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Mashup Score: 0
Bioactive small molecules that form covalent bonds with a target protein are important tools for basic research and can be highly effective drugs. This review highlights reactive groups found in a collection of thiophilic and oxophilic drugs that mediate pharmacological activity through a covalent mechanism of action (MOA). We describe the application of advanced proteomic and bioanalytical…
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Mashup Score: 0Copper-catalyzed electrochemical C–H fluorination - 1 year(s) ago
We report the systematic development of an electrochemical method that translates stoichiometric C–H fluorination reactivity of a copper(III) fluoride complex into a catalytic process. The challenges associated with a highly reactive copper(III) species are addressed by the judicious selection of electrolyte, fluoride source, and sacrificial electron acceptor. The catalyst-controlled C–H…
Source: Chem CatalysisCategories: General Medicine News, Latest HeadlinesTweet-
Check out this article "Copper-catalyzed electrochemical C–H fluorination" by @ZhangLabOSU & colleagues, pubished in @ChemCatalysis #ACSSpring2023 https://t.co/48b5X81wDM
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Mashup Score: 1
We developed two molecules based on carbazole and benzotriazole that display brightly emissive properties in both the solution and solid state. The dual-state emission property is facilitated by their twisted structures suppressing the nonradiative pathway caused by deleterious π-π interactions. Moreover, the experimental and theoretical data reveal that high-viscosity media inhibit a…
Source: MatterCategories: General Medicine News, Latest HeadlinesTweet-
Online now in @Matter_CP "Conformational emissive states in dual-state emitters with benzotriazole acceptors" - check out the collaboration by @lianbtd9, @FedeJHernandez, MarioRgz, @JimenezLab, @RCrespoOtero, @MolinaGroup@Matter_CP #ACSSpring2023 https://t.co/Uxi7BQOGGJ
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Mashup Score: 1Developing the Cannabinoid Receptor 2 (CB2) pharmacopoeia: past, present, and future - 1 year(s) ago
Cannabinoid Receptor 2 (CB2) is a G protein-coupled receptor (GPCR) with considerable, though as yet unrealised, therapeutic potential. Promising preclinical data supports the applicability of CB2 activation in autoimmune and inflammatory diseases, pain, neurodegeneration, and osteoporosis. A diverse pharmacopoeia of cannabinoid ligands is available, which has led to considerable advancements in…
Categories: General Medicine News, Latest HeadlinesTweet-
Check out this review on developing the CB2 pharmacopoeia, by Zak M. Whiting, Jiazhen Yin, Sara M. de la Harpe, Andrea J. Vernall & Natasha L. Grimsey @andreav_otago @otago @AucklandUni @ramtash @Trendsinpharma #ACSSpring2023 https://t.co/MB2zLvhz45
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Mashup Score: 3
Proton-electron dual conductors with a well-defined structure allow for efficient charge transport while promoting a fundamental understanding of dual conduction. Herein, we present Zn-HHTP-H2O, a proton-electron dual-conducting MOF, which serves as a functionalizable platform. We found that substituting H2O with urea leaves electrical conductivity nearly the same while increasing proton…
Source: ChemCategories: General Medicine News, Latest HeadlinesTweet-
Check out Jihye Park (@JPdaCheerleader) & colleagues' work on 2D conjugated metal-organic framework as a proton-electron dual conductor - read the full article in @Chem_CP #ACSSpring2023 https://t.co/y9CwNFfqHF
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Mashup Score: 2
The crystal structure of metal NMs is a crucial factor in determining corresponding physical and chemical properties [1–4], indicating that phase control and investigating new-type crystal structures (not represented by well-known crystal structures) are quite important for developing new functions as well as enhancing well-known properties. For that purpose, NMs are attractive because the phase…
Source: Trends in ChemistryCategories: General Medicine News, Latest HeadlinesTweet-
Out now in @TrendsChemistry "Stabilization of unprecedented crystal phases of metal nanomaterials" authored by Toshiharu Teranishi @univkyoto & others #ACSSpring2023 https://t.co/LxYeRuDqHx
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Mashup Score: 0
Catalysis; Organic synthesis; Organic compound
Source: iScienceCategories: General Medicine News, Latest HeadlinesTweet-
Online now: Asymmetric [2+1] cycloaddition of difluoroalkyl-substituted carbenes with alkenes under rhodium catalysis: Synthesis of chiral difluoroalkyl-substituted cyclopropanes, by Xihe Bi @NENU1946 & others @iScience_CP #ACSSpring2023 https://t.co/156dazpOxe
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Mashup Score: 0Cell Press chemistry: Cell Press - 1 year(s) ago
Cell Press is a home for your chemistry research
Source: www.cell.comCategories: General Medicine News, Latest HeadlinesTweet-
Visit our chemistry hub to stay up to date with our primary and review journals, collections, special issues, and webinars #ACSSpring2023 https://t.co/4YwI6oRMvO https://t.co/XpvASZPYFe
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Mashup Score: 3Redox proteomics combined with proximity labeling enables monitoring of localized cysteine oxidation in cells - 1 year(s) ago
Mitochondrial cysteine oxidation regulates diverse pathways. Kisty et al. couple proximity labeling with redox proteomics to measure cysteine oxidation on mitochondrial proteins. Basal levels of oxidation on proteins localized in the matrix and intermembrane space are measured using TurboID. Cysteine oxidation within reactive oxygen species hotspots is determined using APEX.
Source: Cell Chemical BiologyCategories: General Medicine News, Latest HeadlinesTweet-
Check out this study by the lab of Eranthie Weerapana @ChemistryBC in @ChemicalBiology "Redox proteomics combined with proximity labeling enables monitoring of localized cysteine oxidation in cells" #ACSSpring2023 https://t.co/ZVCM8BWU2y
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Mashup Score: 0Reticular chemistry for the rational design of mechanically robust mesoporous merged-net metal-organic frameworks - 1 year(s) ago
Mechanical stability plays a key role in the practical applications of metal-organic frameworks (MOFs). This study provides new insight into the design of high-mechanical-stability MOFs by merging two mechanically fragile frameworks into a more robust framework. A mesoporous MOF with high mechanical stability was synthesized by combining the topological merged-net approach and the introduction of…
Source: MatterCategories: General Medicine News, Latest HeadlinesTweet-
Check this study in @Matter_CP assessing the impact of merging nets on the mechanically stability of MOFs. @HaoJiang15 @o_shekhah @Norahalsadun @Eddaoudi_FMD3@Matter_CP #ACSSpring2023 https://t.co/MdlZER7MdJ
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Check out this review in @Trendsinpharma "Reactive chemistry for covalent probe and therapeutic development" from R. Justin Grams and Ku-Lung Hsu @ChemistryUVA @Hsu_Lab_UVa @GramsJustin #ACSSpring2023 https://t.co/uCPLm57Exz