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Mashup Score: 9Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy - 1 year(s) ago
Bonazzi et al. describe the discovery of clinical candidate NVP-DKY709, a selective degrader of the IKZF2 transcription factor that was identified on the basis of recruitment of IKZF2 to CRBN. NVP-DKY709 treatment reduces suppression by human regulatory T cells in vitro, reduces tumor growth in mice, and degrades IKZF2 in monkeys and humans.
Source: Cell Chemical BiologyCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 4
Liu et al. report DMBP as a methuosis inducer that impedes the membrane fusion events. Further study identifies VPS41 as a potential target of DMBP, through which DMBP inhibits the fusion of late endosomes and autophagosomes with lysosomes.
Source: Cell Chemical BiologyCategories: General Medicine News, Latest HeadlinesTweet-
Targeting VPS41 induces methuosis and inhibits autophagy in cancer cells - read the full article by Hongxiang Lou @ShandongU & colleagues in@CellChemBiol #AACR23 https://t.co/RlkL5ifdMh
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Mashup Score: 3Redox proteomics combined with proximity labeling enables monitoring of localized cysteine oxidation in cells - 1 year(s) ago
Mitochondrial cysteine oxidation regulates diverse pathways. Kisty et al. couple proximity labeling with redox proteomics to measure cysteine oxidation on mitochondrial proteins. Basal levels of oxidation on proteins localized in the matrix and intermembrane space are measured using TurboID. Cysteine oxidation within reactive oxygen species hotspots is determined using APEX.
Source: Cell Chemical BiologyCategories: General Medicine News, Latest HeadlinesTweet-
Check out this study by the lab of Eranthie Weerapana @ChemistryBC in @ChemicalBiology "Redox proteomics combined with proximity labeling enables monitoring of localized cysteine oxidation in cells" #ACSSpring2023 https://t.co/ZVCM8BWU2y
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Mashup Score: 1Structurally distinct PARP7 inhibitors provide new insights into the function of PARP7 in regulating nucleic acid-sensing and IFN-β signaling - 1 year(s) ago
Sanderson et al. describe a potent and selective inhibitor of PARP7. Cellular investigations using this inhibitor confirm PARP7s roles in AHR signaling regulation and type I interferon signaling. This inhibitor will be a useful tool for further studies into PARP7 biology.
Source: Cell Chemical BiologyCategories: General Medicine News, Latest HeadlinesTweet-
Structurally distinct PARP7 inhibitors reveal new insights into the regulation of cytosolic nucleic acid-sensing by PARP7 - find out more from @MichaelNADbio & others in @CellChemBiol #ACSSpring2023 https://t.co/uX8aWJhBVa
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Mashup Score: 7Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy - 1 year(s) ago
Bonazzi et al. describe the discovery of clinical candidate NVP-DKY709, a selective degrader of the IKZF2 transcription factor that was identified on the basis of recruitment of IKZF2 to CRBN. NVP-DKY709 treatment reduces suppression by human regulatory T cells in vitro, reduces tumor growth in mice, and degrades IKZF2 in monkeys and humans.
Source: Cell Chemical BiologyCategories: Hem/Oncs, Latest HeadlinesTweet-
Our first in class therapeutic targeting the Helios transcription factor, here via TPD via molecular glues. New target in the IO landscape, oral therapy. All fingers crossed for anti cancer activity of this program in patients with advanced cancer. https://t.co/lcS6XBexlJ
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Mashup Score: 2Humanized zebrafish as a tractable tool for in vivo evaluation of pro-myelinating drugs - 1 year(s) ago
The identification of drugs that promote remyelination in patients with demyelinating diseases, such as multiple sclerosis, is in high demand. Häberlein et al. introduce a GPR17-humanized zebrafish as proof of principle that fosters in vivo identification of novel pro-remyelination compounds acting via targeted inhibition of human GPR17.
Source: Cell Chemical BiologyCategories: General Medicine News, Latest HeadlinesTweet-
Humanized zebrafish as a tractable tool for in vivo evaluation of pro-myelinating drugs - read the article by Evi Kostenis @UNBonn & colleagues in @CellChemBiol #bps2023 https://t.co/AbiFMtCLO3
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Mashup Score: 0
Bioluminescent probes are routinely used to track biological processes in vitro and in vivo. Multiplexed imaging remains challenging, though, owing to a lack of well-resolved probes and lengthy acquisition times. Brennan et al. report a straightforward platform for rapid, quantitative analyses of bioluminescent mixtures.
Source: Cell Chemical BiologyCategories: General Medicine News, Latest HeadlinesTweet-
Read now in @CellChemBiol "Multiplexed bioluminescence imaging with a generalized substrate unmixing platform" by @jenn_prescher @UCIChemistry & others #bps2023 https://t.co/brid7mejcE
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Mashup Score: 0Identification of proteomic landscape of drug-binding proteins in live cells by proximity-dependent target ID - 1 year(s) ago
Kwak et al. developed a proximity-dependent target-ID system (PROCID) that identifies the proteomic landscape of drug-binding proteins in live cells. This system revealed dasatinib-binding proteins, including SMARCA2, and SAHA-binding proteins. These findings will contribute to the deeper understanding of the modes of action of diverse drugs.
Source: Cell Chemical BiologyCategories: General Medicine News, Latest HeadlinesTweet-
Identification of proteomic landscape of drug-binding proteins in live cells by proximity-dependent target ID (PROCID) - read the full article by Hyun-Woo Rhee @SNUnow et al. in @CellChemBiol #bps2023 https://t.co/0jEeKAddKA
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Mashup Score: 0Real-time non-invasive fluorescence imaging of gut commensal bacteria to detect dynamic changes in the microbiome of live mice - 1 year(s) ago
Imaging of gut microbiota in live animals can provide critical insight into host-microbiome interactions. Apostolos et al. devised a near-infrared imaging strategy based on the specific incorporation of synthetic peptidoglycan precursors, thus providing insights into cell wall biosynthesis and remodeling in live hosts.
Source: Cell Chemical BiologyCategories: General Medicine News, Latest HeadlinesTweet-
Real Time Non-invasive Fluorescence Imaging of Gut Commensal Bacteria to detect dynamic changes in the microbiome of live mice @PiresChemBioLab et al. @CellChemBiol #bps2023 https://t.co/GAOUQykucp
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Mashup Score: 0Structurally distinct PARP7 inhibitors provide new insights into the function of PARP7 in regulating nucleic acid-sensing and IFN-β signaling - 1 year(s) ago
Sanderson et al. describe a potent and selective inhibitor of PARP7. Cellular investigations using this inhibitor confirm PARP7s roles in AHR signaling regulation and type I interferon signaling. This inhibitor will be a useful tool for further studies into PARP7 biology.
Source: Cell Chemical BiologyCategories: General Medicine News, Latest HeadlinesTweet-
Check out this article "Structurally distinct PARP7 inhibitors reveal new insights into the regulation of cytosolic nucleic acid-sensing by PARP7" by @MichaelNADbio @OHSUNews & colleagues, in @CellChemBiol #bps2023 https://t.co/5avSVMoAI6
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Led by Jonathan M. Solomon, researchers @Novartis explore "Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy" @CellChemBiol #AACR23 https://t.co/OcsMxS9XkX