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Mashup Score: 0Nitrous oxide-induced myeloneuropathy: a case series - 11 month(s) ago
Background Nitrous oxide (N2O) is the second most common recreational drug used by 16- to 24-year-olds in the UK. Neurological symptoms can occur in some people that use N2O recreationally, but most information comes from small case series. Methods We describe 119 patients with N2O-myeloneuropathy seen at NHS teaching hospitals in three of the UK’s largest cities: London, Birmingham and…
Categories: General Medicine Journals and Societies, Latest HeadlinesTweet
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Mashup Score: 3Association of age and inflammatory disease activity in the pivotal natalizumab clinical trials in relapsing-remitting multiple sclerosis - 12 month(s) ago
Background Focal inflammatory disease activity in relapsing-remitting multiple sclerosis (RRMS) diminishes with increasing age. Here we use patient-level data from randomised controlled trials (RCTs) of natalizumab treatment in RRMS to investigate the association of age and inflammatory disease activity. Methods We used patient-level data from the AFFIRM (natalizumab vs placebo in…
Categories: Latest Headlines, NeurologyTweet-
"Patient age should be taken into consideration when deciding on immunomodulatory treatment in RRMS" https://t.co/iTMClW2Cnr
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Mashup Score: 15Motor cortex functional connectivity is associated with underlying neurochemistry in ALS - 1 year(s) ago
Objective To identify structural and neurochemical properties that underlie functional connectivity impairments of the primary motor cortex (PMC) and how these relate to clinical findings in amyotrophic lateral sclerosis (ALS). Methods 52 patients with ALS and 52 healthy controls, matched for age and sex, were enrolled from 5 centres across Canada for the Canadian ALS Neuroimaging Consortium…
Categories: General Medicine News, Latest HeadlinesTweet-
Researchers pinpoint neurochemical marker linked with loss of motor function in ALS @ualberta https://t.co/0YgwSxfGG5 https://t.co/kROfKMKbIB
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Mashup Score: 1Visual dysfunction is a better predictor than retinal thickness for dementia in Parkinson’s disease - 1 year(s) ago
Background Dementia is a common and devastating symptom of Parkinson’s disease (PD). Visual function and retinal structure are both emerging as potentially predictive for dementia in Parkinson’s but lack longitudinal evidence. Methods We prospectively examined higher order vision (skew tolerance and biological motion) and retinal thickness (spectral domain optical coherence tomography) in 100…
Categories: Latest Headlines, NeurologyTweet-
Visual dysfunction is a better predictor than retinal thickness for dementia in Parkinsons disease https://t.co/VgOibgX1gf
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Mashup Score: 1Granulocyte activation markers in cerebrospinal fluid differentiate acute neuromyelitis spectrum disorder from multiple sclerosis - 1 year(s) ago
Background Granulocyte invasion into the brain is a pathoanatomical feature differentiating neuromyelitis optica spectrum disorder (NMOSD) from multiple sclerosis (MS). We aimed to determine whether granulocyte activation markers (GAM) in cerebrospinal fluid (CSF) can be used as a biomarker to distinguish NMOSD from MS, and whether levels associate with neurological impairment. Methods We…
Categories: Latest Headlines, NeurologyTweet-
Granulocyte activation markers in cerebrospinal fluid differentiate acute neuromyelitis spectrum disorder from multiple sclerosis https://t.co/5ULx9G5DAF
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Mashup Score: 0Timing of physical activity across adulthood on later-life cognition: 30 years follow-up in the 1946 British birth cohort - 1 year(s) ago
Background To assess how timing, frequency and maintenance of being physically active, spanning over 30 years in adulthood, is associated with later-life cognitive function. Methods Participants (n=1417, 53% female) were from the prospective longitudinal cohort study, 1946 British birth cohort. Participation in leisure time physical activity was reported five times between ages 36 and 69,…
Categories: Healthcare Professionals, Latest HeadlinesTweet-
Here’s latest study: https://t.co/a2lejJ5NcT “Being physically active at any time in adulthood, and to any extent, is linked with higher later-life cognitive state, but lifelong maintenance of physical activity was most optimal.” MOVE! #exercise #fit #brain
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Mashup Score: 1Blood biomarkers: ready for clinical practice? - 1 year(s) ago
Most people would want to know early, if they had Alzheimer’s disease (AD).1 Potential new treatments, such as lecanemab, require early molecular AD diagnosis.2 Yet, very few clinic patients receive a molecular diagnosis (only ~1% in the UK), around 40% of people with dementia are never diagnosed and most diagnoses occur relatively late in the course of the illness.3 Amyloid and tau…
Categories: Latest Headlines, Rare DiseaseTweet-
RT @BrielmaierL: Blood biomarkers: ready for clinical practice? https://t.co/XSRlr7nc2E Same old song and dance, no validation studies.
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Mashup Score: 2
Background The key Alzheimer’s disease (AD) biomarkers are traditionally measured with techniques/exams that are either expensive (amyloid-positron emission tomography (PET) and tau-PET), invasive (cerebrospinal fluid Aβ42 and p-tau181), or poorly specific (atrophy on MRI and hypometabolism on fluorodeoxyglucose-PET). Recently developed plasma biomarkers could significantly enhance the efficiency…
Categories: General Medicine News, Latest HeadlinesTweet-
Blood-based biomarkers for #Alzheimer'sdisease could greatly simplify diagnosis and reduce costs https://t.co/EoLJPCchTh https://t.co/9IGLkbNrxi
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Mashup Score: 0
Background The key Alzheimer’s disease (AD) biomarkers are traditionally measured with techniques/exams that are either expensive (amyloid-positron emission tomography (PET) and tau-PET), invasive (cerebrospinal fluid Aβ42 and p-tau181), or poorly specific (atrophy on MRI and hypometabolism on fluorodeoxyglucose-PET). Recently developed plasma biomarkers could significantly enhance the efficiency…
Categories: Latest Headlines, NeurologyTweet-
Plasma biomarkers for Alzheimers disease: a field-test in a memory clinic https://t.co/ikrQDPi0oy
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Mashup Score: 2
Background Ageing is a major risk factor for Alzheimer’s disease (AD), which is accompanied by cellular senescence and thousands of transcriptional changes in the brain. Objectives To identify the biomarkers in the cerebrospinal fluid (CSF) that could help differentiate healthy ageing from neurodegenerative processes. Methods Cellular senescence and ageing-related biomarkers were assessed in…
Categories: Latest Headlines, NeurologyTweet-
Molecules of senescent glial cells differentiate Alzheimers disease from ageing https://t.co/R0JD3Fl8zq
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Predominance of young Asian men among large UK case series of laughing gas users published by @JNNP_BMJ https://t.co/oxSuVJg2lt