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Mashup Score: 0Symptom Severity and Glucocorticoid Dosing in Patients With Polymyalgia Rheumatica and Obesity - 7 hour(s) ago
Objective Polymyalgia rheumatica (PMR) is an inflammatory disorder of the elderly characterized by girdle pain and stiffness. Obesity has an influence on disease activity and outcome in rheumatic diseases like osteoarthritis and rheumatoid arthritis. We aimed to investigate the relationship between high BMI and the severity and outcome of PMR, which is incompletely understood. Methods In a post hoc analysis, 83 patients with recent-onset PMR were studied over 6 months using clinical examination, laboratory evaluation, and girdle ultrasound (US). The modified Health Assessment Questionnaire (mHAQ), 36-item Short Form Health Survey (SF-36), and PMR visual analog scale (VAS) scores, as well as prednisone therapy data, were recorded. Patients were grouped according to their BMI. Results At baseline, the 12 patients with obesity had significantly more shoulder pain ( P = 0.03), global pain ( P = 0.03), PMR VAS ( P < 0.01), and fatigue ( P = 0.03); higher mHAQ ( P = 0.01); and lower SF-36 ph
Source: www.jrheum.orgCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 15The Lived Experiences of Older Adults With Systemic Lupus Erythematosus: Patient Perspectives - 1 day(s) ago
Objective Little is known about perceptions of aging among individuals with systemic lupus erythematosus (SLE). Gaining this knowledge could help to identify targets for future behavioral interventions aimed at successful aging with SLE. This qualitative study sought to elicit the lived experiences and essence of aging from older adults with SLE. Methods We conducted semistructured interviews with adults aged ≥ 65 years with SLE seen at a single tertiary center. Qualitative data were analyzed thematically using a phenomenological approach. We collected data on sociodemographic characteristics and disease features prior to each qualitative interview. Results Among 30 participants with a mean age of 71.3 years and mean SLE duration of 26.3 years (range 5-62 yrs), 4 overarching themes emerged to describe the essence of aging with SLE: SLE and comorbid conditions, cumulative effect of SLE symptoms, SLE disease trajectory, and self-perceptions of aging. Older adults with SLE shared variable
Source: www.jrheum.orgCategories: General Medicine News, RheumatologyTweet-
Research Article The Lived Experiences of Older Adults With Systemic Lupus Erythematosus: Patient Perspectives 📖 https://t.co/g3qfvAD5hI @HSpecialSurgery #aging #lupus https://t.co/QcADUYfOF1
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Mashup Score: 2Patient Profiles in Randomized Controlled Trials Versus a Real-World Study in Psoriatic Arthritis: Scoping Review and Metaanalysis - 1 day(s) ago
Objective Patients with psoriatic arthritis (PsA) in randomized controlled trials (RCTs) may not reflect patients with PsA in clinical practice. Our objective was to perform a metaanalysis comparing the characteristics of patients with PsA in RCTs of biologic disease-modifying antirheumatic drugs (bDMARDs) to patient profiles in a real-world study. Methods Data sources included (1) a scoping literature review of phase III RCTs of bDMARDs in PsA published between 2015 and 2020, and (2) an international observational study of patients with PsA starting a bDMARD enrolled between 2015 and 2018 (PsABio; [ClinicalTrials.gov][1]: [NCT02627768][2]). Data collected at baseline included swollen and tender joint counts (SJC/TJC), presence of enthesitis, skin involvement (body surface area [BSA]), C-reactive protein (CRP), physician global assessment (PGA), and patient-reported outcomes (PROs; Health Assessment Questionnaire [HAQ], pain). Univariate random effects metaanalysis was conducted to cal
Source: www.jrheum.orgCategories: General Medicine News, RheumatologyTweet-
Research Article Patient Profiles in Randomized Controlled Trials Versus a Real-World Study in Psoriatic Arthritis: Scoping Review and Metaanalysis 📖 https://t.co/bJoXzUxERf @AlleGelsomina @StefanSiebert1 @LavieFrederic #psoriaticarthritis #registries https://t.co/KezdHs4kdR
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Mashup Score: 5
Objective To investigate the course of disability related to the upper extremities (UEs) in early rheumatoid arthritis (RA), and to assess correlations between such disability and clinical variables, including grip force. Methods In an inception cohort of patients with early RA (diagnosed 1995-2005, N = 222, follow-up 10 yrs), disability of the UEs was assessed using a subscore of the Health Assessment Questionnaire–Disability Index (HAQ-DI-UE), and average grip force of the dominant hand was measured. Changes between consecutive follow-up visits in the HAQ-DI-UE subscore, and correlations at each visit with key clinical variables, were assessed. The relation between joint involvement and HAQ-DI-UE was examined using multivariate linear regression analysis. Results The HAQ-DI-UE decreased significantly from inclusion to the 6-month follow-up (mean change −0.26, 95% CI −0.18 to −0.34), and increased significantly after 2 years. There were fairly strong correlations for HAQ-DI-UE with gr
Source: www.jrheum.orgCategories: General Medicine News, RheumatologyTweet-
Research Article Disability Related to the Upper Extremities in Early Rheumatoid Arthritis—Long-Term Course and Disease Variable Impact: A Cohort Study 📖 https://t.co/cbb1mofkxy @lunduniversity #rheumatoidarthritis #disability #gripforce https://t.co/1prypXxEhW
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Mashup Score: 10The Early Course of Radiographic Progression in Axial Spondyloarthritis: Have We Missed Something? - 3 day(s) ago
The DESIR ( Devenir des spondylarthropathies indifférenciées récentes ) cohort is a rather successful 10-year follow-up study of 708 patients with early inflammatory back pain lasting > 3 months and < 3 years, and recruited within 26 months in 25 centers in France. Patients were followed up every 6 months during the first 2 years and then once every year.1 The mean age at baseline was 34 (SD 9) years, 54% were female, and 57% were HLA-B27 positive. Very recently, the 10-year data on radiographic progression of patients from this cohort, classified as having either nonradiographic axial spondyloarthritis (nr-axSpA) or radiographic axSpA (r-axSpA; also known as ankylosing spondylitis [AS]), were published.2 In axSpA, the axial skeleton is mainly affected through inflammation and new bone formation; this is well known to mostly start in the third decade of life, with patients often presenting with the characteristic feature of inflammatory back pain. The difference between the classificat
Source: www.jrheum.orgCategories: General Medicine News, RheumatologyTweet-
Editorial The Early Course of Radiographic Progression in Axial Spondyloarthritis: Have We Missed Something? 📖 https://t.co/kLiSUvk8T2 #radiographic #progression #axSpA https://t.co/Z23KQbLDcQ
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Mashup Score: 0Pursuing Gender Equity in Rheumatology: Thinking Beyond Gender Representation to Assess Gender Equality - 3 day(s) ago
Over the past 50 years, the representation of women in the rheumatology workforce has increased significantly. Despite this demographic shift, gender inequity and underrepresentation of women in senior rheumatology positions persist. In this article, we consider the state of gender equity in rheumatology, highlighting both the advances and the ongoing challenges. We explore the systemic factors and implicit biases that continue to perpetuate inequity while assessing strategies from the broader medical literature aimed at promoting equality of outcomes for all medical professionals, regardless of gender. Achieving true gender equity in rheumatology necessitates a concerted effort to address implicit biases and foster an inclusive environment that promotes equal opportunities for all. Female representation in medicine has improved, propelled by antidiscrimination legislation and the implementation of institutional policies aimed at addressing gender inequity.1-4 Rheumatology exemplifies
Source: www.jrheum.orgCategories: General Medicine News, RheumatologyTweet-
Editorial Pursuing Gender Equity in Rheumatology: Thinking Beyond Gender Representation to Assess Gender Equality 📖 https://t.co/hUiLFHJnda @StVincentsMelb @TheRMH #gender #rheumatology #workforce https://t.co/FPSx1kktaj
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Mashup Score: 2
Objective To analyze changes in baseline characteristics of patients with very early rheumatoid arthritis (RA) over 24 years in the Early Undifferentiated Polyarthritis (EUPA) cohort. Methods Consecutive patients with recent-onset polyarthritis fulfilling RA classification criteria recruited in EUPA were assessed at baseline. Three successive periods were defined: (1) prior to the general availability of biologics (1998-2004; 245 patients), (2) prior to the implantation of the 2010 classification criteria (2005-2010; 266 patients), and (3) the most recent decade (2011-2022; 329 patients). Results At baseline, demographics, BMI, swollen and tender joint counts, proportion fulfilling 2010 American College of Rheumatology/European Alliance of Associations for Rheumatology criteria, modified Health Assessment Questionnaire, shared epitope status, patient-reported outcomes except pain, and patient global assessment of disease activity remained stable over the 3 periods. Despite a marked dec
Source: www.jrheum.orgCategories: General Medicine News, RheumatologyTweet-
Research Article Changes at Presentation in Patients With Early Rheumatoid Arthritis: A 24-Year Study of the Early Undifferentiated Polyarthritis (EUPA) Cohort 📖 https://t.co/vpLIuiTiJm @USherbrooke #diseaseactivity #comorbidities #rheumatoidarthritis https://t.co/lX8dZbtb5s
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Mashup Score: 9Rheumatoid Arthritis Treatment Has Changed Dramatically Over the Past 3 Decades, but Has the Disease Itself Changed? - 4 day(s) ago
It is now well established that if an individual exhibiting the clinical and serological features of early rheumatoid arthritis (RA) accesses appropriate and timely rheumatological care, the trajectory and outcome of this disease has dramatically improved over the last number of decades.1 The availability of multiple pharmacological and nonpharmacological interventions, coupled with timely management strategies such as treat-to-target, has resulted in a substantial number of patients diagnosed with RA achieving remission or low disease activity at an early stage of their disease. In turn, this has translated into declines in the accrual of irreversible joint damage and functional loss that were the hallmark of this disease as recently as 3 decades ago. Rheumatologists whose practice has spanned this period of time can uniformly attest to this spectacular progress, although there remains a significant minority of patients with RA with refractory disease who continue to have unfavorable
Source: www.jrheum.orgCategories: General Medicine News, RheumatologyTweet-
Editorial Rheumatoid Arthritis Treatment Has Changed Dramatically Over the Past 3 Decades, but Has the Disease Itself Changed? 📖 https://t.co/kkt93oSKuC @UM_RadyFHS #diseaseactivity #comorbidities #rheumatoidarthritis https://t.co/ti85BcpvYE
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Mashup Score: 1Improved Pain, Morning Stiffness, and Fatigue With Bimekizumab in Axial Spondyloarthritis: Results From the Phase III BE MOBILE Studies - 21 day(s) ago
Objective To assess the effect of bimekizumab on pain, morning stiffness, and fatigue in patients with nonradiographic and radiographic axial spondyloarthritis (axSpA) in the phase III BE MOBILE studies ([ClinicalTrials.gov][1]: [NCT03928704][2] and [NCT03928743][3]). Methods Patients were randomized to bimekizumab 160 mg or placebo every 4 weeks; and all patients received bimekizumab from week 16. Patients reported spinal pain, peripheral pain, morning stiffness, and fatigue to week 52. Total and nocturnal spinal pain were each assessed on a 0-10 numerical rating scale (NRS). Individual Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) items (0-10–point NRS) assessed peripheral arthritis pain (question [Q] 3), enthesitis pain/discomfort (Q4), morning stiffness (mean of Q5 and Q6), and fatigue (Q1). Functional Assessment of Chronic Illness Therapy Fatigue subscale score (FACIT-Fatigue) is also reported. Results At week 16, bimekizumab-treated patients reported lower mean noct
Source: www.jrheum.orgCategories: General Medicine News, RheumatologyTweet-
Visual Abstract Improved Pain, Morning Stiffness, and Fatigue With Bimekizumab in Axial Spondyloarthritis: Results From the Phase III BE MOBILE Studies Read the full article: 📰 https://t.co/hizK9gT9ca @deodhara #axialspondyloarthritis #pain #fatigue #stiffness https://t.co/KsQ6IGUOB5
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Mashup Score: 3
Renal lesions as the initial presentation of IgG4-related disease (IgG4-RD) and isolated IgG4-related kidney disease (IgG4-RKD) are rare.1,2 A 65-year-old male with a history of high-grade urothelial cell carcinoma in remission was found to have multiple renal lesions on surveillance imaging (Figure 1A). Urinalysis noted scant nondysmorphic hematuria without proteinuria. Serum creatinine was 1.05 mg/dL, estimated glomerular filtration rate 78 mL/min/1.73 m2, IgG 2430 mg/dL, and IgG4 1970 …
Source: www.jrheum.orgCategories: General Medicine News, RheumatologyTweet-
Images in Rheumatology Renal-Limited IgG4-Related Disease Presenting as Hypodense Lesions Found During Surveillance Imaging in a Patient With High-Grade Urothelial Cell Carcinoma 📖 https://t.co/ijVDUKzrS4 @MayoClinic #IgG4RD #IgG4RKD #kidneydisease https://t.co/kEBIIUQaKM
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Research Article Symptom Severity and Glucocorticoid Dosing in Patients With Polymyalgia Rheumatica and Obesity 📖 https://t.co/8pa90Gn6rG @CrowsonCindy @profbdasgupta @DCamellino #glucocorticoids #obesity #polymyalgiarheumatica https://t.co/P8Z6aasoth