-
Mashup Score: 146
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses rely on a cohort of specialized viral proteins to transcribe and replicate their RNA genomes. Recent studies have improved our understanding of coronavirus RNA translation, replication and transcription, and offer new therapeutic targets.
Categories: General Medicine Journals and Societies, Latest HeadlinesTweet
-
Mashup Score: 1
Lengefeld et al. show that haematopoietic stem cell enlargement explains, at least in part, the reduction of tissue regenerative potential with ageing.
Categories: Allergy-Immunology, Latest HeadlinesTweet
-
Mashup Score: 12
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses rely on a cohort of specialized viral proteins to transcribe and replicate their RNA genomes. Recent studies have improved our understanding of coronavirus RNA translation, replication and transcription, and offer new therapeutic targets.
Categories: Allergy-Immunology, Latest HeadlinesTweet
-
Mashup Score: 4Cellular origins of dsRNA, their recognition and consequences - Nature Reviews Molecular Cell Biology - 3 year(s) ago
Double-stranded RNAs (dsRNAs) are recognized by designated cellular sensors to mount an immune response. Although dsRNAs are generally of viral origin, dysregulation of several cellular processes can lead to accumulation of endogenous dsRNAs. These self-derived dsRNAs are often associated with immune disorders, but their immunogenicity can also be exploited for immunotherapy.
Categories: Allergy-Immunology, Latest HeadlinesTweet
-
Mashup Score: 0
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses rely on a cohort of specialized viral proteins to transcribe and replicate their RNA genomes. Recent studies have improved our understanding of coronavirus RNA translation, replication and transcription, and offer new therapeutic targets.
Categories: Allergy-Immunology, Latest HeadlinesTweet
-
Mashup Score: 0
Zimmerli and Allegretti et al. show, in fission yeast, that nuclear pores constrict under energy deprivation or osmotic stress, which is linked to a reduction in nuclear membrane tension.
Categories: Allergy-Immunology, Latest HeadlinesTweet
-
Mashup Score: 4
DNA damage accumulation in zebrafish neurons during wakefulness is detected by Parp1, which induces a homeostatic drive to sleep and repair the damage.
Categories: Allergy-Immunology, Latest HeadlinesTweet
-
Mashup Score: 6Cellular origins of dsRNA, their recognition and consequences - Nature Reviews Molecular Cell Biology - 3 year(s) ago
Double-stranded RNAs (dsRNAs) are recognized by designated cellular sensors to mount an immune response. Although dsRNAs are generally of viral origin, dysregulation of several cellular processes can lead to accumulation of endogenous dsRNAs. These self-derived dsRNAs are often associated with immune disorders, but their immunogenicity can also be exploited for immunotherapy.
Categories: Allergy-Immunology, Latest HeadlinesTweet
-
Mashup Score: 19Cellular functions of the protein kinase ATM and their relevance to human disease - Nature Reviews Molecular Cell Biology - 3 year(s) ago
Deficiency in the protein kinase ATM — a master regulator of double-strand DNA breaks and stress responses — causes ataxia telangiectasia (A-T). Recent studies link A-T with other neurodegenerative disorders, and implicate reactive oxygen species, mitochondrial dysfunction, defects in proteostasis and metabolism, and increased poly(ADP-ribosyl)ation in the aetiology of A-T.
Categories: Allergy-Immunology, Latest HeadlinesTweet
-
Mashup Score: 7The molecular principles of gene regulation by Polycomb repressive complexes - Nature Reviews Molecular Cell Biology - 3 year(s) ago
Polycomb repressive complex 1 (PRC1) and PRC2 are important gene regulators in various physiological contexts, especially in development. Recent studies have uncovered the molecular mechanisms that enable mammalian PRC1 and PRC2 to identify their genomic target sites, modify chromatin properties and control transcription.
Categories: Allergy-Immunology, Latest HeadlinesTweet
SARS-CoV-2 and other coronaviruses rely on a cohort of specialized viral proteins to transcribe and replicate their RNA genomes. This Review in @NatRevMCB discusses recent advancements in our understanding of this RNA-synthesizing machinery. https://t.co/VDReqkWEiT https://t.co/iO1Se3WdMV