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Mashup Score: 14S P E Y S I D E - 3 month(s) ago
Song · Bon Iver · 2024
Source: open.spotify.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 63Developing a pill to treat sickle cell disease - 6 month(s) ago
A newly identified epigenetic modifier increases fetal hemoglobin in preclinical studies
Source: www.science.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 11AlphaFold 3 predicts the structure and interactions of all of life’s molecules - Isomorphic Labs - 8 month(s) ago
AlphaFold 3 predicts the structure and interactions of all of life’s molecules
Source: www.isomorphiclabs.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 358‘I’m sorry to have to announce that my cancer situation has developed not necessarily to my advantage’ - 9 month(s) ago
MY favourite bit of understatement ever comes not from a Brit or a Spartan but from the Japanese Emperor Hirohito. In August 1945, following Japan’s defeats […]
Source: jerseyeveningpost.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 346‘I’m sorry to have to announce that my cancer situation has developed not necessarily to my advantage’ - 10 month(s) ago
MY favourite bit of understatement ever comes not from a Brit or a Spartan but from the Japanese Emperor Hirohito. In August 1945, following Japan’s defeats […]
Source: jerseyeveningpost.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 84Hinge Moments - 1 year(s) ago
A physician-scientist I have long admired, David Reese, insightfully positions the present era of biomedicine at a “hinge moment”. For the last 20 years, the steady convergence of historically disparate scientific disciplines has availed unprecedented insights into human biology.
Source: www.linkedin.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 106
Redirecting E3 ligases to neo-substrates, leading to their proteasomal disassembly, known as targeted protein degradation (TPD), has emerged as a promising alternative to traditional, occupancy-driven pharmacology. Although the field has expanded tremendously over the past years, the choice of E3 ligases remains limited, with an almost exclusive focus on CRBN and VHL. Here, we report the discovery of novel ligands to the PRY-SPRY domain of TRIM58, a RING ligase that is specifically expressed in erythroid precursor cells. A DSF screen, followed by validation using additional biophysical methods, led to the identification of TRIM58 ligand TRIM-473. A basic SAR around the chemotype was established by utilizing a competitive binding assay employing a short FP peptide probe derived from an endogenous TRIM58 substrate. The X-ray co-crystal structure of TRIM58 in complex with TRIM-473 gave insights into the binding mode and potential exit vectors for bifunctional degrader design.
Source: pubs.acs.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 1BMX - 1 year(s) ago
Hotline TNT · Song · 2023
Source: open.spotify.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 36Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS - 1 year(s) ago
Small molecules recruit cyclophilin A to the active state of mutant KRAS to disrupt oncogenic signaling and tumor growth.
Source: www.science.orgCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0Novartis remibrutinib Phase III trials met their primary endpoints and showed rapid symptom control in chronic spontaneous urticaria - 1 year(s) ago
Ad hoc announcement pursuant to Art. 53 LR Ad hoc announcement pursuant to Art. 53 LR Novartis is a global healthcare company based in Switzerland that provides solutions to address the evolving needs of patients worldwide.
Source: www.novartis.comCategories: Hem/Oncs, Latest HeadlinesTweet
So good to have @boniver back on an acoustic guitar. https://t.co/305zMVLgNz