Lengefeld et al. show that haematopoietic stem cell enlargement explains, at least in part, the reduction of tissue regenerative potential with ageing.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses rely on a cohort of specialized viral proteins to transcribe and replicate their RNA genomes. Recent studies have improved our understanding of coronavirus RNA translation, replication and transcription, and offer new therapeutic targets.

Zimmerli and Allegretti et al. show, in fission yeast, that nuclear pores constrict under energy deprivation or osmotic stress, which is linked to a reduction in nuclear membrane tension.

DNA damage accumulation in zebrafish neurons during wakefulness is detected by Parp1, which induces a homeostatic drive to sleep and repair the damage.

Double-stranded RNAs (dsRNAs) are recognized by designated cellular sensors to mount an immune response. Although dsRNAs are generally of viral origin, dysregulation of several cellular processes can lead to accumulation of endogenous dsRNAs. These self-derived dsRNAs are often associated with immune disorders, but their immunogenicity can also be exploited for immunotherapy.