• Mashup Score: 5
    Biomechanical characterization of SARS-CoV-2 spike RBD and human ACE2 protein-protein interaction - 3 year(s) ago

    The current COVID-19 pandemic has led to a devastating impact across the world. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (the virus causing COVID-19) is known to use the receptor-binding domain (RBD) at viral surface spike (S) protein to interact with the angiotensin-converting enzyme 2 (ACE2) receptor expressed on many human cell types. The RBD-ACE2 interaction is a crucial…

    Source: Biophysical Journal
    Categories: General Medicine News, Latest Headlines
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      CellPressNews

      Biomechanical characterization of SARS-CoV-2 spike RBD and human #ACE2 protein-protein interaction from Wonpil Im @LehighU and friends @BiophysJ https://t.co/sMx8ZslsFO https://t.co/K4cR3BPrIT

  • Mashup Score: 8
    SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2 - 3 year(s) ago

    Meet the First Author, see p 1239SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection relies on the binding of S protein (Spike glycoprotein) to ACE (angiotensin-converting enzyme) 2 in the host cells. Vascular endothelium can be infected by SARS-CoV-2,1 which triggers mitochondrial reactive oxygen species production and glycolytic shift.2 Paradoxically, ACE2 is protective in…

    Source: Circulation Research
    Categories: Cardiology News and Journals, Latest Headlines
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      CircRes

      Zhang & colleagues found that the Spike protein alone from #SARS-CoV2 can damage #VascularEndothelialCells by downregulating #ACE2 and consequently inhibiting #mitochondrial function. Learn more at https://t.co/omZWMaDdWM @manorlaboratory https://t.co/AhjPhkk0RE

  • Mashup Score: 2
    The inhibitory effect of a coronavirus spike protein fragment with ACE2 - 3 year(s) ago

    In this article, we investigate the binding processes of a fragment of the coronavirus spike protein receptor binding domain (RBD), the hexapeptide YKYRYL on the angiotensin-converting enzyme 2 (ACE2) receptor, and its inhibitory effect on the binding and activation of the coronavirus-2 spike protein CoV-2 RBD at ACE2. In agreement with an experimental study, we find a high affinity of the…

    Source: Biophysical Journal
    Categories: General Medicine News, Latest Headlines
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      CellPressNews

      The inhibitory effect of a #coronavirus spike protein fragment with #ACE2 @BiophysJ article from Emanuel K. Peter and Alexander Schug @fz_juelich @unidue https://t.co/319r1ZGPTe https://t.co/U067YW7j3l

  • Mashup Score: 0
    COVID-19 and Cardiovascular Disease - 3 year(s) ago

    ARTICLE COVID-19 and Cardiovascular Disease From Bench to Bedside Mina K. Chung, David A. Zidar, Michael R. Bristow, Scott J. Cameron, Timothy Chan, Clifford V. Harding, Deborah H. Kwon, Tamanna Singh, John C. Tilton, Emily J. Tsai, Nathan R. Tucker, John Barnard and Joseph Loscalzo format_quote CITE © 2021 American Heart Association,…

    Source: www.ahajournals.org
    Categories: Cardiologists, Latest Headlines
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      NHLBI_Translate

      .@NIH_NHLBI-funded: Tour de Force. Everything you ever wanted to know about #SARSCoV2 #COVID19: From bench to #bedside. #SpikeProtein #genes #ACE2 #inflammation #thrombosis #Loscalzo @HarvardMed @BroadInstitute @ClevelandClinic @CWRU @ColumbiaMed #COVID_19 https://t.co/QBMB6EGC39 https://t.co/lwLD9x3qOS

  • Mashup Score: 0
    From bedside to bench: regulation of host factors in SARS-CoV-2 infection - 3 year(s) ago

    Aberrant host immune responses probably influence the severity of COVID-19 more than viral activity itself, but more research is needed to understand how the virus and host interact. The effects of SARS-CoV-2 infection vary widely in severity, from asymptomatic cases to multiple organ failure. Simon Biddie at the University of Edinburgh, UK, and co-workers reviewed current knowledge of host…

    Source: Experimental & Molecular Medicine
    Categories: Infectious Disease, Latest Headlines
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      infdisease_news

      In this review, the authors focus on two host factors, angiotensin-converting enzyme 2 (#ACE2) and transmembrane serine protease 2 (#TMPRSS2), implicated in #SARS-CoV-2 infection. Full text: https://t.co/lCxuqpwfJP https://t.co/BLaCkDzKyE

  • Mashup Score: 11
    SARS-CoV-2 infection of the oral cavity and saliva - 3 year(s) ago

    Single-cell transcriptomics and protein expression analyses of salivary glands and gingiva, along with the detection of infectious virus and virus-specific antibodies in saliva from SARS-CoV-2-infected individuals, support a potential role for the oral cavity in COVID-19 pathogenesis.

    Source: Nature Medicine
    Categories: Infectious Disease, Latest Headlines
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      infdisease_news

      Saliva from #SARS-CoV-2-infected individuals harbored epithelial cells exhibiting #ACE2 and TMPRSS expression and sustained SARS-CoV-2 #infection. @UNCDentistry Published in @NatureMedicine 👇 https://t.co/rcJLgen3zX https://t.co/aRYaC6xNes

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