Primary hypertension (hypertension) is a complex trait, a heterogeneous disease that develops due to multiple causal pathways involving genes and gene-environment interactions. 1 Uncovering the involved genetic variants holds the promise of personalized medicine for hypertension. The genetic research of complex and polygenic human diseases, such as hypertension, has made considerable progress over the past > 10 years. Much of it has been driven by technological advances in assessing the human genome

Hypertension remains highly prevalent worldwide and largely uncontrolled. In addition to lifestyle modification and drug therapy, catheter-based renal denervation (RDN) is an additional and complementary treatment option. 1 The recently reported global, randomized, blinded, sham-controlled Global Clinical Study of Renal Denervation With the Symplicity Spyral™ Multi-electrode Renal Denervation System in Patients With Uncontrolled Hypertension on Standard Medical Therapy (SPYRAL HTN-ON MED) trial of

View all available purchase options and get full access to this article. Van Bortel LM, Laurent S, Boutouyrie P, Chowienczyk P, Cruickshank JK, De Backer T, Filipovsky J, Huybrechts S, Mattace-Raso FU, Protogerou AD, Schillaci G. Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity. J Hypertens. 2012;30:445–448. doi: 10.1097/HJH.0b013e32834fa8b0 Spronck B, Delhaas T, Op‘t Roodt J, Reesink KD. Carotid artery applanation tonometry does

BACKGROUND: Postural orthostatic tachycardia syndrome (POTS) is a frequently diagnosed cardiovascular disorder after COVID-19 infection. POTS is characterized by the presence of excessive sinus tachycardia on standing without a fall in blood pressure (BP). We investigated the BP profile using 24-hour ambulatory BP monitoring in patients with new-onset POTS after COVID-19 compared with prepandemic population-based controls. METHODS: We performed a case-control study in 100 patients (mean age, 40.0±12.9 years; 85% women) with verified post–COVID-19 new-onset POTS diagnosed by a positive head-up tilt testing versus 100 controls from a population-based cohort with a negative active standing test, no history of syncope, POTS, or endocrine disease (mean age, 42.3±14.0 years; 78% women). Twenty-four-hour BP profile was assessed for circadian BP variation including hypotensive systolic BP (SBP) episodes (<80, <90, and <100 mm Hg). RESULTS: Patients with post–COVID-19 POTS had significantly hig