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Mashup Score: 4Ductal carcinoma in situ of the breast: finding the balance between overtreatment and undertreatment - 2 hour(s) ago
Ductal carcinoma in situ (DCIS) accounts for 15–25% of all breast cancer diagnoses. Its prognosis is excellent overall, the main risk being the occurrence of local breast events, as most cases of DCIS do not progress to invasive cancer. Systematic screening has greatly increased the incidence of this non-obligate precursor of invasion, lending urgency to the need to identify DCIS that is prone to invasive progression and distinguish it from non-invasion-prone DCIS, as the latter can be overdiagnosed and therefore overtreated.
Source: www.thelancet.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 9Motor neuron disease: improving quality of life for patients - 6 hour(s) ago
This week, The Lancet published the findings from COMMEND, the largest clinical trial to date of a psychological intervention for people with motor neuron disease (MND). This devastating, incurable neurodegenerative disease results from the loss of motor neurons in the motor cortex and spinal cord, causing progressive paralysis and eventual death. More than half of people with MND die within 2 years of a diagnosis. Rates of depression and anxiety in patients are high. Given the dire prognosis, interventions that can improve the quality of remaining life for patients are vital.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 3A proposed clinical classification for pituitary neoplasms to guide therapy and prognosis - 9 hour(s) ago
No comprehensive classification system that guides prognosis and therapy of pituitary adenomas exists. The 2022 WHO histopathology-based classification system can only be applied to lesions that are resected, which represent few clinically significant pituitary adenomas. Many factors independent of histopathology provide mechanistic insight into causation and influence prognosis and treatment of pituitary adenomas. We propose a new approach to guide prognosis and therapy of pituitary adenomas by integrating clinical, genetic, biochemical, radiological, pathological, and molecular information for all adenomas arising from anterior pituitary cell lineages.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 45Endocrine health in survivors of adult-onset cancer - 10 hour(s) ago
Long-term survivors of cancer (ie, the patient who is considered cured or for whom the disease is under long-term control and unlikely to recur) are at an increased risk of developing endocrine complications such as hypothalamic–pituitary dysfunctions, hypogonadisms, osteoporosis, or metabolic disorders, particularly when intensive tumour-directed therapies are applied. Symptom severity associated with these conditions ranges from mild and subclinical to highly detrimental, affecting individual health and quality of life.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 306Contribution of vaccination to improved survival and health: modelling 50 years of the Expanded Programme on Immunization - 11 hour(s) ago
Since 1974 substantial gains in childhood survival have occurred in every global region. We estimate that EPI has provided the single greatest contribution to improved infant survival over the past 50 years. In the context of strengthening primary health care, our results show that equitable universal access to immunisation remains crucial to sustain health gains and continue to save future lives from preventable infectious mortality.
Source: www.thelancet.comCategories: General Medicine News, Expert PicksTweet
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Mashup Score: 5
Prostate cancer is the most common cancer in men in 112 countries, and accounts for 15% of cancers. In this Commission, we report projections of prostate cancer cases in 2040 on the basis of data for demographic changes worldwide and rising life expectancy. Our findings suggest that the number of new cases annually will rise from 1·4 million in 2020 to 2·9 million by 2040. This surge in cases cannot be prevented by lifestyle changes or public health interventions alone, and governments need to prepare strategies to deal with it.
Source: www.thelancet.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 4MDA5-autoimmunity and interstitial pneumonitis contemporaneous with the COVID-19 pandemic (MIP-C) - 23 hour(s) ago
A distinct pattern of MDA5-autoimmunity cases surged contemporaneously with circulation of the SARS-COV-2 virus during COVID-19. Bioinformatic insights suggest a shared immunopathology with known autoimmune lung disease mechanisms.
Source: www.thelancet.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 42Organisations vie for control over pandemic financing - 1 day(s) ago
Global health organisations are competing for influence over financing for pandemic preparedness and response in the new pandemic accord. By Ann Danaiya Usher.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 0
Findings suggest that the effectiveness of CBT on general and positive symptoms in SSD at EoT was small to medium, while we found inconsistent evidence for a sustainable effect. CBT has no convincing impact on other relevant outcomes. Guidelines may use these results to specify their recommendations.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 150Metabolic health and cardiometabolic risk clusters: implications for prediction, prevention, and treatment - 1 day(s) ago
Among 20 leading global risk factors for years of life lost in 2040, reference forecasts point to three metabolic risks—high blood pressure, high BMI, and high fasting plasma glucose—as being the top risk variables. Building upon these and other risk factors, the concept of metabolic health is attracting much attention in the scientific community. It focuses on the aggregation of important risk factors, which allows the identification of subphenotypes, such as people with metabolically unhealthy normal weight or metabolically healthy obesity, who strongly differ in their risk of cardiometabolic diseases.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
In this review @TheLancet , S Delaloge @GustaveRoussy & coll discuss how risk assessment could improve the quality of care in pts with in situ breast carcinoma. This risk-based approach is the foundation of modern cancer prevention centers https://t.co/gYQo7LvKvH