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Mashup Score: 4Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual Is Associated with Conserved Epigenetic Erosion - 1 month(s) ago
A human germline-mosaic for WT and DNMT3A mutant cells reveals a marked advantage for DNMT3A mutant cells in the hematopoietic system compared to epithelial cells. Deep sequencing suggests a very early tissue advantage driven by DNA methylation loss at conserved loci rather than increased mutation burden.
Source: www.cell.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 4Tissue mosaicism following stem cell aging: blood as an exemplar - 2 month(s) ago
Nature Aging – Tissue mosaicism, driven by somatically acquired changes, is an emerging hallmark of aging. This Review coalesces recent discoveries from the hematopoietic system to integrate this…
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 2A twist to splicing regulation in haematopoiesis - 1 year(s) ago
DNMT3A is best known for its de novo DNA methyltransferase activity. But a new study shows that the protein also has a role in RNA splicing during activation of embryonic and haematopoietic stem cells. This introduces a new perspective for approaching diseases associated with DNMT3A mutations.
Source: www.nature.comCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 2Department of Molecular and Cellular Biology - 1 year(s) ago
The Department of Molecular & Cellular Biology at Baylor College of Medicine is devoted to research, education, and clinical discoveries….
Source: Baylor College of MedicineCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 2Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis - 2 year(s) ago
Normal adipogenesis requires de novo DNA methyltransferase 3A (DNMT3A) for proper differentiation and suppression of an age-associated pathogenic inflammatory program.
Source: eLifeCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0The disordered N-terminal domain of DNMT3A recognizes H2AK119ub and is required for postnatal development - 2 year(s) ago
DNA methyltransferase 3a (DNMT3A) plays a crucial role during mammalian development. Two isoforms of DNMT3A are differentially expressed from stem cells to somatic tissues, but their individual functions remain largely uncharacterized. Here we report that the long isoform DNMT3A1, but not the short DNMT3A2, is essential for mouse postnatal development. DNMT3A1 binds to and regulates bivalent…
Source: www.nature.comCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0
A new study demonstrates that the disordered N-terminal domain of DNMT3A1 binds PRC1-catalyzed H2AK119ub, targeting DNA methylation to bivalent promoters in mouse brain cortical cells. Methylation around bivalent genes is critical for mouse postnatal development, and could be equally important in other cell types and in disease.
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 11Two competing mechanisms of DNMT3A recruitment regulate the dynamics of de novo DNA methylation at PRC1-targeted CpG islands - Nature Genetics - 2 year(s) ago
DNMT3A PWWP domain mutations promote localization of DNMT3A to CpG islands in a PRC1-dependent manner. DNMT3A interacts with H2AK119ub-modified nucleosomes.
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 25Please wait whilst we redirect you - 2 year(s) ago
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Source: www.sciencedirect.comCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 3Director of Human Stem Cell Core, Assistant Professor - 3 year(s) ago
Director of Human Stem Cell Core, Assistant Professor
Source: jobs.bcm.eduCategories: Hem/Oncs, Latest HeadlinesTweet
Embryonic-derived mosaicism is likely highly under-appreciated and yet can have significant implications for the identification, management, and transmission of a variety of conditions. Eg #TBRS #DNMT3A @TBRSCommunity https://t.co/KcLRUEheA9