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Mashup Score: 3Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics - 3 year(s) ago
White adipocyte metabolism is important for the regulation of systemic metabolism and is often dysregulated in various conditions, such as cancer and type 2 diabetes mellitus. In this Review, Langin and colleagues provide an overview of lipid metabolism in white adipocytes and the related metabolism of glucose and discuss how these pathways provide therapeutic targets in metabolic disorders.
Source: Nature Reviews EndocrinologyCategories: Endocrinology, Latest HeadlinesTweet
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Mashup Score: 12The cellular and functional complexity of thermogenic fat - 3 year(s) ago
Brown and beige adipocytes are mammalian thermogenic fat cells that regulate whole-body energy metabolism. Notably, brown/beige adipocytes are heterogeneous and their functions extend beyond thermogenesis, encompassing roles as metabolite sinks, as secretory cells and as regulators of adipose tissue homeostasis. Thus, induction of brown/beige fat activity correlates with improved metabolic health.
Categories: Allergy-Immunology, Latest HeadlinesTweet-
A hot #Review (no pun intended!) by Shingo Kajimura&Paul Cohen on the mechanisms of thermogenic fat #BrownAdiposeTissue #Thermogenesis #Adipocytes #Adipogenesis @RockefellerUniv @skajimura @harvardmed https://t.co/VQyY979HF6 FREE online pdf: https://t.co/JCDXjShi2t #sharedit https://t.co/uK2GvkYq2h
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Mashup Score: 15Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics - 3 year(s) ago
White adipocyte metabolism is important for the regulation of systemic metabolism and is often dysregulated in various conditions, such as cancer and type 2 diabetes mellitus. In this Review, Langin and colleagues provide an overview of lipid metabolism in white adipocytes and the related metabolism of glucose and discuss how these pathways provide therapeutic targets in metabolic disorders.
Source: Nature Reviews EndocrinologyCategories: Endocrinology, Latest HeadlinesTweet-
Online now - Pauline Morigny, Jeremie Boucher, Peter Arner & Dominique Langin review current understanding of glucose and lipid #metabolic pathways in white #adipocytes (£) https://t.co/us51tjMBLq https://t.co/SgsgU9lc5O
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Mashup Score: 1Myeloma-Modified Adipocytes Exhibit Metabolic Dysfunction and a Senescence-Associated Secretory Phenotype - 3 year(s) ago
Bone marrow adipocytes (BMAd) have recently been implicated in accelerating bone metastatic cancers, such as acute myelogenous leukemia and breast cancer. Importantly, bone marrow adipose tissue (BMAT) expands with aging and obesity, two key risk factors in multiple myeloma disease prevalence, suggesting that BMAds may influence and be influenced by myeloma cells in the marrow. Here, we provide…
Source: Cancer ResearchCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Fairfield et al show that #TumorCells induce #senescence and metabolic changes in #adipocytes. Targeting senescence in #BoneMarrow adipocytes may be a therapeutic approach to treat #RelapsedMultipleMyeloma. @RedSoxGal0407 @carolyneL24 @Reaganlab4 https://t.co/M6M2QPHali https://t.co/P9jLLlLzvQ
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Mashup Score: 0Myeloma-modified adipocytes exhibit metabolic dysfunction and a senescence-associated secretory phenotype (SASP) - 4 year(s) ago
Bone marrow adipocytes (BMAd) have recently been implicated in accelerating bone metastatic cancers such as acute myelogenous leukemia and breast cancer. Importantly, bone marrow adipose tissue (BMAT) expands with aging and obesity – two key risk factors in multiple myeloma disease prevalence – suggesting that BMAd may influence and be influenced by myeloma cells in the marrow. Here we provide…
Source: Cancer ResearchCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Fairfield et al show that #TumorCells induce #senescence and metabolic changes in #adipocytes. Targeting senescence in #BoneMarrow adipocytes may be a therapeutic approach to treat #RelapsedMultipleMyeloma. @RedSoxGal0407 @carolyneL24 @Reaganlab4 https://t.co/yKVhzwXwOk https://t.co/o9xA409aTX
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Mashup Score: 6
Adipocytes respond to environmental cues, such as metabolic stress, by releasing endocrine factors that modulate diverse physiological processes. This Review discusses the metabolic functions of adipose tissue-derived endocrine hormones and highlights how these factors might contribute to cardiometabolic diseases.
Source: Nature Reviews EndocrinologyCategories: Endocrinology, Latest HeadlinesTweet-
"In obesity, hypertrophic #adipocytes and #adipose tissue-resident immune cells accelerate a chronic, proinflammatory profile with altered secretion of adipokines and lipokines." Find out more here -> https://t.co/jWnBeoHk20 (£) https://t.co/ioMKCCOTKd
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Mashup Score: 6ERα affects mitochondrial function in adipocytes - 4 year(s) ago
Oestrogen receptor-α (ERα) is known to protect against obesity; however, the molecular mechanisms underlying this effect have been unclear. New research now…
Source: Nature Reviews EndocrinologyCategories: Endocrinology, Latest HeadlinesTweet-
Now online: ERα affects #metabolism in white & brown #adipocytes (£) https://t.co/TD2qxoYPnP @zhenqi_zhou @tim_moore8 @briandrew101 @mete_civelek @norheimfrode @MdSindre @marcusseldin @pras48108 @DaneMWolf @MayukoSegawa @OrianShirihai @kerrin_small @AndreaHevener @CADrevon https://t.co/c6F9xmuY7r
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Mashup Score: 0Fungal-like particles and macrophage-conditioned medium are inflammatory elicitors for 3T3-L1 adipocytes - 4 year(s) ago
Adipocytes from white-adipose tissue are known to produce inflammatory cytokines, which play a major role in energy balance and metabolism. While they can respond to pathogen-associated molecular pattern (PAMPs) such as lipopolysaccharide (LPS) from bacteria, it is not known whether adipocytes can be stimulated by fungal cells. Previously, adipocytes were shown to produce toll-like receptor 2…
Source: Scientific ReportsCategories: Infectious Disease, Latest HeadlinesTweet-
Investigators from Prince of Songkla University (@PsuSci) conclude that #fungal-like particles and the conditioned medium elicited an inflammatory response in #adipocytes through the canonical or classical NF-κB pathway. 🍄 https://t.co/Bm3fSlCMQ7 https://t.co/ueljKXJR5M
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Mashup Score: 0Functional Screening of Candidate Causal Genes for Insulin Resistance in Human Preadipocytes and Adipocytes | Circulation Research - 4 year(s) ago
Rationale: Genome-wide association studies have identified genetic loci associated with insulin resistance (IR) but pinpointing the causal genes of a risk locus has been challenging. Objective: To …
Source: www.ahajournals.orgCategories: Cardiology News and JournalsTweet-
Functional screening of human pre- adipocytes & #adipocytes identifies 10 new candidate causal #genes affecting diverse #insulin-sensitizing mechanisms. Learn more about this study by Chen et al at https://t.co/qk1JtE7WMK https://t.co/92ZZ9z1Q8O
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Mashup Score: 1
Attané et al. show that, although human bone marrow adipocytes (BM-Ads) resemble classic white adipocytes on a morphological level, their lipid metabolism is highly specific. They are devoid of lipolytic activity, one of the main metabolic functions of white adipocytes, which explains why they behave like a preserved lipid source under energy-demanding conditions.
Source: Cell ReportsCategories: EndocrinologyTweet-
Human Bone Marrow Is Comprised of #Adipocytes with Specific #Lipid #Metabolism https://t.co/mIczPZGXU8
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Check out this Review in our May issue from @DominiqueLangin and colleagues - Lipid and glucose #metabolism in white #adipocytes: pathways, dysfunction and therapeutics (£) https://t.co/us51tjMBLq https://t.co/Tp6uIKegqe