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Mashup Score: 0Elevated plasma p-tau181 levels unrelated to Alzheimer’s disease pathology in amyotrophic lateral sclerosis - 1 year(s) ago
Background Phosphorylated-tau181 (p-tau181), a specific marker of Alzheimer’s disease (AD) pathology, was found elevated in plasma but not in cerebrospinal fluid (CSF) of patients with amyotrophic lateral sclerosis (ALS). We expanded these findings in a larger patient cohort, exploring clinical/electrophysiological associations, prognostic value and longitudinal trajectories of the…
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Mashup Score: 3Plasma inflammation for predicting phenotypic conversion and clinical progression of autosomal dominant frontotemporal lobar degeneration - 1 year(s) ago
Background Measuring systemic inflammatory markers may improve clinical prognosis and help identify targetable pathways for treatment in patients with autosomal dominant forms of frontotemporal lobar degeneration (FTLD). Methods We measured plasma concentrations of IL-6, TNFα and YKL-40 in pathogenic variant carriers ( MAPT, C9orf72, GRN ) and non-carrier family members enrolled in the…
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Mashup Score: 33Functional neurological disorder is a feminist issue - 1 year(s) ago
Functional neurological disorder (FND) is a common and disabling disorder, often misunderstood by clinicians. Although viewed sceptically by some, FND is a diagnosis that can be made accurately, based on positive clinical signs, with clinical features that have remained stable for over 100 years. Despite some progress in the last decade, people with FND continue to suffer subtle and overt forms…
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Mashup Score: 15Timing of physical activity across adulthood on later-life cognition: 30 years follow-up in the 1946 British birth cohort - 1 year(s) ago
Background To assess how timing, frequency and maintenance of being physically active, spanning over 30 years in adulthood, is associated with later-life cognitive function. Methods Participants (n=1417, 53% female) were from the prospective longitudinal cohort study, 1946 British birth cohort. Participation in leisure time physical activity was reported five times between ages 36 and 69,…
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Mashup Score: 1Functional neurological disorders after COVID-19 and SARS-CoV-2 vaccines: a national multicentre observational study - 1 year(s) ago
Functional neurological disorders (FNDs) are a common cause of neurology consultations.1 Dissociative seizures, motor and cognitive disorders are the main phenotypes. Diagnosis is made on positive terms: signs of inconsistency, incongruence and variability of physical signs with attention on clinical examination.1 Abnormal emotional processing and expectations are involved in the genesis and…
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Mashup Score: 3
Objective To investigate the aetiology, subsequent preventive strategies and outcomes of stroke despite anticoagulation in patients with atrial fibrillation (AF). Methods We analysed consecutive patients with AF with an index imaging-proven ischaemic stroke despite vitamin K-antagonist (VKA) or direct oral anticoagulant (DOAC) treatment across 11 stroke centres. We classified stroke aetiology…
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Mashup Score: 4Timing of physical activity across adulthood on later-life cognition: 30 years follow-up in the 1946 British birth cohort - 1 year(s) ago
Background To assess how timing, frequency and maintenance of being physically active, spanning over 30 years in adulthood, is associated with later-life cognitive function. Methods Participants (n=1417, 53% female) were from the prospective longitudinal cohort study, 1946 British birth cohort. Participation in leisure time physical activity was reported five times between ages 36 and 69,…
Categories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 1Timing of physical activity across adulthood on later-life cognition: 30 years follow-up in the 1946 British birth cohort - 1 year(s) ago
Background To assess how timing, frequency and maintenance of being physically active, spanning over 30 years in adulthood, is associated with later-life cognitive function. Methods Participants (n=1417, 53% female) were from the prospective longitudinal cohort study, 1946 British birth cohort. Participation in leisure time physical activity was reported five times between ages 36 and 69,…
Categories: Healthcare Professionals, Latest HeadlinesTweet
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Mashup Score: 2Timing of physical activity across adulthood on later-life cognition: 30 years follow-up in the 1946 British birth cohort - 1 year(s) ago
Background To assess how timing, frequency and maintenance of being physically active, spanning over 30 years in adulthood, is associated with later-life cognitive function. Methods Participants (n=1417, 53% female) were from the prospective longitudinal cohort study, 1946 British birth cohort. Participation in leisure time physical activity was reported five times between ages 36 and 69,…
Categories: Healthcare Professionals, Latest HeadlinesTweet
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Mashup Score: 2Timing of physical activity across adulthood on later-life cognition: 30 years follow-up in the 1946 British birth cohort - 1 year(s) ago
Background To assess how timing, frequency and maintenance of being physically active, spanning over 30 years in adulthood, is associated with later-life cognitive function. Methods Participants (n=1417, 53% female) were from the prospective longitudinal cohort study, 1946 British birth cohort. Participation in leisure time physical activity was reported five times between ages 36 and 69,…
Categories: Latest Headlines, NeurologyTweet
"The finding indicates that p-tau181 of putative peripheral origin might represent a confounding factor in using plasma p-tau181 for AD pathology screening..." https://t.co/PWYyF36vjz