes: Very happy to share our new work out in @JCI_insight- https://t.co/MRUsZ2y7MI. This work was made possible by help and supp…
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Mashup Score: 2Evolution of a minimal cell - Nature - 10 month(s) ago
An engineered minimal cell evolves to escape the negative consequences of genome streamlining.
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet-
Evolution of a minimal cell | Nature @DrJasPlummer @LGMartelotto @MAF_Dawson https://t.co/GchtOSQS3u
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Mashup Score: 1A Q&A with prostate cancer researcher Dr. Amina Zoubeidi - 10 month(s) ago
TFRI reached out to prostate cancer researcher Dr. Amina Zoubeidi to learn more about her cancer research journey, the lessons she’s learned along the way, and the crucial role of collaboration and funding in advancing cancer research.
Source: www.tfri.caCategories: Hem/Oncs, Latest HeadlinesTweet-
A Q&A with prostate cancer researcher Dr. Amina Zoubeidi @PCF_Science @AminaZoubeidi 👏🏼 https://t.co/XqY9UlaqH1
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Mashup Score: 0Fanzor is a eukaryotic programmable RNA-guided endonuclease - Nature - 10 month(s) ago
RNA-guided systems, which employ complementarity between a guide RNA and target nucleic acid sequences for recognition of genetic elements, play a central role in biological processes in both prokaryotes and eukaryotes. For example, the prokaryotic CRISPR-Cas systems provide adaptive immunity for bacteria and archaea against foreign genetic elements. Cas effectors, like Cas9 and Cas12, perform…
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet-
Fanzor is a eukaryotic programmable RNA-guided endonuclease | Nature https://t.co/MUseTeAv3G
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Mashup Score: 3SPEAC-Seq – droplet-based forward genetic screening of astrocyte–microglia cross-talk | RNA-Seq Blog - 10 month(s) ago
Inflammatory neurological diseases, such as multiple sclerosis (MS), can arise when cell-to-cell communication between cells in the central nervous…
Categories: Hem/Oncs, Latest HeadlinesTweet-
RT @juhyunk_: SPEAC-Seq – droplet-based forward genetic screening of astrocyte–microglia cross-talk https://t.co/pLvocHb2ib #journals #feed…
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Mashup Score: 2Now, every biologist can use machine learning | RNA-Seq Blog - 10 month(s) ago
Many biologists could benefit from using machine learning tools to analyze their data and inform their experiments, but few of them have the training required to design and use those tools…
Categories: Hem/Oncs, Latest HeadlinesTweet-
RT @juhyunk_: Now, every biologist can use machine learning https://t.co/in5r0zQxOh #journals #feedly
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Mashup Score: 2Gene regulatory network inference in the era of single-cell multi-omics - Nature Reviews Genetics - 10 month(s) ago
Regulatory circuits of gene expression can be represented as gene regulatory networks (GRNs) that are useful to understand cellular identity and disease. Here, the authors review the computational methods used to infer GRNs — in particular from single-cell multi-omics data — as well as the biological insights that they can provide, and methods for their downstream analysis and experimental…
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @juhyunk_: Gene regulatory network inference in the era of single-cell multi-omics https://t.co/LJ4GM1kGCQ #journals #feedly
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Mashup Score: 11A CRISPR-based method makes T cells that thwart teens’ cancer - 11 month(s) ago
A technique called base editing has been used for the first time to treat human disease.
Source: www.nature.comCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @Nature: A CRISPR-based method makes T cells that thwart teens’ cancer https://t.co/5l2v8bXLRW
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Great overview from @Heer_Lab @Adriana_Buskin @NatashaHepburn4 @PCF_Science Engineering prostate cancer in vitro: what does it take? | Oncogene https://t.co/xMUvSFjipi