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Mashup Score: 0Role of Ciliary Neurotrophic Factor in Angiotensin II-Induced Hypertension | Hypertension - 2 hour(s) ago
BACKGROUND: Ciliary neurotrophic factor (CNTF), mainly known for its neuroprotective properties, belongs to the IL-6 (interleukin-6) cytokine family. In contrast to IL-6, the effects of CNTF on the vasculature have not been explored. Here, we examined the role of CNTF in AngII (angiotensin II)-induced hypertension. METHODS: Hypertension was chronically induced with AngII (1000 ng/kg per minute, osmotic mini-pumps, 14 days) in CNTF-knockout and wild-type mice (with or without nephrectomy and 1% NaCl drinking water). Blood pressure was measured by tail-cuff and radiotelemetry. Effects of CNTF on vascular function and the JAK2/STAT3 pathway were measured in vivo, in the isolated perfused kidney, and in mouse and human vascular smooth muscle cells. RESULTS: At baseline, systolic blood pressure was similar between both groups. During AngII infusion, blood pressure increase was significantly attenuated and hypertensive heart and kidney damage was significantly attenuated in CNTF-knockout com
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Mashup Score: 1Clonal Hematopoiesis of Indeterminate Potential and Incident Hypertension: Results From the Women’s Health Initiative | Hypertension - 20 hour(s) ago
View all available purchase options and get full access to this article. Bick AG, Weinstock JS, Nandakumar SK, Fulco CP, Bao EL, Zekavat SM, Szeto MD, Liao X, Leventhal MJ, Nasser J, et al; NHLBI Trans-Omics for Precision Medicine Consortium. Inherited causes of clonal haematopoiesis in 97,691 whole genomes. Nature. 2020;586:763–768. doi: 10.1038/s41586-020-2819-2 Breslow NE, Amorim G, Pettinger MB, Rossouw J. Using the whole cohort in the analysis of case-control data: application to the women’s health
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RESEARCH LETTER: Clonal Hematopoiesis of Indeterminate Potential and Incident Hypertension: Results From the Women's Health Initiative https://t.co/YUBHLmcE0f https://t.co/63wV3SCaE3
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Mashup Score: 45Hypotensive Episodes on 24-Hour Ambulatory Blood Pressure and Cognitive Function: Insights From the SPRINT Study | Hypertension - 2 day(s) ago
BACKGROUND: Hypotensive episodes detected by 24-hour ambulatory blood pressure (BP) monitoring capture daily cumulative hypotensive stress and could be clinically relevant to cognitive impairment, but this relationship remains unclear. METHODS: We included participants from the Systolic Blood Pressure Intervention Trial (receiving intensive or standard BP treatment) who had 24-hour ambulatory BP monitoring measured near the 27-month visit and subsequent biannual cognitive assessments. We evaluated the associations of hypotensive episodes (defined as systolic BP drops of ≥20 mm Hg between 2 consecutive measurements that reached <100 mm Hg) and hypotensive duration (cumulative time of systolic BP <100 mm Hg) with subsequent cognitive function using adjusted linear mixed models. We further assessed 24-hour average BP and variability. RESULTS: Among 842 participants with treated hypertension (mean age, 71±9 years; 29% women), the presence (versus absence) of recurrent hypotensive episodes
Source: www.ahajournals.orgCategories: General Medicine NewsTweet-
RESEARCH ARTICLE: Hypotensive Episodes on 24-Hour Ambulatory Blood Pressure and Cognitive Function: Insights From the SPRINT Study @spjuraschek @PDrawz https://t.co/kW2zLjOVai https://t.co/7fmEcOX3XP
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Mashup Score: 4Role of Inflammatory Biomarkers in Mediating Causal Effect of Life Course Body Composition on Hypertension | Hypertension - 3 day(s) ago
BACKGROUND: The mediating role of inflammatory biomarkers in the causal relationship between body composition and hypertension remains unclear and requires further investigation. METHODS: This study used a combination of retrospective observational analysis and Mendelian randomization approaches. Observational data were derived from 4717 Chinese children and adolescents aged 6 to 18 years who underwent dual-energy X-ray absorptiometry to assess body composition. Mendelian randomization analyses utilized summary statistics from large-scale data sets, including UK Biobank, deCODE2021, International Consortium of Blood Pressure, FinnGen, and other consortia. The inflammatory biomarkers included leptin, insulin, adiponectin, osteocalcin, FGF23 (fibroblast growth factor 23), and PTH (parathyroid hormone). RESULTS: The observational analysis revealed that increased fat mass positively influenced diastolic blood pressure through osteocalcin, while fat-free mass had an inverse effect. Insulin
Source: www.ahajournals.orgCategories: General Medicine NewsTweet-
RESEARCH ARTICLE: Role of Inflammatory Biomarkers in Mediating Causal Effect of Life Course Body Composition on Hypertension https://t.co/oFJ3NYr8C4 https://t.co/pWfDU1VPIW
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Mashup Score: 40Hypotensive Episodes on 24-Hour Ambulatory Blood Pressure and Cognitive Function: Insights From the SPRINT Study | Hypertension - 3 day(s) ago
BACKGROUND: Hypotensive episodes detected by 24-hour ambulatory blood pressure (BP) monitoring capture daily cumulative hypotensive stress and could be clinically relevant to cognitive impairment, but this relationship remains unclear. METHODS: We included participants from the Systolic Blood Pressure Intervention Trial (receiving intensive or standard BP treatment) who had 24-hour ambulatory BP monitoring measured near the 27-month visit and subsequent biannual cognitive assessments. We evaluated the associations of hypotensive episodes (defined as systolic BP drops of ≥20 mm Hg between 2 consecutive measurements that reached <100 mm Hg) and hypotensive duration (cumulative time of systolic BP <100 mm Hg) with subsequent cognitive function using adjusted linear mixed models. We further assessed 24-hour average BP and variability. RESULTS: Among 842 participants with treated hypertension (mean age, 71±9 years; 29% women), the presence (versus absence) of recurrent hypotensive episodes
Source: www.ahajournals.orgCategories: General Medicine NewsTweet-
RESEARCH ARTICLE: Hypotensive Episodes on 24-Hour Ambulatory Blood Pressure and Cognitive Function: Insights From the SPRINT Study @spjuraschek @PDrawz https://t.co/kW2zLjOVai https://t.co/7fmEcOX3XP
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Mashup Score: 6Progressive Increase in Renal Sympathetic Nerve Activity Induced by Cold Exposure | Hypertension - 6 day(s) ago
BACKGROUND: Exposure to cold environments is linked to cold-induced hypertension due to activated sympathetic nerve activity (SNA) and arterial baroreceptor reflex dysfunction. However, direct measurement of SNA during cold-induced hypertension and changes in baroreflex control of SNA remain unexplored. METHODS: Chronically instrumented rats were exposed to cold temperatures (10 °C) over 4 days after a control period (24 °C), and renal and lumbar sympathetic nerve activities were simultaneously measured during cold-induced hypertension. Baroreflex curves for renal SNA (RSNA) and lumbar SNA and heart rate were generated by altering arterial pressure via a bolus intravenous infusion of vasoactive drugs. RESULTS: RSNA increased immediately after cold exposure, increased progressively throughout the 4-day period, and remained high after the cold exposure ended. Cold exposure shifted the RSNA baroreflex curve to the right and upward, gradually increasing the upper plateau (maximum capacity
Source: www.ahajournals.orgCategories: General Medicine News, Cardiology News and JournTweet-
EDITORIAL: Left Out in the Cold? The Sympathetic Signature of Cold-Induced Hypertension https://t.co/6WmvB4AiAt https://t.co/7K9ixnGDrQ
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Mashup Score: 0
BACKGROUND: Black individuals frequently present with resistant hypertension and disproportionately increased cardiovascular risk. We investigated the blood pressure (BP)-lowering effect of the dual endothelin receptor antagonist aprocitentan in Black individuals enrolled in the PRECISION study (Parallel-Group, Phase 3 Study with Aprocitentan in Subjects with Resistant Hypertension). METHODS: Patients with confirmed resistant hypertension were randomized to aprocitentan 12.5 mg, 25 mg, or placebo for 4 weeks (part 1). They subsequently received aprocitentan 25 mg for 32 weeks (part 2) before re-randomization to aprocitentan 25 mg or placebo (part 3). RESULTS: Eighty-two patients randomized in the PRECISION study were Black individuals. At week 4, aprocitentan 12.5 and 25 mg reduced office trough systolic BP (−11.3 and −11.9 mm Hg) to a similar degree as placebo (−12.0 mm Hg). Using 24-hour ambulatory BP monitoring, the placebo effect was minimal (−0.7 mm Hg), and aprocitentan reduced s
Source: www.ahajournals.orgCategories: General Medicine NewsTweet-
RESEARCH ARTICLE: Aprocitentan for blood pressure reduction in African American patients @kcferdmd @markus_schlaich https://t.co/XhWkC9vhLU https://t.co/v0ZptzGOXP
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Mashup Score: 2GWAS for Defining the Pathogenesis of Hypertension: Have They Delivered? | Hypertension - 14 day(s) ago
Genome-wide association studies have identified >3500 associated single nucleotide polymorphisms and over 1000 independent loci associated with hypertension. These individually have small effect sizes, and few associated loci have been experimentally tested for causal roles in hypertension using animal models or in humans. Thus, methods to prioritize and maximize the relevance of identified single nucleotide polymorphisms and associated loci are critical to determine their importance in hypertension. We propose several approaches to aid in these efforts, including: (1) integration of genome-wide association study data with multiomic data sets, including proteomics, transcriptomics, and epigenomics, (2) utilizing linked clinical and genetic data sets to determine genetic contributions to hypertension subphenotypes with distinct drivers, and (3) performing whole exome/genome sequencing on cohorts of individuals with severe hypertension to enrich for rare variants with larger effect sizes
Source: www.ahajournals.orgCategories: General Medicine News, Cardiology News and JournTweet-
REVIEW: GWAS for Defining the Pathogenesis of Hypertension: Have They Delivered? https://t.co/AFxLZN5A0e https://t.co/oH5BLwbkue
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Mashup Score: 3Mediation of Social Determinants and Hypertension by Epigenetic Age in CARDIA | Hypertension - 24 day(s) ago
View all available purchase options and get full access to this article. Akinyelure OP, Jaeger BC, Oparil S, Carson AP, Safford MM, Howard G, Muntner P, Hardy ST. Social determinants of health and uncontrolled blood pressure in a national cohort of Black and White US adults: the REGARDS study. Hypertension. 2023;80:1403–1413. doi: 10.1161/HYPERTENSIONAHA.122.20219 Akinyelure OP, Jaeger BC, Safford MM, Oparil S, Carson AP, Sims A, Hannon L, Howard G, Muntner P, Hardy ST. Social determinants of health and
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
RESEARCH LETTER: Mediation of Social Determinants and Hypertension by Epigenetic Age in CARDIA https://t.co/4OZ7yOL7nG
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Mashup Score: 2Trends in Obesity Prevalence Among Adults With Hypertension in the United States, 2001 to 2023 | Hypertension - 1 month(s) ago
BACKGROUND: Obesity is a factor contributing to the occurrence of hypertension and a risk factor for adverse outcomes in populations with hypertension. The changes in the prevalence of obesity in populations with hypertension remain unclear. Investigating the changes in the prevalence of obesity in populations with hypertension can provide information for the treatment and management of hypertension. METHODS: The clinical data from adults aged ≥20 years with hypertension were extracted from the National Health and Nutrition Examination Survey 2001 to 2023. The primary outcome was the prevalence of obesity (body mass index≥30 kg/m2). The trend in the prevalence of obesity among American adults with hypertension was evaluated via a trend test. RESULTS: The age-standardized prevalence of obesity among populations with hypertension in America increased from 39.6% in 2001 to 55.4% in 2023 (P for trend<0.001). This trend was observed in men (35.4%–53.6%; P for trend<0.001) and women (45.6%–5
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
RESEARCH ARTICLE: Trends in Obesity Prevalence Among Adults With Hypertension in the United States, 2001 to 2023 https://t.co/xYb8NIwkOr https://t.co/OvosrPAlrT
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RESEARCH ARTICLE: Role of Ciliary Neurotrophic Factor in Angiotensin II-Induced Hypertension https://t.co/vMkvRpM5V7 https://t.co/gXxtzJd2nm