• Mashup Score: 0

    Objective To evaluate the safety and efficacy of tocilizumab (TCZ) in giant cell arteritis (GCA) in a large North American cohort. Methods Patients with GCA treated with TCZ between January 1, 2010, and May 15, 2020, were retrospectively identified. Kaplan-Meier methods were used to estimate time to TCZ discontinuation and time to first relapse after TCZ discontinuation. Poisson regression models were used to compare annualized relapse rates before, during, and after TCZ use. Age- and sex-adjusted risk factors associated with relapse on and off TCZ and development of adverse events of significant interest (AESIs) were examined using Cox models. Results One hundred fourteen patients (60.5% female) were included with mean (SD) age 70.4 (8.2) years. Median duration from GCA diagnosis to TCZ start was 4.5 months. Median overall duration of TCZ treatment was 2.3 years. Relapse rate prior to TCZ start (0.84 relapses/person-year) was 3-fold reduced while on TCZ (0.28 relapses/person-year; P <

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  • Mashup Score: 7

    Bywaters lesion is a cutaneous vasculitis seen in rheumatoid arthritis.1 A 70-year-old man presenting with polyarthritis and finger papules visited our hospital. The patient had a 12-year history of polyarthritis, and bilateral ulnar deviation developed 5 years prior. Computed tomography indicated interstitial pneumonia, and blood work confirmed a rheumatoid factor level of 2708 (normal < 15) IU/mL and anticyclic citrullinated peptide antibody …

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    • Images in Rheumatology Bywaters Lesions: A Rare Cutaneous Vasculitis in Rheumatoid Arthritis 📰 https://t.co/uJfrBg2lce #bywaterslesions #cutaneousvasculitis #rheumatoidvasculitis #vasculitis https://t.co/OF5d4S905c