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Mashup Score: 4Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual Is Associated with Conserved Epigenetic Erosion - 13 day(s) ago
A human germline-mosaic for WT and DNMT3A mutant cells reveals a marked advantage for DNMT3A mutant cells in the hematopoietic system compared to epithelial cells. Deep sequencing suggests a very early tissue advantage driven by DNA methylation loss at conserved loci rather than increased mutation burden.
Source: www.cell.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 4Tissue mosaicism following stem cell aging: blood as an exemplar - 2 month(s) ago
Nature Aging – Tissue mosaicism, driven by somatically acquired changes, is an emerging hallmark of aging. This Review coalesces recent discoveries from the hematopoietic system to integrate this…
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet-
📢 Happy to announce our new review on stem cell #aging! We integrate traditional concepts/hallmarks of aging with emerging data on somatic evolution and stem cell competition. @NatureAging https://t.co/3mbNNMzNkk
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Mashup Score: 2A twist to splicing regulation in haematopoiesis - 1 year(s) ago
DNMT3A is best known for its de novo DNA methyltransferase activity. But a new study shows that the protein also has a role in RNA splicing during activation of embryonic and haematopoietic stem cells. This introduces a new perspective for approaching diseases associated with DNMT3A mutations.
Source: www.nature.comCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @NatureCellBio: Read also the News & Views article on the study written by Maria Carmo-Fonseca: PDF: https://t.co/K4cfMGhJZ2 https://t.c…
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Mashup Score: 2Department of Molecular and Cellular Biology - 1 year(s) ago
The Department of Molecular & Cellular Biology at Baylor College of Medicine is devoted to research, education, and clinical discoveries….
Source: Baylor College of MedicineCategories: Hem/Oncs, Latest HeadlinesTweet-
I hope to promote a collaborative environment that continues to support discoveries that impact health and a positive place to work that values mentoring, diversity, and scientific integrity. Join us! Recruiting at all levels. https://t.co/zzxDkcnvZR
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Mashup Score: 2Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis - 2 year(s) ago
Normal adipogenesis requires de novo DNA methyltransferase 3A (DNMT3A) for proper differentiation and suppression of an age-associated pathogenic inflammatory program.
Source: eLifeCategories: Hem/Oncs, Latest HeadlinesTweet-
A new role for #DNMT3A in weight regulation via adipose progenitors, now out @eLife! Mice with heterozygous loss of DNMT3A become obese due in part to adipose-progenitor defects. https://t.co/17KLheBiOZ
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Mashup Score: 0The disordered N-terminal domain of DNMT3A recognizes H2AK119ub and is required for postnatal development - 2 year(s) ago
DNA methyltransferase 3a (DNMT3A) plays a crucial role during mammalian development. Two isoforms of DNMT3A are differentially expressed from stem cells to somatic tissues, but their individual functions remain largely uncharacterized. Here we report that the long isoform DNMT3A1, but not the short DNMT3A2, is essential for mouse postnatal development. DNMT3A1 binds to and regulates bivalent…
Source: www.nature.comCategories: Hem/Oncs, Latest HeadlinesTweet-
Excited to share our latest study on #DNMT3A identifying a new chromatin reader domain in the N-terminus that is essential for post-natal life. https://t.co/yVKFVaiw5G
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Mashup Score: 0
A new study demonstrates that the disordered N-terminal domain of DNMT3A1 binds PRC1-catalyzed H2AK119ub, targeting DNA methylation to bivalent promoters in mouse brain cortical cells. Methylation around bivalent genes is critical for mouse postnatal development, and could be equally important in other cell types and in disease.
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet-
Thus, the DNMT3A1 N-term contains a Polycomb mark “reader” bringing 3A1 to bivalent domains, a relationship required for learning, memory and life. Thanks to @aledjohnparry and Wolf Reik @ReikLab for the excellent News&Views! https://t.co/bunnjVJYnd
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Mashup Score: 11Two competing mechanisms of DNMT3A recruitment regulate the dynamics of de novo DNA methylation at PRC1-targeted CpG islands - Nature Genetics - 2 year(s) ago
DNMT3A PWWP domain mutations promote localization of DNMT3A to CpG islands in a PRC1-dependent manner. DNMT3A interacts with H2AK119ub-modified nucleosomes.
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet-
The role of the #DNMT3A1 N-terminus in targeting PRC1-marked CpG islands is also supported by recent work from David Allis’s lab @RockefellerUniv, J Majewski, @LuLaboratory et al. https://t.co/pWuKSFSKnx
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Mashup Score: 25Please wait whilst we redirect you - 2 year(s) ago
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Source: www.sciencedirect.comCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @NakadaLab: https://t.co/ESkpQrnI4Q Product of a fun collaboration with @chasz43 and his team. SEPHS2, a regulator of selenoprotein syn…
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Mashup Score: 3Director of Human Stem Cell Core, Assistant Professor - 3 year(s) ago
Director of Human Stem Cell Core, Assistant Professor
Source: jobs.bcm.eduCategories: Hem/Oncs, Latest HeadlinesTweet-
We are hiring a new Director of the Human Stem Cell Core @bcmhouston. Great opportunity to run a well-supported Core in an excellent environment and become a faculty member of the Molecular and Cellular Biology Dept. https://t.co/od2P8BaWTX Join us! Please RT! https://t.co/nKYQj5MA3w
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Embryonic-derived mosaicism is likely highly under-appreciated and yet can have significant implications for the identification, management, and transmission of a variety of conditions. Eg #TBRS #DNMT3A @TBRSCommunity https://t.co/KcLRUEheA9