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A temporal perspective for tumor-associated macrophage identities and functions
Tumor-associated macrophages (TAMs) are well known to fuel tumor evolution. Blériot et al. advocate for integrating the time dimension when conceptualizing macrophage diversity in pre-malignancy and cancer…
A temporal perspective for tumor-associated macrophage identities and functions
Tumor-associated macrophages (TAMs) are well known to fuel tumor evolution. Blériot et al. advocate for integrating the time dimension when conceptualizing macrophage diversity in pre-malignancy and cancer…
Short-distance vesicle transport via phase separation
Using the reconstituted presynaptic terminal local vesicle transport as a paradigm, Qiu and Wu et al. demonstrate that short-distance and directional vesicle transport can be achieved…
A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2
Cells carrying a monoallelic germline BRCA2 mutation can bypass Knudson’s “two-hit” requirement to initiate tumorigenesis when the glycolytic metabolite methylglyoxal transiently disables BRCA2 function. Metabolic…
Creation of a structured solar cell material dataset and performance prediction using large language models
This study explores the transformative power of big data in materials science, tackling the long-standing issue of data harnessability. The authors introduce a one-step approach…
Fabrication of a hierarchical NiTe@NiFe-LDH core-shell array for high-efficiency alkaline seawater oxidation
Materials chemistry; Energy materials
Flexible scaffold-based cheminformatics approach for polypharmacological drug design
The flexible scaffold-based cheminformatics approach (FSCA) unlocks the potential of drug design to create polypharmacological drugs that open up treatment possibilities for complex brain disorders.
Tumor cell-intrinsic epigenetic SETpoint of cancer-associated fibroblasts
Cancer-associated fibroblasts (CAFs) exhibit spatial and functional diversity. Here, Niu et al. unveil SETD2’s function in lipid metabolism and CAF heterogeneity in pancreatic ductal adenocarcinoma. SETD2…
Unveiling transport mechanisms of cesium and water in operando zero-gap CO2 electrolyzers
In CO2 electrolyzers, balancing water and cations is vital. Through operando wide-angle scattering and fluorescence X-ray techniques, we observed H2O and Cs+ dynamics in the…
Exploring new perspectives in immunology
Despite deep knowledge of how the immune system works, many questions remain difficult to answer within the current core framework of innate and adaptive immunity.…