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Mashup Score: 1The Dermatomyositis Disease Symptom Questionnaire (DM-DSQ): A Measure to Assess the Patient Experience of Dermatomyositis Symptoms - 2 day(s) ago
Objective Dermatomyositis (DM) symptoms negatively affect the quality of life of individuals living with the disease. Disease-specific, patient-reported outcome (PRO) instruments are needed to assess symptoms important to individuals with DM. This study aimed to conceptualize patient DM experience and disease activity definition to refine the development of the Dermatomyositis Disease Symptom Questionnaire (DM-DSQ), a novel PRO instrument capturing patient-reported symptoms. Methods An observational, qualitative study was conducted with 30 individuals with DM (aged ≥ 18 yrs) in the US. A 1-hour semistructured interview, including concept elicitation and cognitive debriefing, was conducted with each participant. Inductive coding was used to identify concepts; a saturation analysis was conducted to confirm sample size. Concepts from transcripts were used to refine the preliminary conceptual model and DM-DSQ items. Results Concept elicitation analysis findings included disease symptoms (e
Source: www.jrheum.orgCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 4Acute Severe Inflammatory Lumbar Spinal Pain Induced by Calcium Pyrophosphate Crystals: Computed Tomography Is Everything - 12 day(s) ago
Acute back pain with neurological symptoms is a medical emergency. Here we report a case of severe degenerative spine disease with raised inflammatory markers due to an atypical cause. A 90-year-old male patient presented to our emergency department with acute sciatica-like back pain, urinary retention, constipation, and weakness in his lower limbs (manual muscle testing grade 4/5). His C-reactive protein was raised at 400 mg/L (normal < 7 mg/L) with neutrophil leukocytosis. His …
Source: www.jrheum.orgCategories: General Medicine News, RheumatologyTweet-
Images in Rheumatology Acute Severe Inflammatory Lumbar Spinal Pain Induced by Calcium Pyrophosphate Crystals: Computed Tomography Is Everything 📖 https://t.co/BrJk35c0NO #spinal #pain #CTscan https://t.co/xyhSha1zBd
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Mashup Score: 54Lincoln Sign in Synovitis, Acne, Pustulosis, Hyperostosis, and Osteomyelitis Syndrome - 13 day(s) ago
Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is characterized by skin lesions and osteomyelitis. Although the pathogenesis of SAPHO syndrome remains unclear, chronic focal infection may play a role in the development of excessive immune responses. The patient, a 21-year-old Asian man, was admitted to our department due to jaw swelling and pain. His symptoms began …
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Images in Rheumatology Lincoln Sign in Synovitis, Acne, Pustulosis, Hyperostosis, and Osteomyelitis Syndrome 📖 https://t.co/k6yiuUCkKV #lincolnsign #saphosyndrome https://t.co/5iUW160mxE
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Mashup Score: 1Unmet Needs in Spondyloarthritis: Pathogenesis, Clinical Trial Design, and Nonpharmacologic Therapy - 15 day(s) ago
A program focused on pathogenesis, clinical trial design, and nonpharmacologic mind-body therapy for spondyloarthritis (SpA) was presented at the Spondylitis Association of America Unmet Needs Conference IV. SpA pathogenesis is incompletely understood but involves a complex set of drivers, including genetics, biomechanical stress, and microbial factors. Affected tissues may include axial and peripheral joints, entheses, skin, uvea, and intestines. The specific role of key cytokines like interleukin (IL)-23, IL-17, and tumor necrosis factor in the phases of this inflammatory process remains unclear. New insights into pathogenesis will continue to generate targets for novel therapeutics. How to optimally evaluate those therapeutics in clinical trials, and for the various manifestations of SpA, remains less clear. Future trials need better generalizability, robust subgroup analyses to assess differential responses for distinct disease manifestations, a focus on comparative efficacy, and o
Source: www.jrheum.orgCategories: General Medicine News, RheumatologyTweet-
Proceedings Unmet Needs in Spondyloarthritis: Pathogenesis, Clinical Trial Design, and Nonpharmacologic Therapy 📖 https://t.co/pWJj5SddwO #ankylosingspondylitis #outcomes #spondyloarthropathy https://t.co/qI6O7yL8hM
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Mashup Score: 0Enhancing Equity in Clinical Research: A Multifaceted Proposal for Spondyloarthritis - 15 day(s) ago
Clinical research advances medical knowledge and improves healthcare outcomes. However, disparities in research participation hinder progress. The Unmet Research Needs in Spondyloarthritis Conference IV highlighted critical insights and strategies to enhance equity in clinical research. Talks focused on engaging underrepresented communities and addressing disparities in rheumatic diseases, particularly spondyloarthritis (SpA), to ensure research results are generalizable and inclusive. Disparities in SpA management, such as greater back pain severity among Black and Hispanic Americans and sex-based differences in pain management, emphasize the need for equitable research. Dr. Elizabeth Ferucci discussed the racial disparities in rheumatologic care, highlighting the importance of early access to rheumatologists and culturally informed primary care to improve outcomes. Dr. Hani El-Gabalawy’s talk on engaging Indigenous communities stressed the importance of community consent and reciproc
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Proceedings Enhancing Equity in Clinical Research: A Multifaceted Proposal for Spondyloarthritis 📖 https://t.co/QZTIbanJuc #outcomes #spondyloarthritis https://t.co/CFl5FLKbCT
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Mashup Score: 2
Imaging biomarkers in axial spondyloarthritis (axSpA) are currently the most specific biomarkers for the diagnosis of this condition. Despite advances in imaging, from plain radiographs—which detect only damage—to magnetic resonance imaging (MRI)—which identifies disease activity and structural change—there are still many challenges that remain. Imaging in sacroiliitis is characterized by active and structural changes. Current classification criteria stress the importance of bone marrow edema (BME); however, BME can occur in various diseases, mechanical conditions, and healthy individuals. Thus, the identification of structural lesions such as erosion, subchondral fat, backfill, and ankylosis is important to distinguish from mimics on differential diagnosis. Various imaging modalities are available to examine structural lesions, but computed tomography (CT) is considered the current reference standard. Nonetheless, recent advances in MRI allow for direct bone imaging and the reconstruc
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Proceedings Unmet Needs in Spondyloarthritis: Imaging in Axial Spondyloarthritis 📖 https://t.co/BH4yuT4kb3 #axialspondyloarthritis #imaging https://t.co/mk7RbhNpi2
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Mashup Score: 5
Among patients with axial spondyloarthritis (axSpA), persistent pain remains a critical unmet need. In this review, we discuss the prevalence of chronic pain and fibromyalgia in patients with axSpA and examine the existing knowledge on the pathophysiology of chronic pain in SpA, osteoarthritis, and rheumatoid arthritis. Finally, we discuss the specific unmet needs that must be addressed to improve long-term outcomes in axSpA, specifically those that will improve chronic pain in this patient population.
Source: www.jrheum.orgCategories: General Medicine News, RheumatologyTweet-
First Release Unmet Needs in Spondyloarthritis: Understanding and Managing Chronic Pain 📖 https://t.co/hyrA3NEGUf Unmet Needs in Spondyloarthritis: Imaging in Axial Spondyloarthritis 📖 https://t.co/BH4yuT3Mlv @spondylitis @NIH_NIAMS
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Mashup Score: 0Are There Disease Endotypes in Axial Spondyloarthritis and How Would We Define Them? - 15 day(s) ago
Is axial spondyloarthritis (axSpA) one disease or does it comprise multiple types? If the latter, how do we define those types—through clinical or imaging features, HLA-B27 status, or by other immunologic features? Data comparing disease outcomes for individuals with nonradiographic vs radiographic axSpA, or for male vs female patients, demonstrate distinctions. So then, how should we define endotypes? Endotypes are known as the subtype of a health condition defined by a functional or pathophysiologic function. Here, we review the endotypes used for defining rheumatoid arthritis, asthma, and psoriatic arthritis. Taking the lessons learned from these diseases, we discuss how they can be applied to defining endotypes in axSpA. A key unmet need for axSpA is access to affected tissues for interrogation of their pathologic mechanisms, from which tissue-specific endotypes can be defined. These tissue-based features should be combined with clinical data and imaging to inform classification cr
Source: www.jrheum.orgCategories: General Medicine News, RheumatologyTweet-
Proceedings Are There Disease Endotypes in Axial Spondyloarthritis and How Would We Define Them? 📖 https://t.co/YbPlgi3OrK #ankylosingspondylitis #endotypes #psoriaticarthritis #rheumatoidarthritis #spondyloarthritis https://t.co/M2i6ERhQid
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Mashup Score: 0Prologue: Spondyloarthritis Unmet Research Needs Conference IV - 15 day(s) ago
The Spondylitis Association of America (SAA) and the National Institute of Arthritis, Musculoskeletal and Skin Diseases (NIAMS) convened a conference on the campus of the National Institutes of Health (NIH) on September 28 and 29, 2023, to identify unmet needs in spondyloarthritis (SpA) research. The conference featured presentations by experts in areas of disease endotypes, pain, innovative imaging in SpA, health disparities in rheumatic diseases, and therapeutics. Members of the conference planning committee moderated the sessions and led the development of manuscripts summarizing recommendations to address unmet research needs. Early career investigators were invited to submit abstracts, which were presented at a networking session during the conference. Here, we highlight each of the sessions comprising the conference in the form of manuscripts published together as a conference summary.
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Proceedings Prologue: Spondyloarthritis Unmet Research Needs Conference IV @spondylitis @NIH_NIAMS 📖 https://t.co/oWOMHNtDBe #spondyloarthritis #SpA #endotypes #healthdisparities #rheumaticdiseases https://t.co/5niHVB0v1M
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Mashup Score: 7
Objective To examine whether gut microbes were associated with postsurgery-sustained knee pain in patients with knee osteoarthritis (OA) by a gut microbiomics approach. Methods Patients receiving total knee replacement (TKR) because of primary knee OA were recruited. Sustained knee pain status at ≥ 1 year after TKR was defined by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Fasting plasma and fecal samples were collected. Metabolomic profiling was performed on fasting plasma. 16S rRNA sequencing was performed on fecal samples to determine microbial composition. Results Twenty patients with TKR because of primary knee OA were included in the study, with 10 experiencing sustained postsurgery pain and 10 without such pain. Age, sex, and BMI (kg/m2) were matched. Linear discriminant analysis of microbiome data identified 13 bacterial taxa that were highly abundant in the pain group and 5 that were highly abundant in the nonpain group ( P < 0.05 for all). Plas
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Research Article Gut Microbiomics of Sustained Knee Pain in Patients With Knee Osteoarthritis 📖 https://t.co/jIPkdCTpmb #microbiome #metabolism #osteoarthritis #pain https://t.co/zvGjfMhKOX
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Research Article The Dermatomyositis Disease Symptom Questionnaire (DM-DSQ): A Measure to Assess the Patient Experience of Dermatomyositis Symptoms 📖 https://t.co/xJn3KK5VLY #dermatomyositis #diseaseactivity #outcomeassessment #qualityoflife https://t.co/qbmSGDt09N