• Mashup Score: 3

    Abstract. Cancer cells can undergo plasticity in response to environmental stimuli or under selective therapeutic pressures that result in changes in phenotype. This complex phenomenon of phenotypic plasticity is now recognized as a hallmark of cancer. Lineage plasticity is often associated with loss of dependence on the original oncogenic driver and is facilitated, in part, by underlying genomic…

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    • Very Insightful from ⁦@mishabeltran⁩ lab Significance of RB Loss in Unlocking Phenotypic Plasticity in Advanced Cancers | Molecular Cancer Research | American Association for Cancer Research https://t.co/sgE6GZEfpd

  • Mashup Score: 1

    Nature Cancer encourages preprint sharing as a valuable means of research dissemination and scholarly communication.

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    • RT @NatureCancer: How does @NatureCancer value preprints? Find out about it in our editorial. Find it here👇 https://t.co/kpuG3X5Pkj https…

  • Mashup Score: 12

    Single-cell transcriptomics has emerged as the preferred tool to define cell identity through the analysis of gene expression signatures. However, there are limited studies that have comprehensively compared the performance of different scRNAseq systems in complex tissues. Here, we present a systematic comparison of three well-established high throughput 3’-scRNAseq platforms: Drop-seq, 10x…

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    • RT @FaValdesMora: Excited to share our new pre-print @biorxiv https://t.co/58TwtZPI1O We comprehensively analyse the performance of 3 wide…

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    A high throughput recruitment assay testing the transcriptional activity of more than 100,000 protein fragments tiling across most human chromatin regulators and transcription factors maps the locations and strengths of activation, repression and bifunctional domains, and identifies the sequences necessary for these functions.

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    • RT @lawrensonlab: Large-scale mapping and mutagenesis of human transcriptional effector domains | Nature https://t.co/qEN3orj2k6