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Mashup Score: 1CAR T-cell therapy brings sustained, drug-free remission in three autoimmune diseases - 12 month(s) ago
Single injections of CD19 chimeric antigen receptor T-cell therapy brought long-lasting remission to 15 patients with three different autoimmune diseases, according to data published in The New England Journal of Medicine.“Although antibody-based B-cell targeting certainly improved treatment of autoimmune disease, achieving long-lasting drug-free remission has proven elusive,” Fabian
Source: www.healio.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 5
Autoimmune diseases (ADs) are characterized by loss of immune tolerance, high chronicity, with substantial morbidity and mortality, despite conventional immunosuppression (IS) or targeted disease modifying therapies (DMTs), which usually require repeated administration. Recently, novel cellular therapies (CT), including mesenchymal stromal cells (MSC), Chimeric Antigen Receptors T cells (CART) and regulatory T cells (Tregs), have been successfully adopted in ADs. An international expert panel of the European Society for Blood and Marrow Transplantation and the International Society for the Cell and Gene Therapy, reviewed all available evidence, based on the current literature and expert practices, on use of MSC, CART and Tregs, in AD patients with rheumatological, neurological, and gastroenterological indications.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet-
Innovative cellular therapies for #autoimmune diseases: expert-based position statement and clinical practice recommendations from the EBMT practice harmonisation and guidelines committee https://t.co/hizHbBucIu https://t.co/gVmB71x7Zd
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Mashup Score: 5
Autoimmune diseases (ADs) are characterized by loss of immune tolerance, high chronicity, with substantial morbidity and mortality, despite conventional immunosuppression (IS) or targeted disease modifying therapies (DMTs), which usually require repeated administration. Recently, novel cellular therapies (CT), including mesenchymal stromal cells (MSC), Chimeric Antigen Receptors T cells (CART) and regulatory T cells (Tregs), have been successfully adopted in ADs. An international expert panel of the European Society for Blood and Marrow Transplantation and the International Society for the Cell and Gene Therapy, reviewed all available evidence, based on the current literature and expert practices, on use of MSC, CART and Tregs, in AD patients with rheumatological, neurological, and gastroenterological indications.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet-
Innovative cellular therapies for #autoimmune diseases: expert-based position statement and clinical practice recommendations from the EBMT practice harmonisation and guidelines committee https://t.co/hizHbBucIu https://t.co/gVmB71x7Zd
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Mashup Score: 6Updates on OADR-ORWH | Office of Research on Women's Health - 1 year(s) ago
Virtual Only
Source: orwh.od.nih.govCategories: General Medicine News, RheumatologyTweet-
Interested in #Autoimmune Disease Research at NIH? Join us for our first OADR-Updates for our community partners at The Office of Autoimmune Disease Research. Register here: https://t.co/KimhkHbefi https://t.co/pB4SWqpYZh
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Mashup Score: 137Human IL-17A protein production is controlled through a PIP5K1α-dependent translational checkpoint - 1 year(s) ago
Nuclear enrichment of the phospholipid PIP2 facilitates interleukin-17 translation by CD4+ helper T cells.
Source: www.science.orgCategories: General Medicine News, Future of MedicineTweet-
Scientists delineate how a phospholipid supports the production of an inflammatory molecule that contributes to #autoimmune disease, hinting that this pathway could offer a therapeutic target in conditions such as multiple sclerosis. @SciSignal https://t.co/fQh9Oe1VSa https://t.co/ni6tPneWfV
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Mashup Score: 0FDA grants 510(k) clearance to Werfen’s reagent for connective tissue disease testing - 1 year(s) ago
The FDA has granted 510(k) clearance to Werfen for its Aptiva Connective Tissue Disease Essential reagent to assist in the diagnosis of patients with autoimmune diseases, according to a manufacturer press release.This clearance complements Werfen’s previously cleared Aptiva Celiac Disease IgG reagent, and broadens the offerings of its Aptiva lab system, an automated, high-throughput system
Source: www.healio.comCategories: Latest Headlines, RheumatologyTweet-
📰The FDA has cleared @WerfenNA's newest reagent for #ConnectiveTissueDisease as the company sets its sights on expanding its offerings for other #autoimmune diseases How will this impact patient care? Read more 🔽 https://t.co/cS0MSNFhTr
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Mashup Score: 0Patients hospitalized for rotavirus more likely to develop childhood autoimmune disease - 1 year(s) ago
Children who are hospitalized for rotavirus demonstrate a higher risk for developing juvenile-onset autoimmune diseases, including inflammatory arthritis and vasculitis, according to data published in JAMA Network Open. “Rotavirus infection is a leading cause of mortality and morbidity in infants and young children, and these infections are also linked to autoimmunity,” Eun Kyo Ha,
Source: www.healio.comCategories: Latest Headlines, RheumatologyTweet-
❗Clinicians beware ❗ Children hospitalized due to #rotavirus - a common cause of gastroenteritis - exhibited an increased risk for #autoimmune disease, such as inflammatory #arthritis and vasculitis https://t.co/2OzLiCAGLh
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Mashup Score: 15Integrated single-cell transcriptomics and epigenomics reveals strong germinal center–associated etiology of autoimmune risk loci - 1 year(s) ago
Single-cell ATAC sequencing maps the cell type–specific regulatory potential of transcription factors and autoimmune disease risk loci.
Source: www.science.orgCategories: Allergy-Immunology, Latest HeadlinesTweet-
A 2021 Research Resource for understanding #autoimmune diseases mapped how #genetic mutations could impact immune cell function. @hamish_king @WJGreenleaf @blizard_inst @StanfordMed 📄: https://t.co/bjkSCeVrM5 #WeekendReads https://t.co/TObtUZv6k3
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Mashup Score: 14
T cell–derived IFNγ and CD40L/IL-21R signals are crucial for the differentiation of human T-bethighCD21low B cells.
Source: www.science.orgCategories: Allergy-Immunology, Latest HeadlinesTweet-
A 2021 @UniFreiburg study detailed the development of a #Bcell subset that expands when the adaptive immune system is chronically activated, and is frequently implicated in an array of #autoimmune diseases. Learn more: https://t.co/vcxXzzdCVP #WeekendReads https://t.co/Tj6GYAxvee
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Mashup Score: 1Most Patients With Autoimmune Chronic Spontaneous Urticaria Also Have Autoallergic Urticaria, but Not Vice Versa - 2 year(s) ago
Two endotypes of chronic spontaneous urticaria (CSU) associated with mast cell–activating autoantibodies are described, namely autoallergic chronic spontaneous urticaria (aaCSU; with immunoglobulin E [IgE]–anti-autoallergens) and autoimmune chronic spontaneous urticaria (aiCSU; with IgG–anti-high-affinity receptor for the Fc region of immunoglobulin E [FcεRI]/IgE).
Source: www.jaci-inpractice.orgCategories: Allergy-Immunology, Latest HeadlinesTweet-
In Current Issue! Most #Patients With #Autoimmune #Chronic #Spontaneous #Urticaria Also Have #Autoallergic Urticaria, but Not Vice Versa https://t.co/UKKhE4MurK https://t.co/JbCYTxL3D0
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💥Single injections of CD19 CAR T-cell therapy brought long-lasting remission to 15 patients with three different #autoimmune diseases, according to new data in @NEJM. Find out more at Healio 🔽 https://t.co/2qBjKtte5h