• Mashup Score: 3
    Mycobacterium tuberculosis and SARS-CoV-2 co-infections: the knowns and unknowns - 1 year(s) ago

    Health impacts of Mycobacterium tuberculosis (Mtb) and SARS-CoV-2 co-infections are not fully understood. Both pathogens modulate host responses and induce immunopathology with extensive lung damage. With a quarter of the world’s population harboring latent TB, exploring the relationship between SARS-CoV-2 infection and its effect on the transition of Mtb from latent to active form is paramount…

    Source: iScience
    Categories: Infectious Disease, Latest Headlines
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      infdisease_news

      Starting off this week with a review out of @usask! Researchers highlight dysregulated immune responses induced by SARS-CoV-2 and Mycobacterium #tuberculosis, their potential interplay, and implications for co-infection in the lungs. 📘 @iScience_CP 📑 https://t.co/Lx8OZFZuVB https://t.co/FCXd7CYGO9

  • Mashup Score: 0
    Cell culture systems for isolation of SARS-CoV-2 clinical isolates and generation of recombinant virus - 1 year(s) ago

    A simple and robust cell culture system is essential for generating authentic SARS-CoV-2 stocks required for evaluation of viral pathogenicity, screening of antiviral compounds, and preparation of inactivated vaccines. Evidence suggests that Vero E6, a cell line commonly used in the field to grow SARS-CoV-2, does not support efficient propagation of new viral variants and triggers rapid cell…

    Source: iScience
    Categories: Infectious Disease, Latest Headlines
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      infdisease_news

      🎉 Congratulations to @DaYuanChen1, @drmohsan, and team on their study which generated robust cell culture systems producing highly concentrated #SARSCoV2 stocks, proving to be a valuable tool for studying emerging variants. 📘 @iScience_CP 📑 https://t.co/IBiGJ5tjhz https://t.co/9FcQxOuhMJ

  • Mashup Score: 4
    Genetic control of body weight by the human brain proteome - 1 year(s) ago

    Genome-wide association studies (GWAS) have identified hundreds of genetic variants associated with body weight but the biological relevance of most remains unexplored. Given the critical role of the brain in body weight regulation, we set out to determine whether genetic variants linked with body mass index (BMI) could be mapped to brain proteins. Using genetic colocalization, we mapped 25 loci…

    Source: iScience
    Categories: Cardiologists, Latest Headlines
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    • Profile photo of ArsenaultBenoit
      ArsenaultBenoit

      There's more than a thousand regions in the human genome that influence body weight. In our new paper led by @egagnon_phd, we used Mendelian randomization and genetic colocalization to map dozens of these regions to brain protein levels. https://t.co/2qbeFHcaO0

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