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Mashup Score: 358‘I’m sorry to have to announce that my cancer situation has developed not necessarily to my advantage’ - 1 month(s) ago
MY favourite bit of understatement ever comes not from a Brit or a Spartan but from the Japanese Emperor Hirohito. In August 1945, following Japan’s defeats […]
Source: jerseyeveningpost.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 346‘I’m sorry to have to announce that my cancer situation has developed not necessarily to my advantage’ - 2 month(s) ago
MY favourite bit of understatement ever comes not from a Brit or a Spartan but from the Japanese Emperor Hirohito. In August 1945, following Japan’s defeats […]
Source: jerseyeveningpost.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 84Hinge Moments - 5 month(s) ago
A physician-scientist I have long admired, David Reese, insightfully positions the present era of biomedicine at a “hinge moment”. For the last 20 years, the steady convergence of historically disparate scientific disciplines has availed unprecedented insights into human biology.
Source: www.linkedin.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 106Discovery of Ligands for TRIM58, a Novel Tissue-Selective E3 Ligase - 6 month(s) ago
Redirecting E3 ligases to neo-substrates, leading to their proteasomal disassembly, known as targeted protein degradation (TPD), has emerged as a promising alternative to traditional, occupancy-driven pharmacology. Although the field has expanded tremendously over the past years, the choice of E3 ligases remains limited, with an almost exclusive focus on CRBN and VHL. Here, we report the discovery of novel ligands to the PRY-SPRY domain of TRIM58, a RING ligase that is specifically expressed in erythroid precursor cells. A DSF screen, followed by validation using additional biophysical methods, led to the identification of TRIM58 ligand TRIM-473. A basic SAR around the chemotype was established by utilizing a competitive binding assay employing a short FP peptide probe derived from an endogenous TRIM58 substrate. The X-ray co-crystal structure of TRIM58 in complex with TRIM-473 gave insights into the binding mode and potential exit vectors for bifunctional degrader design.
Source: pubs.acs.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 1BMX - 6 month(s) ago
Hotline TNT · Song · 2023
Source: open.spotify.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 36Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS - 9 month(s) ago
Small molecules recruit cyclophilin A to the active state of mutant KRAS to disrupt oncogenic signaling and tumor growth.
Source: www.science.orgCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0Novartis remibrutinib Phase III trials met their primary endpoints and showed rapid symptom control in chronic spontaneous urticaria - 9 month(s) ago
Ad hoc announcement pursuant to Art. 53 LR Ad hoc announcement pursuant to Art. 53 LR Novartis is a global healthcare company based in Switzerland that provides solutions to address the evolving needs of patients worldwide.
Source: www.novartis.comCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 2Novartis to buy siRNA developer DTx Pharma for up to $1B - 10 month(s) ago
Novartis will continue to add siRNA capabilities to its tool belt in a deal worth up to $1 billion. The Swiss pharma acquired DTx Pharma, a San Diego-based biotech with a siRNA therapy that it wants to start testing in patients with Carcot-Marie-Tooth disease Type 1A (CMT1A), a neuromuscular disease
Source: Endpoints NewsCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 1Targeted protein degradation reveals BET bromodomains as the cellular target of Hedgehog pathway inhibitor-1 - 10 month(s) ago
Target deconvolution of small molecule hits from phenotypic screens presents a major challenge. Many screens have been conducted to find inhibitors for the Hedgehog signaling pathway – a developmental pathway with many implications in health and …
Source: PubMed Central (PMC)Categories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 1Connor Bedard, as expected, taken first in the NHL draft by the Chicago Blackhawks - 10 month(s) ago
The Chicago Blackhawks have selected Connor Bedard with the first pick in the NHL draft. The move should kick-start a hopeful new era for Chicago.
Source: AP NEWSCategories: Hem/Oncs, Latest HeadlinesTweet
Maybe the most lovely reflection on a life well lived, amidst a cancer diagnosis, that I’ve ever read. By Simon Boas. https://t.co/UtLYOQVQoh