A temporal perspective for tumor-associated macrophage identities and functions
Tumor-associated macrophages (TAMs) are well known to fuel tumor evolution. Blériot et al. advocate for integrating the time dimension when conceptualizing macrophage diversity in pre-malignancy and cancer and propose the term “PreTAMs” to emphasize their early roles in orchestrating inflammatory responses that often precede, and not just result from, tumor onset.